Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Bosutinib C26H29Cl2N5O3 530.45 src Vultur A. Mol Cancer Ther. (2008) 1185-94 WO2013024144 Cayman Chemical Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 2
MKK2 60 3
MKK6 92 6
ERK1 98 5
ERK2 104 18
ERK5 74 6
JNK1 88 15
JNK2 108 20
JNK3 102 3
p38 alpha MAPK 97 4
p38 beta MAPK 94 15
p38 gamma MAPK 88 3
p38 delta MAPK 111 12
ERK8 96 13
RSK1 90 8
RSK2 86 6
PDK1 92 16
PKB alpha 110 16
PKB beta 102 6
SGK1 98 20
S6K1 98 1
PKA 111 16
ROCK 2 99 6
PRK2 86 6
PKC alpha 96 5
PKC gamma 88 6
PKC zeta 91 2
PKD1 89 2
STK33 34 0
MSK1 93 2
MNK1 99 14
MNK2 87 6
MAPKAP-K2 87 5
MAPKAP-K3 113 1
PRAK 97 2
CAMKK beta 81 2
CAMK1 78 11
SmMLCK 88 2
PHK 55 0
DAPK1 92 3
CHK1 91 2
CHK2 37 0
GSK3 beta 109 6
CDK2-Cyclin A 110 32
CDK9-Cyclin T1 101 8
PLK1 97 12
Aurora A 95 2
Aurora B 93 13
TLK1 63 13
LKB1 84 13
AMPK (hum) 65 4
MARK1 84 5
MARK2 89 8
MARK3 74 10
MARK4 101 7
BRSK1 101 1
BRSK2 107 12
MELK 95 10
NUAK1 63 12
SIK2 8 0
SIK3 9 0
TSSK1 67 1
CK1 gamma 2 117 1
CK1 delta 86 20
CK2 77 3
TTBK1 95 2
TTBK2 87 6
DYRK1A 91 3
DYRK2 71 4
DYRK3 85 11
NEK2a 76 4
NEK6 102 1
IKK beta 92 15
IKK epsilon 46 7
TBK1 75 1
PIM1 91 7
PIM2 99 0
PIM3 92 16
SRPK1 89 6
EF2K 81 2
EIF2AK3 107 5
HIPK1 95 0
HIPK2 71 7
HIPK3 102 14
CLK2 75 9
PAK2 115 6
PAK4 110 16
PAK5 105 18
PAK6 103 11
MST2 65 6
MST3 68 0
MST4 20 1
GCK 9 2
MAP4K3 3 0
MAP4K5 0 2
MINK1 5 1
MEKK1 95 5
MLK1 52 9
MLK3 42 4
TESK1 82 15
TAO1 85 8
ASK1 96 9
TAK1 41 9
IRAK1 77 3
IRAK4 55 3
RIPK2 86 2
OSR1 96 3
TTK 94 0
MPSK1 117 15
WNK1 102 2
ULK1 79 5
ULK2 78 10
TGFBR1 87 14
Src 1 0
Lck 1 0
CSK 65 7
YES1 2 1
ABL 1 0
BTK 1 0
JAK2 72 5
SYK 77 2
ZAP70 99 4
TIE2 74 3
BRK 88 11
EPH-A2 4 0
EPH-A4 3 1
EPH-B1 12 0
EPH-B2 1 1
EPH-B3 16 0
EPH-B4 10 0
FGF-R1 94 4
HER4 9 0
IGF-1R 89 8
IR 87 7
IRR 72 5
TrkA 25 2
DDR2 22 1
VEGFR1 88 5
PDGFRA 96 1
PINK 112 9
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 31 9
MKK2 21 4
MKK6 115 5
ERK1 103 1
ERK2 103 15
ERK5 67 10
JNK1 102 1
JNK2 108 11
JNK3 106 10
p38 alpha MAPK 72 3
p38 beta MAPK 108 24
p38 gamma MAPK 109 5
p38 delta MAPK 116 12
ERK8 87 3
RSK1 70 3
RSK2 64 1
PDK1 98 0
PKB alpha 116 30
PKB beta 90 3
SGK1 100 2
S6K1 86 2
PKA 105 7
ROCK 2 74 7
PRK2 56 3
PKC alpha 103 3
PKC gamma 102 5
PKC zeta 102 4
PKD1 86 8
STK33 17 4
MSK1 102 12
MNK1 105 2
MNK2 100 9
MAPKAP-K2 94 5
MAPKAP-K3 103 8
PRAK 125 1
CAMKK beta 27 0
CAMK1 74 16
SmMLCK 27 1
PHK 12 0
DAPK1 105 4
CHK1 57 0
CHK2 10 2
GSK3 beta 114 22
CDK2-Cyclin A 103 5
CDK9-Cyclin T1 125 16
PLK1 74 6
Aurora A 98 6
Aurora B 50 7
TLK1 35 3
LKB1 104 15
AMPK (hum) 26 2
MARK1 76 4
MARK2 68 1
MARK3 41 3
MARK4 72 5
BRSK1 112 5
BRSK2 120 4
MELK 66 1
NUAK1 21 2
SIK2 3 0
SIK3 2 0
TSSK1 22 2
CK1 gamma 2 108 4
CK1 delta 60 7
CK2 106 1
TTBK1 114 3
TTBK2 92 6
DYRK1A 96 13
DYRK2 87 5
DYRK3 90 16
NEK2a 63 2
NEK6 111 3
IKK beta 86 8
IKK epsilon 6 0
TBK1 29 1
PIM1 94 0
PIM2 96 8
PIM3 101 3
SRPK1 109 5
EF2K 95 6
EIF2AK3 103 0
HIPK1 57 0
HIPK2 42 4
HIPK3 66 5
CLK2 23 0
PAK2 108 1
PAK4 126 1
PAK5 129 5
PAK6 132 7
MST2 17 2
MST3 21 4
MST4 7 0
GCK 4 0
MAP4K3 1 0
MAP4K5 1 0
MINK1 1 0
MEKK1 85 6
MLK1 18 4
MLK3 8 1
TESK1 61 2
TAO1 102 7
ASK1 106 1
TAK1 5 0
IRAK1 65 0
IRAK4 23 0
RIPK2 45 1
OSR1 65 2
TTK 99 7
MPSK1 110 11
WNK1 104 9
ULK1 44 2
ULK2 37 1
TGFBR1 101 6
Src 1 0
Lck 1 0
CSK 4 0
YES1 1 0
ABL 0 0
BTK 1 0
JAK2 26 0
SYK 39 1
ZAP70 109 18
TIE2 64 3
BRK 48 0
EPH-A2 1 0
EPH-A4 1 0
EPH-B1 0 2
EPH-B2 0 0
EPH-B3 1 0
EPH-B4 2 0
FGF-R1 74 6
HER4 1 1
IGF-1R 79 4
IR 107 34
IRR 59 1
TrkA 7 0
DDR2 2 0
VEGFR1 54 3
PDGFRA 79 0
PINK 125 13

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