Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Volasertib C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102 Grinshtein N (2011) Cancer Res 71(4) 1385-1395 Selleck Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 80 5
MKK2 72 16
MKK6 89 25
ERK1 91 7
ERK2 104 8
ERK5 87 2
JNK1 101 3
JNK2 93 14
JNK3 91 16
p38 alpha MAPK 95 2
p38 beta MAPK 107 1
p38 gamma MAPK 98 3
p38 delta MAPK 99 5
ERK8 109 2
RSK1 69 7
RSK2 82 13
PDK1 87 4
PKB alpha 95 3
PKB beta 104 3
SGK1 94 9
S6K1 89 11
PKA 97 1
ROCK 2 94 8
PRK2 98 19
PKC alpha 103 7
PKC gamma 96 3
PKC zeta 91 0
PKD1 49 5
STK33 82 6
MSK1 99 6
MNK1 98 7
MNK2 103 4
MAPKAP-K2 95 10
MAPKAP-K3 100 12
PRAK 93 3
CAMKK beta 13 1
CAMK1 91 8
SmMLCK 33 10
PHK 87 9
DAPK1 77 9
CHK1 104 3
CHK2 67 8
GSK3 beta 93 10
CDK2-Cyclin A 92 5
CDK9-Cyclin T1 78 14
PLK1 2 1
Aurora A 85 7
Aurora B 85 11
TLK1 95 24
LKB1 99 4
AMPK (hum) 97 13
MARK1 87 23
MARK2 91 18
MARK3 105 10
MARK4 96 3
BRSK1 82 0
BRSK2 71 6
MELK 68 22
NUAK1 92 17
SIK2 89 14
SIK3 97 4
TSSK1 88 1
CK1 gamma 2 88 13
CK1 delta 108 12
CK2 106 15
TTBK1 102 6
TTBK2 102 8
DYRK1A 95 11
DYRK2 72 8
DYRK3 87 6
NEK2a 67 8
NEK6 111 25
IKK beta 93 4
IKK epsilon 92 20
TBK1 97 4
PIM1 94 9
PIM2 97 10
PIM3 80 18
SRPK1 101 3
EF2K 97 4
EIF2AK3 58 4
HIPK1 102 8
HIPK2 98 10
HIPK3 95 3
CLK2 36 6
PAK2 91 25
PAK4 94 12
PAK5 105 10
PAK6 105 10
MST2 88 7
MST3 101 8
MST4 89 10
GCK 71 2
MAP4K3 68 1
MAP4K5 85 23
MINK1 79 1
MEKK1 95 18
MLK1 83 1
MLK3 99 24
TESK1 93 8
TAO1 98 1
ASK1 93 3
TAK1 94 4
IRAK1 79 14
IRAK4 92 5
RIPK2 100 11
OSR1 59 1
TTK 82 6
MPSK1 72 20
WNK1 101 5
ULK1 92 4
ULK2 103 11
TGFBR1 112 31
Src 90 14
Lck 96 8
CSK 87 2
YES1 93 5
ABL 83 12
BTK 106 2
JAK2 83 18
SYK 89 2
ZAP70 85 12
TIE2 82 0
BRK 90 17
EPH-A2 97 5
EPH-A4 90 0
EPH-B1 91 7
EPH-B2 122 0
EPH-B3 103 5
EPH-B4 97 1
FGF-R1 93 3
HER4 87 12
IGF-1R 87 30
IR 93 8
IRR 89 6
TrkA 75 3
DDR2 104 23
VEGFR1 96 16
PDGFRA 108 10
PINK 93 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 6
MKK2 92 20
MKK6 79 16
ERK1 104 11
ERK2 98 13
ERK5 88 1
JNK1 106 5
JNK2 99 20
JNK3 91 6
p38 alpha MAPK 96 17
p38 beta MAPK 116 4
p38 gamma MAPK 91 4
p38 delta MAPK 97 17
ERK8 110 2
RSK1 89 9
RSK2 95 18
PDK1 87 4
PKB alpha 108 9
PKB beta 96 14
SGK1 91 7
S6K1 88 0
PKA 104 9
ROCK 2 82 10
PRK2 114 15
PKC alpha 105 11
PKC gamma 107 8
PKC zeta 95 18
PKD1 78 7
STK33 87 0
MSK1 88 1
MNK1 92 8
MNK2 107 2
MAPKAP-K2 90 6
MAPKAP-K3 94 4
PRAK 90 8
CAMKK beta 61 4
CAMK1 90 11
SmMLCK 75 22
PHK 107 11
DAPK1 96 4
CHK1 93 9
CHK2 103 1
GSK3 beta 98 12
CDK2-Cyclin A 90 7
CDK9-Cyclin T1 82 4
PLK1 4 1
Aurora A 88 7
Aurora B 89 5
TLK1 91 1
LKB1 89 4
AMPK (hum) 101 2
MARK1 87 1
MARK2 94 3
MARK3 102 8
MARK4 103 11
BRSK1 93 3
BRSK2 78 2
MELK 93 6
NUAK1 95 8
SIK2 84 2
SIK3 106 13
TSSK1 106 13
CK1 gamma 2 108 2
CK1 delta 107 10
CK2 107 6
TTBK1 99 0
TTBK2 114 17
DYRK1A 87 3
DYRK2 85 17
DYRK3 100 15
NEK2a 85 10
NEK6 120 6
IKK beta 89 3
IKK epsilon 87 5
TBK1 105 19
PIM1 90 1
PIM2 100 8
PIM3 99 12
SRPK1 113 5
EF2K 101 9
EIF2AK3 85 1
HIPK1 99 8
HIPK2 112 12
HIPK3 97 5
CLK2 82 19
PAK2 89 3
PAK4 83 11
PAK5 106 3
PAK6 93 2
MST2 82 15
MST3 88 1
MST4 96 17
GCK 87 16
MAP4K3 81 8
MAP4K5 84 6
MINK1 93 17
MEKK1 106 9
MLK1 79 4
MLK3 96 7
TESK1 100 29
TAO1 88 13
ASK1 93 16
TAK1 96 12
IRAK1 90 1
IRAK4 80 10
RIPK2 99 19
OSR1 91 3
TTK 93 4
MPSK1 89 36
WNK1 89 2
ULK1 89 9
ULK2 121 21
TGFBR1 97 2
Src 89 9
Lck 115 16
CSK 83 6
YES1 105 9
ABL 97 4
BTK 101 5
JAK2 105 10
SYK 112 7
ZAP70 88 3
TIE2 81 9
BRK 103 7
EPH-A2 116 1
EPH-A4 99 5
EPH-B1 93 4
EPH-B2 128 19
EPH-B3 123 14
EPH-B4 92 4
FGF-R1 92 3
HER4 93 1
IGF-1R 104 19
IR 116 21
IRR 105 0
TrkA 83 16
DDR2 109 27
VEGFR1 98 13
PDGFRA 115 12
PINK 96 12

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