Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
RO-3306 C₁₈H₁₃N₃OS₂ 351.5 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660 Calbiochem Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 17 4
MKK2 37 4
MKK6 81 2
ERK1 27 0
ERK2 44 4
ERK5 24 1
JNK1 99 8
JNK2 78 8
JNK3 96 11
p38 alpha MAPK 95 11
p38 beta MAPK 96 9
p38 gamma MAPK 11 2
p38 delta MAPK 25 1
ERK8 2 1
RSK1 15 1
RSK2 37 6
PDK1 98 19
PKB alpha 71 1
PKB beta 57 4
SGK1 14 1
S6K1 16 0
PKA 48 4
ROCK 2 10 0
PRK2 3 1
PKC alpha 88 6
PKC gamma 22 1
PKC zeta 99 16
PKD1 15 0
STK33 34 2
MSK1 24 2
MNK1 43 18
MNK2 14 7
MAPKAP-K2 40 5
MAPKAP-K3 77 2
PRAK 76 22
CAMKK beta 7 0
CAMK1 73 5
SmMLCK 14 0
PHK 22 1
DAPK1 26 1
CHK1 13 1
CHK2 8 0
GSK3 beta 27 4
CDK2-Cyclin A 5 0
CDK9-Cyclin T1 42 1
PLK1 107 4
Aurora A 127 20
Aurora B 13 4
TLK1 120 14
LKB1 58 4
AMPK (hum) 10 1
MARK1 48 3
MARK2 83 6
MARK3 35 4
MARK4 73 4
BRSK1 23 1
BRSK2 21 2
MELK 12 2
NUAK1 12 0
SIK2 54 4
SIK3 55 0
TSSK1 9 0
CK1 gamma 2 49 4
CK1 delta 86 3
CK2 20 3
TTBK1 92 2
TTBK2 102 12
DYRK1A 1 0
DYRK2 4 0
DYRK3 4 0
NEK2a 10 2
NEK6 108 11
IKK beta 71 2
IKK epsilon 16 0
TBK1 20 2
PIM1 2 0
PIM2 45 3
PIM3 14 3
SRPK1 79 7
EF2K 89 4
EIF2AK3 102 16
HIPK1 18 3
HIPK2 13 0
HIPK3 18 2
CLK2 1 0
PAK2 82 7
PAK4 35 7
PAK5 62 0
PAK6 61 2
MST2 48 13
MST3 67 4
MST4 22 2
GCK 3 1
MAP4K3 11 1
MAP4K5 35 5
MINK1 4 0
MEKK1 103 2
MLK1 55 2
MLK3 30 5
TESK1 82 4
TAO1 13 2
ASK1 26 0
TAK1 53 1
IRAK1 5 1
IRAK4 41 0
RIPK2 5 1
OSR1 104 1
TTK 51 11
MPSK1 119 17
WNK1 109 15
ULK1 47 4
ULK2 38 0
TGFBR1 115 3
Src 77 5
Lck 63 2
CSK 81 1
YES1 46 2
ABL 70 9
BTK 78 6
JAK2 41 2
SYK 116 11
ZAP70 104 1
TIE2 62 0
BRK 115 6
EPH-A2 98 6
EPH-A4 107 9
EPH-B1 75 8
EPH-B2 93 14
EPH-B3 99 6
EPH-B4 108 12
FGF-R1 88 1
HER4 81 13
IGF-1R 46 8
IR 90 4
IRR 71 6
TrkA 60 6
DDR2 100 3
VEGFR1 22 4
PDGFRA 96 10
PINK 112 9
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 52 1
MKK2 78 20
MKK6 88 7
ERK1 68 1
ERK2 80 16
ERK5 40 1
JNK1 89 8
JNK2 89 12
JNK3 95 13
p38 alpha MAPK 93 4
p38 beta MAPK 101 11
p38 gamma MAPK 26 2
p38 delta MAPK 68 12
ERK8 8 0
RSK1 49 1
RSK2 61 2
PDK1 102 34
PKB alpha 86 5
PKB beta 78 6
SGK1 51 0
S6K1 43 11
PKA 89 0
ROCK 2 34 1
PRK2 8 0
PKC alpha 111 1
PKC gamma 69 1
PKC zeta 114 4
PKD1 38 4
STK33 72 15
MSK1 65 6
MNK1 63 0
MNK2 27 4
MAPKAP-K2 86 11
MAPKAP-K3 90 14
PRAK 110 24
CAMKK beta 21 1
CAMK1 96 10
SmMLCK 43 8
PHK 50 2
DAPK1 62 4
CHK1 37 1
CHK2 36 2
GSK3 beta 64 6
CDK2-Cyclin A 21 0
CDK9-Cyclin T1 82 5
PLK1 95 8
Aurora A 117 5
Aurora B 49 5
TLK1 113 8
LKB1 90 6
AMPK (hum) 40 1
MARK1 81 3
MARK2 97 11
MARK3 75 2
MARK4 81 3
BRSK1 59 9
BRSK2 60 6
MELK 52 1
NUAK1 44 1
SIK2 92 4
SIK3 83 4
TSSK1 41 3
CK1 gamma 2 88 8
CK1 delta 81 15
CK2 66 7
TTBK1 88 8
TTBK2 103 0
DYRK1A 2 0
DYRK2 20 3
DYRK3 14 1
NEK2a 49 2
NEK6 101 24
IKK beta 80 9
IKK epsilon 64 6
TBK1 60 8
PIM1 12 1
PIM2 92 1
PIM3 50 7
SRPK1 89 8
EF2K 93 2
EIF2AK3 98 7
HIPK1 62 9
HIPK2 43 2
HIPK3 52 5
CLK2 6 0
PAK2 100 9
PAK4 79 5
PAK5 98 4
PAK6 102 9
MST2 85 6
MST3 80 2
MST4 54 8
GCK 8 1
MAP4K3 53 3
MAP4K5 69 2
MINK1 12 1
MEKK1 96 8
MLK1 88 4
MLK3 63 7
TESK1 72 16
TAO1 51 6
ASK1 66 2
TAK1 83 2
IRAK1 25 2
IRAK4 83 8
RIPK2 12 1
OSR1 103 1
TTK 65 2
MPSK1 99 9
WNK1 105 3
ULK1 89 5
ULK2 77 10
TGFBR1 96 9
Src 90 9
Lck 93 3
CSK 93 16
YES1 82 0
ABL 100 15
BTK 103 8
JAK2 97 5
SYK 106 7
ZAP70 96 5
TIE2 78 6
BRK 112 3
EPH-A2 105 5
EPH-A4 115 1
EPH-B1 81 21
EPH-B2 99 4
EPH-B3 101 2
EPH-B4 95 11
FGF-R1 93 3
HER4 81 17
IGF-1R 49 1
IR 97 7
IRR 86 9
TrkA 96 15
DDR2 92 27
VEGFR1 59 1
PDGFRA 103 9
PINK 107 6

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