Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Dasatinib C22H26ClN7O2S 487 BCR-ABL, Src Kantarjian H. N Engl J Med. (2010) 2260-70 WO2009094556 Cayman Chemical Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 118 10
MKK2 113 11
MKK6 104 11
ERK1 91 6
ERK2 93 9
ERK5 87 2
JNK1 108 4
JNK2 110 10
JNK3 108 0
p38 alpha MAPK 79 15
p38 beta MAPK 105 11
p38 gamma MAPK 100 4
p38 delta MAPK 118 17
ERK8 90 14
RSK1 105 2
RSK2 86 9
PDK1 94 9
PKB alpha 103 15
PKB beta 94 11
SGK1 87 11
S6K1 108 3
PKA 110 12
ROCK 2 130 10
PRK2 100 2
PKC alpha 98 3
PKC gamma 107 22
PKC zeta 101 3
PKD1 92 21
STK33 105 6
MSK1 94 4
MNK1 108 0
MNK2 97 8
MAPKAP-K2 114 4
MAPKAP-K3 117 3
PRAK 129 14
CAMKK beta 96 4
CAMK1 89 16
SmMLCK 111 4
PHK 101 10
DAPK1 126 10
CHK1 100 6
CHK2 98 8
GSK3 beta 103 2
CDK2-Cyclin A 116 1
CDK9-Cyclin T1 122 8
PLK1 133 18
Aurora A 94 0
Aurora B 120 10
TLK1 96 4
LKB1 96 18
AMPK (hum) 107 13
MARK1 115 3
MARK2 118 4
MARK3 96 16
MARK4 105 12
BRSK1 126 0
BRSK2 102 14
MELK 112 7
NUAK1 119 10
SIK2 4 1
SIK3 9 2
TSSK1 106 11
CK1 gamma 2 115 0
CK1 delta 113 4
CK2 95 3
TTBK1 112 8
TTBK2 110 5
DYRK1A 111 4
DYRK2 101 5
DYRK3 98 7
NEK2a 122 11
NEK6 113 4
IKK beta 97 21
IKK epsilon 102 5
TBK1 100 1
PIM1 90 1
PIM2 104 3
PIM3 96 8
SRPK1 104 9
EF2K 104 4
EIF2AK3 106 6
HIPK1 105 4
HIPK2 95 1
HIPK3 102 3
CLK2 120 6
PAK2 118 2
PAK4 137 21
PAK5 131 12
PAK6 126 9
MST2 75 2
MST3 114 20
MST4 97 10
GCK 95 7
MAP4K3 88 15
MAP4K5 22 1
MINK1 90 4
MEKK1 98 4
MLK1 72 1
MLK3 76 10
TESK1 50 3
TAO1 120 9
ASK1 108 7
TAK1 97 23
IRAK1 96 1
IRAK4 112 24
RIPK2 5 0
OSR1 100 1
TTK 104 6
MPSK1 101 5
WNK1 104 4
ULK1 95 9
ULK2 101 3
TGFBR1 103 1
Src 1 0
Lck 1 0
CSK 97 19
YES1 1 0
ABL 0 0
BTK 1 0
JAK2 94 2
SYK 97 1
ZAP70 109 1
TIE2 88 7
BRK 5 0
EPH-A2 1 0
EPH-A4 2 0
EPH-B1 -1 1
EPH-B2 1 0
EPH-B3 1 0
EPH-B4 20 0
FGF-R1 88 7
HER4 27 1
IGF-1R 107 6
IR 99 2
IRR 89 4
TrkA 107 11
DDR2 1 1
VEGFR1 78 9
PDGFRA 6 1
PINK 117 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 134 16
MKK2 91 0
MKK6 112 4
ERK1 114 12
ERK2 102 1
ERK5 91 4
JNK1 121 9
JNK2 125 0
JNK3 113 15
p38 alpha MAPK 29 2
p38 beta MAPK 44 4
p38 gamma MAPK 105 7
p38 delta MAPK 133 1
ERK8 95 11
RSK1 102 5
RSK2 101 3
PDK1 92 1
PKB alpha 120 13
PKB beta 94 2
SGK1 96 7
S6K1 113 11
PKA 121 27
ROCK 2 132 7
PRK2 101 0
PKC alpha 105 14
PKC gamma 114 22
PKC zeta 109 7
PKD1 107 15
STK33 110 4
MSK1 103 1
MNK1 102 9
MNK2 106 2
MAPKAP-K2 111 7
MAPKAP-K3 132 1
PRAK 128 7
CAMKK beta 99 19
CAMK1 77 1
SmMLCK 111 7
PHK 103 1
DAPK1 102 7
CHK1 96 6
CHK2 102 1
GSK3 beta 121 12
CDK2-Cyclin A 112 1
CDK9-Cyclin T1 138 12
PLK1 99 15
Aurora A 101 1
Aurora B 108 10
TLK1 124 0
LKB1 100 14
AMPK (hum) 120 5
MARK1 127 3
MARK2 126 2
MARK3 104 5
MARK4 115 24
BRSK1 123 1
BRSK2 108 13
MELK 128 7
NUAK1 118 8
SIK2 2 1
SIK3 2 0
TSSK1 113 3
CK1 gamma 2 113 12
CK1 delta 124 1
CK2 80 28
TTBK1 112 1
TTBK2 117 7
DYRK1A 126 19
DYRK2 117 9
DYRK3 104 9
NEK2a 98 4
NEK6 123 6
IKK beta 99 9
IKK epsilon 123 13
TBK1 97 10
PIM1 98 1
PIM2 105 1
PIM3 108 5
SRPK1 107 9
EF2K 95 5
EIF2AK3 113 2
HIPK1 122 6
HIPK2 97 5
HIPK3 113 7
CLK2 121 6
PAK2 119 12
PAK4 132 16
PAK5 138 7
PAK6 120 4
MST2 81 6
MST3 93 2
MST4 77 4
GCK 56 8
MAP4K3 54 1
MAP4K5 3 1
MINK1 51 1
MEKK1 102 1
MLK1 41 2
MLK3 39 6
TESK1 8 0
TAO1 95 7
ASK1 118 7
TAK1 99 7
IRAK1 108 3
IRAK4 102 6
RIPK2 10 12
OSR1 101 0
TTK 109 9
MPSK1 123 1
WNK1 104 12
ULK1 101 0
ULK2 91 3
TGFBR1 82 5
Src 2 0
Lck 1 0
CSK 8 3
YES1 1 0
ABL 0 0
BTK 1 0
JAK2 42 1
SYK 90 0
ZAP70 121 27
TIE2 78 5
BRK 2 0
EPH-A2 1 0
EPH-A4 2 2
EPH-B1 -1 2
EPH-B2 1 0
EPH-B3 1 0
EPH-B4 3 0
FGF-R1 84 6
HER4 6 0
IGF-1R 98 7
IR 94 7
IRR 90 14
TrkA 88 2
DDR2 0 0
VEGFR1 53 4
PDGFRA 3 1
PINK 133 5

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