Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
VPS34-IN1 C21H24ClN7O 425.91 Vps34 Bago R (2014) Biochem J. WO2012085815 Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 122 15
MKK2 111 16
MKK6 124 21
ERK1 108 2
ERK2 116 4
ERK5 104 12
JNK1 112 6
JNK2 113 8
JNK3 95 1
p38 alpha MAPK 125 1
p38 beta MAPK 115 0
p38 gamma MAPK 133 8
p38 delta MAPK 111 18
ERK8 36 3
RSK1 99 4
RSK2 103 10
PDK1 105 16
PKB alpha 116 8
PKB beta 123 4
SGK1 108 5
S6K1 116 1
PKA 112 12
ROCK 2 111 2
PRK2 116 6
PKC alpha 119 12
PKC gamma 111 4
PKC zeta 103 0
PKD1 115 6
STK33 124 1
MSK1 105 1
MNK1 122 10
MNK2 100 7
MAPKAP-K2 110 6
MAPKAP-K3 115 18
PRAK 105 8
CAMKK beta 108 2
CAMK1 116 11
SmMLCK 97 6
PHK 105 8
DAPK1 96 7
CHK1 118 26
CHK2 103 4
GSK3 beta 51 1
CDK2-Cyclin A 88 7
CDK9-Cyclin T1 91 19
PLK1 114 5
Aurora A 110 6
Aurora B 83 11
TLK1 100 7
LKB1 106 11
AMPK (hum) 96 18
MARK1 114 12
MARK2 108 9
MARK3 109 4
MARK4 115 7
BRSK1 109 13
BRSK2 98 14
MELK 108 4
NUAK1 112 0
SIK2 106 8
SIK3 112 6
TSSK1 118 15
CK1 gamma 2 122 7
CK1 delta 105 2
CK2 111 0
TTBK1 106 4
TTBK2 88 4
DYRK1A 105 11
DYRK2 109 9
DYRK3 112 18
NEK2a 103 12
NEK6 98 8
IKK beta 106 1
IKK epsilon 103 13
TBK1 125 18
PIM1 108 5
PIM2 113 4
PIM3 114 3
SRPK1 111 1
EF2K 115 12
EIF2AK3 125 17
HIPK1 108 5
HIPK2 96 11
HIPK3 117 20
CLK2 82 3
PAK2 111 9
PAK4 103 2
PAK5 96 6
PAK6 97 7
MST2 120 5
MST3 118 2
MST4 108 5
GCK 104 2
MAP4K3 117 6
MAP4K5 105 2
MINK1 103 1
MEKK1 109 14
MLK1 119 8
MLK3 129 0
TESK1 95 9
TAO1 80 1
ASK1 124 5
TAK1 40 1
IRAK1 112 6
IRAK4 133 0
RIPK2 79 2
OSR1 114 12
TTK 108 0
MPSK1 118 3
WNK1 116 2
ULK1 98 8
ULK2 118 13
TGFBR1 123 9
Src 84 9
Lck 92 5
CSK 132 6
YES1 77 4
ABL 87 6
BTK 108 3
JAK2 93 6
SYK 91 4
ZAP70 110 7
TIE2 93 13
BRK 103 5
EPH-A2 101 2
EPH-A4 93 14
EPH-B1 99 8
EPH-B2 109 2
EPH-B3 111 5
EPH-B4 106 2
FGF-R1 95 8
HER4 101 6
IGF-1R 101 24
IR 109 9
IRR 113 2
TrkA 70 17
DDR2 111 13
VEGFR1 113 5
PDGFRA 121 13
PINK 109 10

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