Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
BX-912 C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 63 3
MKK2 57 5
MKK6 74 12
ERK1 88 3
ERK2 89 3
ERK5 83 2
JNK1 102 13
JNK2 93 1
JNK3 101 4
p38 alpha MAPK 96 17
p38 beta MAPK 92 3
p38 gamma MAPK 86 5
p38 delta MAPK 99 33
ERK8 42 5
RSK1 82 16
RSK2 62 11
PDK1 43 9
PKB alpha 87 1
PKB beta 94 10
SGK1 87 1
S6K1 80 2
PKA 69 6
ROCK 2 102 5
PRK2 68 3
PKC alpha 82 6
PKC gamma 110 3
PKC zeta 109 21
PKD1 81 1
STK33 76 4
MSK1 100 8
MNK1 97 17
MNK2 95 4
MAPKAP-K2 97 9
MAPKAP-K3 106 6
PRAK 112 8
CAMKK beta 65 2
CAMK1 93 11
SmMLCK 88 13
PHK 101 6
DAPK1 100 2
CHK1 50 3
CHK2 67 5
GSK3 beta 87 15
CDK2-Cyclin A 50 1
CDK9-Cyclin T1 86 6
PLK1 106 10
Aurora A 62 9
Aurora B 7 2
TLK1 95 10
LKB1 79 4
AMPK (hum) 28 1
MARK1 41 4
MARK2 42 5
MARK3 18 1
MARK4 32 5
BRSK1 44 1
BRSK2 50 6
MELK 72 8
NUAK1 2 0
SIK2 9 0
SIK3 42 2
TSSK1 69 11
CK1 gamma 2 99 14
CK1 delta 92 3
CK2 103 11
TTBK1 94 3
TTBK2 109 25
DYRK1A 84 8
DYRK2 101 5
DYRK3 99 5
NEK2a 101 13
NEK6 101 1
IKK beta 111 6
IKK epsilon 62 1
TBK1 45 5
PIM1 105 1
PIM2 105 4
PIM3 113 3
SRPK1 96 3
EF2K 91 24
EIF2AK3 97 1
HIPK1 87 14
HIPK2 92 1
HIPK3 94 4
CLK2 82 1
PAK2 99 7
PAK4 93 3
PAK5 89 9
PAK6 104 21
MST2 56 0
MST3 79 5
MST4 77 4
GCK 39 7
MAP4K3 75 6
MAP4K5 70 2
MINK1 73 7
MEKK1 94 6
MLK1 16 0
MLK3 11 1
TESK1 102 13
TAO1 81 2
ASK1 96 2
TAK1 49 1
IRAK1 100 1
IRAK4 42 1
RIPK2 68 4
OSR1 100 12
TTK 95 10
MPSK1 121 1
WNK1 112 6
ULK1 48 6
ULK2 91 9
TGFBR1 87 6
Src 89 3
Lck 95 16
CSK 93 9
YES1 82 7
ABL 87 7
BTK 91 7
JAK2 27 0
SYK 74 16
ZAP70 100 3
TIE2 85 2
BRK 89 0
EPH-A2 100 5
EPH-A4 98 14
EPH-B1 109 1
EPH-B2 93 11
EPH-B3 104 5
EPH-B4 104 4
FGF-R1 49 6
HER4 94 9
IGF-1R 80 3
IR 82 25
IRR 102 12
TrkA 40 4
DDR2 89 5
VEGFR1 10 0
PDGFRA 65 1
PINK 84 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 20 3
MKK2 20 3
MKK6 56 7
ERK1 67 5
ERK2 63 1
ERK5 63 8
JNK1 74 7
JNK2 59 1
JNK3 76 0
p38 alpha MAPK 91 3
p38 beta MAPK 85 3
p38 gamma MAPK 84 3
p38 delta MAPK 72 4
ERK8 8 2
RSK1 42 0
RSK2 45 4
PDK1 8 0
PKB alpha 81 3
PKB beta 91 11
SGK1 60 2
S6K1 52 4
PKA 30 1
ROCK 2 75 2
PRK2 32 4
PKC alpha 73 20
PKC gamma 86 12
PKC zeta 118 6
PKD1 37 1
STK33 33 6
MSK1 74 11
MNK1 79 2
MNK2 45 2
MAPKAP-K2 103 13
MAPKAP-K3 98 4
PRAK 101 8
CAMKK beta 18 0
CAMK1 89 9
SmMLCK 80 5
PHK 48 0
DAPK1 76 9
CHK1 14 0
CHK2 18 2
GSK3 beta 81 0
CDK2-Cyclin A 12 4
CDK9-Cyclin T1 60 7
PLK1 77 17
Aurora A 14 3
Aurora B 2 1
TLK1 91 0
LKB1 49 6
AMPK (hum) 5 1
MARK1 10 0
MARK2 12 2
MARK3 4 1
MARK4 7 1
BRSK1 12 1
BRSK2 13 0
MELK 30 3
NUAK1 1 0
SIK2 2 1
SIK3 11 1
TSSK1 45 5
CK1 gamma 2 84 4
CK1 delta 87 3
CK2 80 4
TTBK1 101 5
TTBK2 89 6
DYRK1A 75 8
DYRK2 79 1
DYRK3 83 3
NEK2a 82 13
NEK6 95 17
IKK beta 94 3
IKK epsilon 24 1
TBK1 12 3
PIM1 105 5
PIM2 105 15
PIM3 104 3
SRPK1 96 13
EF2K 101 30
EIF2AK3 94 5
HIPK1 63 7
HIPK2 90 9
HIPK3 81 1
CLK2 26 0
PAK2 87 20
PAK4 54 4
PAK5 73 4
PAK6 87 10
MST2 31 2
MST3 49 3
MST4 48 3
GCK 11 3
MAP4K3 18 2
MAP4K5 35 2
MINK1 52 10
MEKK1 97 1
MLK1 2 0
MLK3 11 5
TESK1 93 5
TAO1 46 8
ASK1 46 1
TAK1 15 2
IRAK1 48 5
IRAK4 10 1
RIPK2 47 2
OSR1 89 4
TTK 76 5
MPSK1 105 2
WNK1 104 4
ULK1 15 1
ULK2 42 4
TGFBR1 92 6
Src 53 5
Lck 43 3
CSK 88 9
YES1 42 8
ABL 35 0
BTK 40 7
JAK2 10 2
SYK 21 4
ZAP70 88 2
TIE2 58 13
BRK 39 2
EPH-A2 87 9
EPH-A4 86 3
EPH-B1 110 5
EPH-B2 79 4
EPH-B3 99 6
EPH-B4 104 10
FGF-R1 9 2
HER4 69 21
IGF-1R 45 4
IR 34 7
IRR 73 6
TrkA 17 5
DDR2 69 4
VEGFR1 2 0
PDGFRA 29 5
PINK 88 4

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