Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Crenolanib C26H29N5O2 443.5 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24 Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 39 0
MKK2 32 2
MKK6 94 6
ERK1 105 10
ERK2 98 7
ERK5 57 1
JNK1 100 7
JNK2 99 4
JNK3 90 14
p38 alpha MAPK 92 6
p38 beta MAPK 118 1
p38 gamma MAPK 104 1
p38 delta MAPK 107 5
ERK8 10 1
RSK1 14 1
RSK2 46 4
PDK1 94 2
PKB alpha 104 12
PKB beta 120 30
SGK1 80 4
S6K1 80 4
PKA 105 8
ROCK 2 36 3
PRK2 5 1
PKC alpha 78 8
PKC gamma 89 5
PKC zeta 115 12
PKD1 66 2
STK33 93 18
MSK1 60 1
MNK1 35 4
MNK2 16 1
MAPKAP-K2 112 4
MAPKAP-K3 120 14
PRAK 98 0
CAMKK beta 3 0
CAMK1 58 0
SmMLCK 102 8
PHK 1 0
DAPK1 95 15
CHK1 77 4
CHK2 107 4
GSK3 beta 95 12
CDK2-Cyclin A 6 1
CDK9-Cyclin T1 12 2
PLK1 104 6
Aurora A 106 5
Aurora B 23 6
TLK1 108 8
LKB1 72 5
AMPK (hum) 2 1
MARK1 14 1
MARK2 31 0
MARK3 8 2
MARK4 24 3
BRSK1 30 0
BRSK2 41 4
MELK 34 6
NUAK1 4 0
SIK2 6 3
SIK3 11 11
TSSK1 46 3
CK1 gamma 2 85 14
CK1 delta 100 10
CK2 100 2
TTBK1 107 4
TTBK2 107 0
DYRK1A 31 1
DYRK2 103 9
DYRK3 47 2
NEK2a 117 4
NEK6 93 5
IKK beta 100 7
IKK epsilon 87 6
TBK1 55 7
PIM1 61 7
PIM2 91 4
PIM3 87 1
SRPK1 102 3
EF2K 109 5
EIF2AK3 112 2
HIPK1 109 0
HIPK2 90 10
HIPK3 101 15
CLK2 49 8
PAK2 96 2
PAK4 61 12
PAK5 81 1
PAK6 101 11
MST2 5 1
MST3 41 2
MST4 91 0
GCK 13 4
MAP4K3 0 0
MAP4K5 6 1
MINK1 17 1
MEKK1 89 2
MLK1 2 1
MLK3 4 1
TESK1 146 16
TAO1 52 2
ASK1 108 3
TAK1 41 9
IRAK1 48 3
IRAK4 28 5
RIPK2 10 0
OSR1 109 11
TTK 75 18
MPSK1 108 22
WNK1 109 7
ULK1 36 8
ULK2 4 1
TGFBR1 133 15
Src 72 7
Lck 21 4
CSK 81 7
YES1 26 3
ABL 45 1
BTK 113 3
JAK2 66 4
SYK 87 13
ZAP70 107 5
TIE2 92 0
BRK 111 19
EPH-A2 86 7
EPH-A4 69 10
EPH-B1 110 5
EPH-B2 96 10
EPH-B3 99 4
EPH-B4 98 9
FGF-R1 77 3
HER4 108 11
IGF-1R 111 8
IR 97 17
IRR 80 6
TrkA 2 0
DDR2 10 3
VEGFR1 5 1
PDGFRA 10 1
PINK 122 8

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