Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Metformin C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11 Sigma Download

Results as Barchart

View results as a bar chart
250µM
100µM

Results as Table

Screening Concentration: 100µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 6
MKK2 98 9
MKK6 79 3
ERK1 95 2
ERK2 96 1
ERK5 87 1
JNK1 90 8
JNK2 75 1
JNK3 92 14
p38 alpha MAPK 80 1
p38 beta MAPK 101 6
p38 gamma MAPK 85 3
p38 delta MAPK 89 4
ERK8 85 8
RSK1 88 11
RSK2 84 3
PDK1 90 6
PKB alpha 101 2
PKB beta 96 4
SGK1 88 1
S6K1 97 6
PKA 94 9
ROCK 2 89 4
PRK2 96 3
PKC alpha 118 24
PKC gamma 88 9
PKC zeta 104 7
PKD1 89 0
STK33 94 9
MSK1 92 11
MNK1 92 3
MNK2 98 11
MAPKAP-K2 93 1
MAPKAP-K3 91 7
PRAK 104 7
CAMKK beta 92 7
CAMK1 86 10
SmMLCK 93 1
PHK 103 6
DAPK1 91 1
CHK1 93 1
CHK2 97 4
GSK3 beta 88 7
CDK2-Cyclin A 96 2
CDK9-Cyclin T1 78 7
PLK1 95 8
Aurora A 102 7
Aurora B 76 4
TLK1 90 5
LKB1 95 26
AMPK (hum) 92 5
MARK1 93 12
MARK2 98 4
MARK3 95 8
MARK4 94 9
BRSK1 88 1
BRSK2 81 0
MELK 100 14
NUAK1 81 16
SIK2 90 1
SIK3 94 10
TSSK1 81 4
CK1 gamma 2 91 9
CK1 delta 89 2
CK2 88 1
TTBK1 93 5
TTBK2 91 4
DYRK1A 89 18
DYRK2 91 9
DYRK3 97 4
NEK2a 106 9
NEK6 88 34
IKK beta 97 0
IKK epsilon 86 6
TBK1 81 4
PIM1 103 1
PIM2 103 15
PIM3 89 1
SRPK1 82 3
EF2K 86 0
EIF2AK3 82 1
HIPK1 90 1
HIPK2 94 1
HIPK3 96 8
CLK2 94 12
PAK2 98 1
PAK4 91 19
PAK5 102 6
PAK6 107 9
MST2 107 13
MST3 88 2
MST4 97 7
GCK 87 4
MAP4K3 94 17
MAP4K5 91 15
MINK1 74 9
MEKK1 92 6
MLK1 92 3
MLK3 83 1
TESK1 96 1
TAO1 87 14
ASK1 98 0
TAK1 96 1
IRAK1 111 3
IRAK4 134 59
RIPK2 95 4
OSR1 97 16
TTK 108 6
MPSK1 87 3
WNK1 92 20
ULK1 93 3
ULK2 106 6
TGFBR1 93 2
Src 87 8
Lck 97 10
CSK 88 1
YES1 96 14
ABL 96 2
BTK 78 32
JAK2 85 3
SYK 74 10
ZAP70 89 1
TIE2 90 7
BRK 81 1
EPH-A2 81 4
EPH-A4 89 10
EPH-B1 82 5
EPH-B2 99 1
EPH-B3 93 2
EPH-B4 63 5
FGF-R1 79 2
HER4 77 17
IGF-1R 129 7
IR 95 4
IRR 97 2
TrkA 80 11
DDR2 109 10
VEGFR1 89 6
PDGFRA 97 3
PINK 96 6
Screening Concentration: 250µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 10
MKK2 101 13
MKK6 78 1
ERK1 102 10
ERK2 100 11
ERK5 94 2
JNK1 99 2
JNK2 92 7
JNK3 100 8
p38 alpha MAPK 93 8
p38 beta MAPK 100 4
p38 gamma MAPK 87 11
p38 delta MAPK 101 5
ERK8 101 2
RSK1 94 13
RSK2 83 1
PDK1 100 6
PKB alpha 98 1
PKB beta 108 4
SGK1 102 1
S6K1 102 2
PKA 97 4
ROCK 2 94 2
PRK2 95 6
PKC alpha 91 5
PKC gamma 103 9
PKC zeta 99 6
PKD1 94 6
STK33 100 11
MSK1 104 7
MNK1 95 3
MNK2 93 3
MAPKAP-K2 107 17
MAPKAP-K3 95 12
PRAK 100 5
CAMKK beta 88 4
CAMK1 86 5
SmMLCK 91 3
PHK 100 3
DAPK1 93 1
CHK1 93 2
CHK2 93 2
GSK3 beta 93 14
CDK2-Cyclin A 113 0
CDK9-Cyclin T1 92 0
PLK1 128 11
Aurora A 100 5
Aurora B 83 5
TLK1 96 4
LKB1 113 7
AMPK (hum) 97 9
MARK1 94 3
MARK2 101 3
MARK3 95 17
MARK4 93 2
BRSK1 95 4
BRSK2 93 1
MELK 95 1
NUAK1 93 18
SIK2 96 3
SIK3 87 5
TSSK1 90 0
CK1 gamma 2 104 10
CK1 delta 87 3
CK2 100 4
TTBK1 92 3
TTBK2 90 10
DYRK1A 93 2
DYRK2 84 3
DYRK3 109 5
NEK2a 101 5
NEK6 84 7
IKK beta 96 6
IKK epsilon 82 3
TBK1 86 4
PIM1 94 1
PIM2 99 13
PIM3 90 4
SRPK1 95 1
EF2K 101 5
EIF2AK3 87 5
HIPK1 93 8
HIPK2 112 18
HIPK3 107 12
CLK2 89 3
PAK2 103 9
PAK4 88 1
PAK5 91 8
PAK6 95 10
MST2 112 5
MST3 98 1
MST4 107 11
GCK 95 1
MAP4K3 87 1
MAP4K5 95 10
MINK1 75 4
MEKK1 89 11
MLK1 106 17
MLK3 83 2
TESK1 86 7
TAO1 104 7
ASK1 97 1
TAK1 101 10
IRAK1 111 3
IRAK4 98 3
RIPK2 107 4
OSR1 99 6
TTK 108 14
MPSK1 95 4
WNK1 97 14
ULK1 97 10
ULK2 110 2
TGFBR1 100 11
Src 86 3
Lck 89 1
CSK 92 3
YES1 96 17
ABL 94 11
BTK 74 27
JAK2 73 5
SYK 80 5
ZAP70 93 0
TIE2 82 10
BRK 90 2
EPH-A2 104 24
EPH-A4 95 10
EPH-B1 98 5
EPH-B2 112 8
EPH-B3 103 4
EPH-B4 77 3
FGF-R1 82 4
HER4 81 0
IGF-1R 122 5
IR 94 4
IRR 97 7
TrkA 78 11
DDR2 99 6
VEGFR1 89 4
PDGFRA 92 1
PINK 108 3

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