Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
VPS34-IN2 (PIK-III) C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology WO2012085815

We found VPS34-IN1 (PMID: 25177796) slightly more selective and effective at inhibiting SGK3 than VPS34-IN2. We would recommend the use of VPS34-IN1 for in vivo work.

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0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 3
MKK2 80 3
MKK6 88 23
ERK1 91 7
ERK2 72 6
ERK5 70 1
JNK1 77 13
JNK2 74 8
JNK3 92 7
p38 alpha MAPK 92 1
p38 beta MAPK 87 12
p38 gamma MAPK 76 1
p38 delta MAPK 83 0
ERK8 15 1
RSK1 91 4
RSK2 75 9
PDK1 90 3
PKB alpha 83 11
PKB beta 96 5
SGK1 94 1
S6K1 78 3
PKA 94 7
ROCK 2 78 7
PRK2 72 1
PKC alpha 91 10
PKC gamma 94 11
PKC zeta 112 8
PKD1 89 10
STK33 89 6
MSK1 86 1
MNK1 76 10
MNK2 92 4
MAPKAP-K2 99 5
MAPKAP-K3 95 7
PRAK 87 2
CAMKK beta 94 8
CAMK1 87 7
SmMLCK 84 1
PHK 101 7
DAPK1 85 5
CHK1 90 12
CHK2 94 6
GSK3 beta 67 9
CDK2-Cyclin A 52 2
CDK9-Cyclin T1 76 1
PLK1 87 8
Aurora A 91 24
Aurora B 39 8
TLK1 83 8
LKB1 85 6
AMPK (hum) 82 8
MARK1 64 3
MARK2 90 15
MARK3 70 8
MARK4 87 0
BRSK1 76 1
BRSK2 102 4
MELK 76 2
NUAK1 68 6
SIK2 67 4
SIK3 79 4
TSSK1 81 3
CK1 gamma 2 93 4
CK1 delta 63 5
CK2 92 5
TTBK1 81 7
TTBK2 87 13
DYRK1A 85 0
DYRK2 96 18
DYRK3 88 7
NEK2a 99 4
NEK6 84 3
IKK beta 82 4
IKK epsilon 82 2
TBK1 91 2
PIM1 90 1
PIM2 94 6
PIM3 91 13
SRPK1 81 5
EF2K 89 6
EIF2AK3 84 2
HIPK1 74 1
HIPK2 78 4
HIPK3 87 4
CLK2 67 11
PAK2 85 1
PAK4 75 9
PAK5 83 7
PAK6 93 7
MST2 69 4
MST3 78 4
MST4 74 1
GCK 73 1
MAP4K3 78 7
MAP4K5 74 6
MINK1 64 8
MEKK1 91 5
MLK1 81 13
MLK3 52 9
TESK1 81 6
TAO1 48 6
ASK1 102 3
TAK1 47 7
IRAK1 88 3
IRAK4 68 9
RIPK2 58 6
OSR1 90 1
TTK 84 1
MPSK1 84 1
WNK1 96 7
ULK1 81 10
ULK2 98 10
TGFBR1 79 3
Src 87 10
Lck 83 0
CSK 136 39
YES1 80 11
ABL 92 5
BTK 84 2
JAK2 30 1
SYK 92 4
ZAP70 93 5
TIE2 72 14
BRK 51 5
EPH-A2 92 1
EPH-A4 92 3
EPH-B1 90 7
EPH-B2 81 16
EPH-B3 97 8
EPH-B4 104 3
FGF-R1 85 5
HER4 86 14
IGF-1R 76 5
IR 79 12
IRR 90 7
TrkA 92 24
DDR2 91 18
VEGFR1 70 1
PDGFRA 97 2
PINK 85 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 83 0
MKK2 81 7
MKK6 86 11
ERK1 82 5
ERK2 91 1
ERK5 95 11
JNK1 87 6
JNK2 82 6
JNK3 102 11
p38 alpha MAPK 101 3
p38 beta MAPK 88 9
p38 gamma MAPK 79 2
p38 delta MAPK 89 2
ERK8 53 2
RSK1 86 11
RSK2 83 6
PDK1 88 11
PKB alpha 83 9
PKB beta 90 9
SGK1 83 14
S6K1 82 6
PKA 94 6
ROCK 2 75 3
PRK2 81 1
PKC alpha 86 5
PKC gamma 100 4
PKC zeta 101 4
PKD1 94 10
STK33 88 14
MSK1 95 3
MNK1 84 6
MNK2 95 6
MAPKAP-K2 96 2
MAPKAP-K3 94 1
PRAK 92 6
CAMKK beta 100 3
CAMK1 103 3
SmMLCK 95 2
PHK 100 8
DAPK1 94 1
CHK1 98 9
CHK2 92 0
GSK3 beta 87 3
CDK2-Cyclin A 78 9
CDK9-Cyclin T1 92 1
PLK1 86 13
Aurora A 96 11
Aurora B 65 8
TLK1 93 10
LKB1 92 1
AMPK (hum) 98 21
MARK1 79 5
MARK2 93 10
MARK3 81 5
MARK4 95 5
BRSK1 91 0
BRSK2 105 4
MELK 88 3
NUAK1 90 3
SIK2 85 1
SIK3 90 1
TSSK1 110 12
CK1 gamma 2 105 21
CK1 delta 92 1
CK2 97 5
TTBK1 95 10
TTBK2 83 11
DYRK1A 90 2
DYRK2 115 13
DYRK3 96 1
NEK2a 99 1
NEK6 95 1
IKK beta 93 4
IKK epsilon 83 5
TBK1 93 8
PIM1 90 8
PIM2 89 7
PIM3 93 3
SRPK1 85 3
EF2K 103 9
EIF2AK3 110 5
HIPK1 81 6
HIPK2 82 6
HIPK3 87 0
CLK2 83 4
PAK2 96 4
PAK4 113 2
PAK5 84 3
PAK6 101 8
MST2 85 13
MST3 88 22
MST4 82 5
GCK 78 13
MAP4K3 87 15
MAP4K5 87 10
MINK1 70 0
MEKK1 83 2
MLK1 101 10
MLK3 78 4
TESK1 106 24
TAO1 79 12
ASK1 100 9
TAK1 77 7
IRAK1 93 3
IRAK4 96 6
RIPK2 85 3
OSR1 91 2
TTK 88 6
MPSK1 105 8
WNK1 92 7
ULK1 83 3
ULK2 100 10
TGFBR1 82 13
Src 88 10
Lck 87 5
CSK 109 16
YES1 93 2
ABL 95 8
BTK 104 2
JAK2 73 2
SYK 96 4
ZAP70 96 3
TIE2 77 1
BRK 84 3
EPH-A2 103 0
EPH-A4 100 2
EPH-B1 97 4
EPH-B2 100 14
EPH-B3 93 2
EPH-B4 99 9
FGF-R1 94 13
HER4 105 2
IGF-1R 76 3
IR 87 19
IRR 96 0
TrkA 85 5
DDR2 85 20
VEGFR1 97 7
PDGFRA 89 6
PINK 92 5

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