Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Bosutinib C26H29Cl2N5O3 530.45 src Vultur A. Mol Cancer Ther. (2008) 1185-94 WO2013024144 Cayman Chemical Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
MAP4K5 0 2
EPH-B2 1 1
Src 1 0
Lck 1 0
ABL 1 0
BTK 1 0
YES1 2 1
MAP4K3 3 0
EPH-A4 3 1
EPH-A2 4 0
MINK1 5 1
SIK2 8 0
HER4 9 0
SIK3 9 0
GCK 9 2
EPH-B4 10 0
EPH-B1 12 0
EPH-B3 16 0
MST4 20 1
DDR2 22 1
TrkA 25 2
STK33 34 0
CHK2 37 0
TAK1 41 9
MLK3 42 4
IKK epsilon 46 7
MLK1 52 9
PHK 55 0
IRAK4 55 3
MKK2 60 3
TLK1 63 13
NUAK1 63 12
AMPK (hum) 65 4
CSK 65 7
MST2 65 6
TSSK1 67 1
MST3 68 0
HIPK2 71 7
DYRK2 71 4
IRR 72 5
JAK2 72 5
ERK5 74 6
MARK3 74 10
TIE2 74 3
CLK2 75 9
TBK1 75 1
NEK2a 76 4
CK2 77 3
IRAK1 77 3
SYK 77 2
ULK2 78 10
CAMK1 78 11
ULK1 79 5
EF2K 81 2
MKK1 81 2
CAMKK beta 81 2
TESK1 82 15
LKB1 84 13
MARK1 84 5
TAO1 85 8
DYRK3 85 11
RSK2 86 6
CK1 delta 86 20
PRK2 86 6
RIPK2 86 2
MNK2 87 6
MAPKAP-K2 87 5
TGFBR1 87 14
TTBK2 87 6
IR 87 7
SmMLCK 88 2
JNK1 88 15
PKC gamma 88 6
VEGFR1 88 5
p38 gamma MAPK 88 3
BRK 88 11
SRPK1 89 6
MARK2 89 8
IGF-1R 89 8
PKD1 89 2
RSK1 90 8
DYRK1A 91 3
CHK1 91 2
PKC zeta 91 2
PIM1 91 7
PIM3 92 16
PDK1 92 16
MKK6 92 6
DAPK1 92 3
IKK beta 92 15
MSK1 93 2
Aurora B 93 13
FGF-R1 94 4
p38 beta MAPK 94 15
TTK 94 0
Aurora A 95 2
MEKK1 95 5
TTBK1 95 2
HIPK1 95 0
MELK 95 10
ERK8 96 13
ASK1 96 9
PKC alpha 96 5
OSR1 96 3
PDGFRA 96 1
PLK1 97 12
PRAK 97 2
p38 alpha MAPK 97 4
ERK1 98 5
SGK1 98 20
S6K1 98 1
MNK1 99 14
ROCK 2 99 6
ZAP70 99 4
PIM2 99 0
MARK4 101 7
BRSK1 101 1
CDK9-Cyclin T1 101 8
WNK1 102 2
PKB beta 102 6
HIPK3 102 14
NEK6 102 1
JNK3 102 3
PAK6 103 11
ERK2 104 18
PAK5 105 18
EIF2AK3 107 5
BRSK2 107 12
JNK2 108 20
GSK3 beta 109 6
PKB alpha 110 16
PAK4 110 16
CDK2-Cyclin A 110 32
PKA 111 16
p38 delta MAPK 111 12
PINK 112 9
MAPKAP-K3 113 1
PAK2 115 6
CK1 gamma 2 117 1
MPSK1 117 15
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
EPH-B1 0 2
EPH-B2 0 0
ABL 0 0
EPH-A2 1 0
MAP4K3 1 0
EPH-A4 1 0
MAP4K5 1 0
MINK1 1 0
EPH-B3 1 0
Src 1 0
Lck 1 0
HER4 1 1
YES1 1 0
BTK 1 0
SIK3 2 0
EPH-B4 2 0
DDR2 2 0
SIK2 3 0
GCK 4 0
CSK 4 0
TAK1 5 0
IKK epsilon 6 0
MST4 7 0
TrkA 7 0
MLK3 8 1
CHK2 10 2
PHK 12 0
MST2 17 2
STK33 17 4
MLK1 18 4
NUAK1 21 2
MST3 21 4
MKK2 21 4
TSSK1 22 2
CLK2 23 0
IRAK4 23 0
AMPK (hum) 26 2
JAK2 26 0
CAMKK beta 27 0
SmMLCK 27 1
TBK1 29 1
MKK1 31 9
TLK1 35 3
ULK2 37 1
SYK 39 1
MARK3 41 3
HIPK2 42 4
ULK1 44 2
RIPK2 45 1
BRK 48 0
Aurora B 50 7
VEGFR1 54 3
PRK2 56 3
HIPK1 57 0
CHK1 57 0
IRR 59 1
CK1 delta 60 7
TESK1 61 2
NEK2a 63 2
TIE2 64 3
RSK2 64 1
OSR1 65 2
IRAK1 65 0
MELK 66 1
HIPK3 66 5
ERK5 67 10
MARK2 68 1
RSK1 70 3
p38 alpha MAPK 72 3
MARK4 72 5
PLK1 74 6
FGF-R1 74 6
CAMK1 74 16
ROCK 2 74 7
MARK1 76 4
PDGFRA 79 0
IGF-1R 79 4
MEKK1 85 6
PKD1 86 8
S6K1 86 2
IKK beta 86 8
ERK8 87 3
DYRK2 87 5
PKB beta 90 3
DYRK3 90 16
TTBK2 92 6
PIM1 94 0
MAPKAP-K2 94 5
EF2K 95 6
PIM2 96 8
DYRK1A 96 13
Aurora A 98 6
PDK1 98 0
TTK 99 7
MNK2 100 9
SGK1 100 2
PIM3 101 3
TGFBR1 101 6
PKC gamma 102 5
PKC zeta 102 4
MSK1 102 12
TAO1 102 7
JNK1 102 1
CDK2-Cyclin A 103 5
EIF2AK3 103 0
MAPKAP-K3 103 8
ERK1 103 1
ERK2 103 15
PKC alpha 103 3
WNK1 104 9
LKB1 104 15
MNK1 105 2
PKA 105 7
DAPK1 105 4
CK2 106 1
ASK1 106 1
JNK3 106 10
IR 107 34
p38 beta MAPK 108 24
CK1 gamma 2 108 4
PAK2 108 1
JNK2 108 11
ZAP70 109 18
p38 gamma MAPK 109 5
SRPK1 109 5
MPSK1 110 11
NEK6 111 3
BRSK1 112 5
GSK3 beta 114 22
TTBK1 114 3
MKK6 115 5
p38 delta MAPK 116 12
PKB alpha 116 30
BRSK2 120 4
PINK 125 13
CDK9-Cyclin T1 125 16
PRAK 125 1
PAK4 126 1
PAK5 129 5
PAK6 132 7

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