Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Celastrol C29H38O4 450.6 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13 WO2007117466 Cayman Chemical Download

Results as Barchart

View results as a bar chart
5µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 89 4
MKK2 89 2
MKK6 111 0
ERK1 95 16
ERK2 86 12
ERK5 82 0
JNK1 106 2
JNK2 96 23
JNK3 76 2
p38 alpha MAPK 93 3
p38 beta MAPK 102 1
p38 gamma MAPK 71 18
p38 delta MAPK 80 6
ERK8 62 5
RSK1 81 2
RSK2 72 8
PDK1 97 9
PKB alpha 100 28
PKB beta 89 1
SGK1 88 0
S6K1 101 7
PKA 99 0
ROCK 2 83 5
PRK2 93 13
PKC alpha 92 7
PKC gamma 63 12
PKC zeta 115 11
PKD1 79 1
STK33 95 4
MSK1 90 3
MNK1 89 8
MNK2 91 10
MAPKAP-K2 104 11
MAPKAP-K3 98 3
PRAK 63 5
CAMKK beta 82 4
CAMK1 86 8
SmMLCK 83 5
PHK 92 3
DAPK1 88 17
CHK1 94 8
CHK2 99 3
GSK3 beta 99 2
CDK2-Cyclin A 84 1
CDK9-Cyclin T1 87 17
PLK1 92 7
Aurora A 96 0
Aurora B 67 7
TLK1 81 5
LKB1 83 3
AMPK (hum) 91 5
MARK1 89 3
MARK2 86 6
MARK3 96 2
MARK4 92 7
BRSK1 106 13
BRSK2 65 0
MELK 88 27
NUAK1 96 17
SIK2 85 4
SIK3 94 16
TSSK1 60 6
CK1 gamma 2 103 6
CK1 delta 88 7
CK2 97 6
TTBK1 113 2
TTBK2 115 5
DYRK1A 101 4
DYRK2 71 10
DYRK3 89 9
NEK2a 102 3
NEK6 88 6
IKK beta 101 10
IKK epsilon 99 8
TBK1 99 11
PIM1 92 3
PIM2 108 1
PIM3 110 6
SRPK1 92 2
EF2K 87 8
EIF2AK3 87 6
HIPK1 94 11
HIPK2 96 6
HIPK3 97 4
CLK2 92 9
PAK2 100 2
PAK4 98 13
PAK5 103 12
PAK6 96 12
MST2 111 12
MST3 110 3
MST4 109 8
GCK 73 1
MAP4K3 92 1
MAP4K5 92 10
MINK1 97 9
MEKK1 103 1
MLK1 85 6
MLK3 66 3
TESK1 90 6
TAO1 100 13
ASK1 106 1
TAK1 85 7
IRAK1 93 5
IRAK4 108 11
RIPK2 94 8
OSR1 116 22
TTK 83 3
MPSK1 98 11
WNK1 91 8
ULK1 99 16
ULK2 107 12
TGFBR1 96 8
Src 110 3
Lck 93 10
CSK 79 0
YES1 101 9
ABL 93 0
BTK 108 6
JAK2 89 6
SYK 81 19
ZAP70 78 10
TIE2 93 4
BRK 101 5
EPH-A2 99 11
EPH-A4 98 14
EPH-B1 78 1
EPH-B2 98 6
EPH-B3 92 22
EPH-B4 99 9
FGF-R1 78 7
HER4 100 7
IGF-1R 117 8
IR 96 15
IRR 93 8
TrkA 74 10
DDR2 116 13
VEGFR1 77 18
PDGFRA 100 2
PINK 97 12
Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 88 1
MKK2 71 4
MKK6 120 1
ERK1 107 3
ERK2 39 1
ERK5 96 11
JNK1 107 10
JNK2 101 23
JNK3 82 11
p38 alpha MAPK 105 6
p38 beta MAPK 95 0
p38 gamma MAPK 107 11
p38 delta MAPK 119 0
ERK8 58 1
RSK1 84 2
RSK2 60 7
PDK1 89 1
PKB alpha 91 17
PKB beta 82 3
SGK1 80 3
S6K1 70 5
PKA 115 9
ROCK 2 103 9
PRK2 85 4
PKC alpha 102 0
PKC gamma 52 6
PKC zeta 174 7
PKD1 75 5
STK33 97 1
MSK1 95 3
MNK1 117 2
MNK2 107 10
MAPKAP-K2 113 2
MAPKAP-K3 64 1
PRAK 45 8
CAMKK beta 108 1
CAMK1 103 2
SmMLCK 104 5
PHK 100 4
DAPK1 97 1
CHK1 129 8
CHK2 82 1
GSK3 beta 115 1
CDK2-Cyclin A 83 5
CDK9-Cyclin T1 102 3
PLK1 68 18
Aurora A 93 3
Aurora B 11 2
TLK1 94 5
LKB1 94 6
AMPK (hum) 74 6
MARK1 76 6
MARK2 88 8
MARK3 92 6
MARK4 57 2
BRSK1 81 0
BRSK2 23 1
MELK 93 7
NUAK1 84 3
SIK2 69 6
SIK3 64 2
TSSK1 42 1
CK1 gamma 2 96 3
CK1 delta 130 43
CK2 103 4
TTBK1 110 2
TTBK2 91 13
DYRK1A 96 13
DYRK2 88 23
DYRK3 23 6
NEK2a 118 8
NEK6 78 1
IKK beta 74 3
IKK epsilon 67 4
TBK1 116 1
PIM1 99 1
PIM2 111 14
PIM3 98 6
SRPK1 96 5
EF2K 111 7
EIF2AK3 99 2
HIPK1 89 0
HIPK2 106 4
HIPK3 77 13
CLK2 91 1
PAK2 94 1
PAK4 86 7
PAK5 83 3
PAK6 113 6
MST2 95 1
MST3 122 2
MST4 82 6
GCK 89 6
MAP4K3 50 14
MAP4K5 108 1
MINK1 104 15
MEKK1 108 1
MLK1 89 8
MLK3 30 5
TESK1 91 24
TAO1 106 12
ASK1 133 8
TAK1 83 4
IRAK1 98 6
IRAK4 142 7
RIPK2 121 4
OSR1 138 4
TTK 71 4
MPSK1 120 8
WNK1 97 2
ULK1 103 1
ULK2 104 16
TGFBR1 97 9
Src 90 2
Lck 104 10
CSK 89 1
YES1 99 7
ABL 98 8
BTK 106 11
JAK2 103 1
SYK 131 6
ZAP70 114 4
TIE2 98 10
BRK 113 5
EPH-A2 88 17
EPH-A4 90 10
EPH-B1 133 33
EPH-B2 116 24
EPH-B3 112 28
EPH-B4 121 10
FGF-R1 63 8
HER4 140 5
IGF-1R 110 17
IR 91 4
IRR 83 6
TrkA 66 12
DDR2 110 6
VEGFR1 49 6
PDGFRA 103 3
PINK 81 8

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