Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PRT062607 C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387 Axon Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 80 5
MKK2 81 11
MKK6 85 3
ERK1 76 3
ERK2 96 3
ERK5 71 3
JNK1 85 11
JNK2 86 4
JNK3 104 0
p38 alpha MAPK 98 8
p38 beta MAPK 98 16
p38 gamma MAPK 79 1
p38 delta MAPK 103 6
ERK8 84 4
RSK1 91 3
RSK2 83 17
PDK1 92 11
PKB alpha 94 6
PKB beta 97 8
SGK1 90 2
S6K1 87 14
PKA 82 14
ROCK 2 85 9
PRK2 78 3
PKC alpha 79 10
PKC gamma 95 0
PKC zeta 114 7
PKD1 88 7
STK33 93 6
MSK1 99 6
MNK1 101 4
MNK2 102 3
MAPKAP-K2 105 1
MAPKAP-K3 107 1
PRAK 101 5
CAMKK beta 101 3
CAMK1 77 2
SmMLCK 79 8
PHK 112 21
DAPK1 83 11
CHK1 92 22
CHK2 94 3
GSK3 beta 99 8
CDK2-Cyclin A 53 4
CDK9-Cyclin T1 86 7
PLK1 88 9
Aurora A 98 6
Aurora B 71 16
TLK1 99 9
LKB1 64 8
AMPK (hum) 92 11
MARK1 101 12
MARK2 99 4
MARK3 71 0
MARK4 97 16
BRSK1 109 23
BRSK2 107 5
MELK 84 3
NUAK1 100 5
SIK2 66 2
SIK3 87 9
TSSK1 84 4
CK1 gamma 2 99 20
CK1 delta 54 2
CK2 96 0
TTBK1 101 0
TTBK2 90 11
DYRK1A 89 10
DYRK2 109 5
DYRK3 84 5
NEK2a 104 12
NEK6 96 4
IKK beta 84 4
IKK epsilon 88 10
TBK1 96 7
PIM1 66 5
PIM2 101 17
PIM3 84 2
SRPK1 110 35
EF2K 101 23
EIF2AK3 91 4
HIPK1 93 6
HIPK2 104 23
HIPK3 93 8
CLK2 74 1
PAK2 100 12
PAK4 32 4
PAK5 33 4
PAK6 72 15
MST2 65 5
MST3 99 9
MST4 84 6
GCK 49 7
MAP4K3 89 8
MAP4K5 94 14
MINK1 78 1
MEKK1 98 2
MLK1 51 9
MLK3 29 4
TESK1 101 2
TAO1 98 13
ASK1 106 18
TAK1 83 5
IRAK1 87 3
IRAK4 84 10
RIPK2 93 5
OSR1 94 1
TTK 92 4
MPSK1 110 1
WNK1 106 7
ULK1 91 0
ULK2 109 12
TGFBR1 87 2
Src 51 6
Lck 88 10
CSK 76 5
YES1 41 12
ABL 107 5
BTK 57 1
JAK2 75 4
SYK 5 2
ZAP70 89 8
TIE2 99 8
BRK 82 5
EPH-A2 107 1
EPH-A4 83 9
EPH-B1 108 1
EPH-B2 98 15
EPH-B3 96 5
EPH-B4 107 6
FGF-R1 89 16
HER4 86 8
IGF-1R 47 8
IR 75 13
IRR 78 5
TrkA 38 4
DDR2 102 7
VEGFR1 93 3
PDGFRA 95 13
PINK 85 2
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 5 1
MKK2 4 0
MKK6 31 0
ERK1 15 0
ERK2 12 1
ERK5 13 1
JNK1 42 8
JNK2 47 7
JNK3 47 0
p38 alpha MAPK 83 7
p38 beta MAPK 77 13
p38 gamma MAPK 39 2
p38 delta MAPK 47 0
ERK8 5 2
RSK1 28 0
RSK2 30 6
PDK1 53 8
PKB alpha 49 1
PKB beta 78 13
SGK1 82 0
S6K1 40 4
PKA 57 6
ROCK 2 22 1
PRK2 10 2
PKC alpha 14 5
PKC gamma 26 3
PKC zeta 86 4
PKD1 11 2
STK33 17 0
MSK1 41 4
MNK1 61 56
MNK2 31 5
MAPKAP-K2 91 8
MAPKAP-K3 88 6
PRAK 65 1
CAMKK beta 21 1
CAMK1 3 0
SmMLCK 7 1
PHK 19 1
DAPK1 5 1
CHK1 11 2
CHK2 9 0
GSK3 beta 41 11
CDK2-Cyclin A 20 1
CDK9-Cyclin T1 24 1
PLK1 69 11
Aurora A 102 3
Aurora B 60 10
TLK1 67 4
LKB1 31 7
AMPK (hum) 22 2
MARK1 34 1
MARK2 26 5
MARK3 6 1
MARK4 26 2
BRSK1 66 2
BRSK2 73 8
MELK 22 0
NUAK1 9 2
SIK2 4 1
SIK3 19 3
TSSK1 14 1
CK1 gamma 2 30 5
CK1 delta 2 0
CK2 32 4
TTBK1 62 3
TTBK2 49 15
DYRK1A 42 4
DYRK2 79 3
DYRK3 6 0
NEK2a 45 5
NEK6 88 2
IKK beta 85 7
IKK epsilon 30 1
TBK1 75 5
PIM1 2 0
PIM2 55 8
PIM3 3 0
SRPK1 73 6
EF2K 55 9
EIF2AK3 71 4
HIPK1 52 6
HIPK2 54 5
HIPK3 78 8
CLK2 3 0
PAK2 47 8
PAK4 11 1
PAK5 2 0
PAK6 4 1
MST2 9 2
MST3 14 4
MST4 26 2
GCK 3 1
MAP4K3 4 1
MAP4K5 15 2
MINK1 8 1
MEKK1 94 1
MLK1 2 2
MLK3 5 1
TESK1 14 0
TAO1 13 1
ASK1 80 11
TAK1 8 1
IRAK1 15 2
IRAK4 7 3
RIPK2 21 0
OSR1 37 2
TTK 47 1
MPSK1 108 1
WNK1 61 2
ULK1 17 0
ULK2 23 3
TGFBR1 88 9
Src 3 1
Lck 8 1
CSK 48 1
YES1 3 0
ABL 51 2
BTK 9 0
JAK2 12 1
SYK 1 0
ZAP70 10 0
TIE2 72 13
BRK 4 0
EPH-A2 25 3
EPH-A4 6 0
EPH-B1 45 2
EPH-B2 4 1
EPH-B3 58 1
EPH-B4 40 0
FGF-R1 66 18
HER4 12 2
IGF-1R 1 1
IR 3 1
IRR 11 1
TrkA 6 3
DDR2 27 6
VEGFR1 51 4
PDGFRA 36 1
PINK 11 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 52 20
MKK2 48 16
MKK6 62 1
ERK1 53 4
ERK2 48 10
ERK5 29 2
JNK1 88 20
JNK2 85 1
JNK3 80 1
p38 alpha MAPK 94 15
p38 beta MAPK 103 10
p38 gamma MAPK 69 1
p38 delta MAPK 88 7
ERK8 42 4
RSK1 73 7
RSK2 63 7
PDK1 85 13
PKB alpha 87 11
PKB beta 92 7
SGK1 85 1
S6K1 77 3
PKA 82 3
ROCK 2 60 5
PRK2 38 5
PKC alpha 45 7
PKC gamma 71 9
PKC zeta 110 4
PKD1 44 6
STK33 49 6
MSK1 75 5
MNK1 72 7
MNK2 80 6
MAPKAP-K2 99 1
MAPKAP-K3 105 14
PRAK 100 9
CAMKK beta 67 4
CAMK1 21 0
SmMLCK 35 1
PHK 84 12
DAPK1 26 1
CHK1 40 12
CHK2 38 1
GSK3 beta 76 15
CDK2-Cyclin A 28 0
CDK9-Cyclin T1 69 5
PLK1 81 12
Aurora A 105 15
Aurora B 71 6
TLK1 97 3
LKB1 35 7
AMPK (hum) 83 16
MARK1 66 2
MARK2 71 5
MARK3 31 2
MARK4 74 8
BRSK1 96 8
BRSK2 97 10
MELK 73 1
NUAK1 48 6
SIK2 19 3
SIK3 67 8
TSSK1 34 2
CK1 gamma 2 74 4
CK1 delta 13 2
CK2 78 1
TTBK1 92 4
TTBK2 98 5
DYRK1A 88 2
DYRK2 106 9
DYRK3 37 2
NEK2a 101 22
NEK6 101 18
IKK beta 97 1
IKK epsilon 71 3
TBK1 97 2
PIM1 13 0
PIM2 97 16
PIM3 27 1
SRPK1 95 6
EF2K 84 7
EIF2AK3 86 2
HIPK1 75 5
HIPK2 87 0
HIPK3 100 19
CLK2 32 2
PAK2 86 7
PAK4 12 2
PAK5 7 0
PAK6 24 4
MST2 21 5
MST3 68 6
MST4 65 3
GCK 14 4
MAP4K3 39 12
MAP4K5 50 5
MINK1 53 8
MEKK1 89 0
MLK1 6 1
MLK3 9 1
TESK1 55 5
TAO1 64 16
ASK1 95 8
TAK1 31 1
IRAK1 52 2
IRAK4 24 2
RIPK2 57 4
OSR1 79 1
TTK 81 3
MPSK1 130 3
WNK1 98 2
ULK1 54 2
ULK2 66 3
TGFBR1 85 10
Src 13 3
Lck 36 1
CSK 88 9
YES1 10 1
ABL 90 11
BTK 17 4
JAK2 24 2
SYK 2 1
ZAP70 28 2
TIE2 94 17
BRK 25 3
EPH-A2 81 3
EPH-A4 27 0
EPH-B1 96 11
EPH-B2 54 1
EPH-B3 105 1
EPH-B4 94 13
FGF-R1 94 20
HER4 52 9
IGF-1R 4 1
IR 27 7
IRR 40 4
TrkA 16 3
DDR2 73 0
VEGFR1 79 2
PDGFRA 72 3
PINK 44 2

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