Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Celastrol C29H38O4 450.6 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13 WO2007117466 Cayman Chemical Download

Results as Barchart

View results as a bar chart
5µM
1µM

Results as Table

Screening Concentration: 5µM
Kinase % Activity Remainingsort ascending Standard Deviation
PKC zeta 174 7
IRAK4 142 7
HER4 140 5
OSR1 138 4
EPH-B1 133 33
ASK1 133 8
SYK 131 6
CK1 delta 130 43
CHK1 129 8
MST3 122 2
EPH-B4 121 10
RIPK2 121 4
MKK6 120 1
MPSK1 120 8
p38 delta MAPK 119 0
NEK2a 118 8
MNK1 117 2
EPH-B2 116 24
TBK1 116 1
PKA 115 9
GSK3 beta 115 1
ZAP70 114 4
MAPKAP-K2 113 2
PAK6 113 6
BRK 113 5
EPH-B3 112 28
EF2K 111 7
PIM2 111 14
TTBK1 110 2
IGF-1R 110 17
DDR2 110 6
MAP4K5 108 1
MEKK1 108 1
CAMKK beta 108 1
MNK2 107 10
ERK1 107 3
JNK1 107 10
p38 gamma MAPK 107 11
HIPK2 106 4
TAO1 106 12
BTK 106 11
p38 alpha MAPK 105 6
MINK1 104 15
ULK2 104 16
Lck 104 10
SmMLCK 104 5
ULK1 103 1
CK2 103 4
CAMK1 103 2
ROCK 2 103 9
JAK2 103 1
PDGFRA 103 3
PKC alpha 102 0
CDK9-Cyclin T1 102 3
JNK2 101 23
PHK 100 4
EIF2AK3 99 2
YES1 99 7
PIM1 99 1
PIM3 98 6
ABL 98 8
IRAK1 98 6
TIE2 98 10
WNK1 97 2
TGFBR1 97 9
DAPK1 97 1
STK33 97 1
CK1 gamma 2 96 3
SRPK1 96 5
DYRK1A 96 13
ERK5 96 11
MSK1 95 3
MST2 95 1
p38 beta MAPK 95 0
TLK1 94 5
LKB1 94 6
PAK2 94 1
Aurora A 93 3
MELK 93 7
MARK3 92 6
PKB alpha 91 17
TTBK2 91 13
TESK1 91 24
CLK2 91 1
IR 91 4
EPH-A4 90 10
Src 90 2
PDK1 89 1
HIPK1 89 0
MLK1 89 8
CSK 89 1
GCK 89 6
MKK1 88 1
MARK2 88 8
DYRK2 88 23
EPH-A2 88 17
PAK4 86 7
PRK2 85 4
RSK1 84 2
NUAK1 84 3
TAK1 83 4
IRR 83 6
PAK5 83 3
CDK2-Cyclin A 83 5
PKB beta 82 3
JNK3 82 11
CHK2 82 1
MST4 82 6
BRSK1 81 0
PINK 81 8
SGK1 80 3
NEK6 78 1
HIPK3 77 13
MARK1 76 6
PKD1 75 5
AMPK (hum) 74 6
IKK beta 74 3
MKK2 71 4
TTK 71 4
S6K1 70 5
SIK2 69 6
PLK1 68 18
IKK epsilon 67 4
TrkA 66 12
MAPKAP-K3 64 1
SIK3 64 2
FGF-R1 63 8
RSK2 60 7
ERK8 58 1
MARK4 57 2
PKC gamma 52 6
MAP4K3 50 14
VEGFR1 49 6
PRAK 45 8
TSSK1 42 1
ERK2 39 1
MLK3 30 5
DYRK3 23 6
BRSK2 23 1
Aurora B 11 2
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
IGF-1R 117 8
DDR2 116 13
OSR1 116 22
TTBK2 115 5
PKC zeta 115 11
TTBK1 113 2
MKK6 111 0
MST2 111 12
Src 110 3
MST3 110 3
PIM3 110 6
MST4 109 8
BTK 108 6
IRAK4 108 11
PIM2 108 1
ULK2 107 12
ASK1 106 1
JNK1 106 2
BRSK1 106 13
MAPKAP-K2 104 11
PAK5 103 12
CK1 gamma 2 103 6
MEKK1 103 1
NEK2a 102 3
p38 beta MAPK 102 1
DYRK1A 101 4
S6K1 101 7
YES1 101 9
IKK beta 101 10
BRK 101 5
PKB alpha 100 28
HER4 100 7
TAO1 100 13
PAK2 100 2
PDGFRA 100 2
EPH-B4 99 9
PKA 99 0
CHK2 99 3
IKK epsilon 99 8
GSK3 beta 99 2
TBK1 99 11
EPH-A2 99 11
ULK1 99 16
MAPKAP-K3 98 3
PAK4 98 13
MPSK1 98 11
EPH-A4 98 14
EPH-B2 98 6
HIPK3 97 4
PINK 97 12
MINK1 97 9
PDK1 97 9
CK2 97 6
HIPK2 96 6
MARK3 96 2
IR 96 15
JNK2 96 23
PAK6 96 12
NUAK1 96 17
Aurora A 96 0
TGFBR1 96 8
ERK1 95 16
STK33 95 4
HIPK1 94 11
CHK1 94 8
RIPK2 94 8
SIK3 94 16
Lck 93 10
ABL 93 0
IRR 93 8
PRK2 93 13
IRAK1 93 5
p38 alpha MAPK 93 3
TIE2 93 4
CLK2 92 9
PHK 92 3
MARK4 92 7
PKC alpha 92 7
PIM1 92 3
PLK1 92 7
MAP4K3 92 1
SRPK1 92 2
MAP4K5 92 10
EPH-B3 92 22
AMPK (hum) 91 5
WNK1 91 8
MNK2 91 10
TESK1 90 6
MSK1 90 3
MKK2 89 2
PKB beta 89 1
MARK1 89 3
DYRK3 89 9
JAK2 89 6
MNK1 89 8
MKK1 89 4
SGK1 88 0
DAPK1 88 17
NEK6 88 6
MELK 88 27
CK1 delta 88 7
CDK9-Cyclin T1 87 17
EF2K 87 8
EIF2AK3 87 6
ERK2 86 12
CAMK1 86 8
MARK2 86 6
MLK1 85 6
TAK1 85 7
SIK2 85 4
CDK2-Cyclin A 84 1
LKB1 83 3
SmMLCK 83 5
ROCK 2 83 5
TTK 83 3
CAMKK beta 82 4
ERK5 82 0
SYK 81 19
RSK1 81 2
TLK1 81 5
p38 delta MAPK 80 6
CSK 79 0
PKD1 79 1
FGF-R1 78 7
ZAP70 78 10
EPH-B1 78 1
VEGFR1 77 18
JNK3 76 2
TrkA 74 10
GCK 73 1
RSK2 72 8
DYRK2 71 10
p38 gamma MAPK 71 18
Aurora B 67 7
MLK3 66 3
BRSK2 65 0
PRAK 63 5
PKC gamma 63 12
ERK8 62 5
TSSK1 60 6

Do you need any help? Please get in touch and we’ll be happy to lend a hand.