Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
KU55933 C21H17NO3S2 395.49 ATM Li Y. (2010) Mol. Cancer Ther. 2010 Jan. 9(1) 113-25 Tocris Bioscience Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 90 7
MKK2 77 17
MKK6 75 9
ERK1 99 12
ERK2 88 1
ERK5 79 13
JNK1 94 14
JNK2 86 14
JNK3 104 5
p38 alpha MAPK 92 10
p38 beta MAPK 87 18
p38 gamma MAPK 77 8
p38 delta MAPK 83 1
ERK8 63 2
RSK1 92 1
RSK2 79 8
PDK1 93 10
PKB alpha 86 1
PKB beta 89 3
SGK1 96 6
S6K1 85 2
PKA 94 0
ROCK 2 86 3
PRK2 85 0
PKC alpha 103 11
PKC gamma 103 9
PKC zeta 96 3
PKD1 88 2
STK33 87 6
MSK1 98 8
MNK1 83 4
MNK2 102 4
MAPKAP-K2 95 2
MAPKAP-K3 98 2
PRAK 94 2
CAMKK beta 93 6
CAMK1 91 3
SmMLCK 82 8
PHK 103 12
DAPK1 107 22
CHK1 82 10
CHK2 101 8
GSK3 beta 93 3
CDK2-Cyclin A 94 9
CDK9-Cyclin T1 88 8
PLK1 89 10
Aurora A 95 7
Aurora B 69 6
TLK1 98 5
LKB1 79 3
AMPK (hum) 100 7
MARK1 86 4
MARK2 92 9
MARK3 68 10
MARK4 94 10
BRSK1 94 10
BRSK2 94 10
MELK 89 12
NUAK1 99 9
SIK2 83 2
SIK3 76 4
TSSK1 90 8
CK1 gamma 2 62 3
CK1 delta 79 1
CK2 99 1
TTBK1 86 2
TTBK2 80 13
DYRK1A 57 0
DYRK2 96 4
DYRK3 108 11
NEK2a 101 16
NEK6 87 4
IKK beta 102 8
IKK epsilon 77 3
TBK1 81 0
PIM1 86 5
PIM2 97 3
PIM3 73 0
SRPK1 84 8
EF2K 90 2
EIF2AK3 99 6
HIPK1 78 2
HIPK2 90 9
HIPK3 86 4
CLK2 94 13
PAK2 93 8
PAK4 100 24
PAK5 87 4
PAK6 97 8
MST2 69 2
MST3 63 6
MST4 76 4
GCK 74 15
MAP4K3 83 14
MAP4K5 74 3
MINK1 77 1
MEKK1 95 9
MLK1 78 10
MLK3 79 13
TESK1 82 1
TAO1 79 4
ASK1 100 17
TAK1 83 3
IRAK1 95 8
IRAK4 80 1
RIPK2 63 2
OSR1 99 2
TTK 89 3
MPSK1 101 7
WNK1 93 9
ULK1 74 10
ULK2 99 13
TGFBR1 80 9
Src 85 0
Lck 87 2
CSK 119 29
YES1 93 3
ABL 101 6
BTK 84 6
JAK2 96 6
SYK 93 2
ZAP70 92 3
TIE2 88 9
BRK 81 3
EPH-A2 107 10
EPH-A4 101 12
EPH-B1 102 1
EPH-B2 88 2
EPH-B3 86 9
EPH-B4 98 9
FGF-R1 85 10
HER4 92 3
IGF-1R 84 2
IR 91 21
IRR 107 5
TrkA 90 9
DDR2 95 3
VEGFR1 83 9
PDGFRA 102 13
PINK 78 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 71 15
MKK2 70 2
MKK6 78 1
ERK1 94 3
ERK2 78 2
ERK5 88 1
JNK1 83 0
JNK2 86 0
JNK3 108 25
p38 alpha MAPK 87 2
p38 beta MAPK 75 6
p38 gamma MAPK 67 14
p38 delta MAPK 76 4
ERK8 75 2
RSK1 88 3
RSK2 74 6
PDK1 93 8
PKB alpha 73 2
PKB beta 87 5
SGK1 94 2
S6K1 82 10
PKA 93 2
ROCK 2 82 5
PRK2 74 6
PKC alpha 89 11
PKC gamma 95 4
PKC zeta 98 1
PKD1 95 4
STK33 95 5
MSK1 97 8
MNK1 99 4
MNK2 94 2
MAPKAP-K2 91 2
MAPKAP-K3 91 6
PRAK 94 6
CAMKK beta 82 6
CAMK1 90 4
SmMLCK 84 1
PHK 110 21
DAPK1 98 2
CHK1 74 0
CHK2 97 0
GSK3 beta 94 4
CDK2-Cyclin A 84 7
CDK9-Cyclin T1 88 2
PLK1 87 13
Aurora A 99 10
Aurora B 64 14
TLK1 88 1
LKB1 82 9
AMPK (hum) 65 8
MARK1 69 3
MARK2 76 3
MARK3 62 10
MARK4 84 3
BRSK1 85 1
BRSK2 104 4
MELK 67 2
NUAK1 99 10
SIK2 67 3
SIK3 72 5
TSSK1 72 2
CK1 gamma 2 93 6
CK1 delta 81 2
CK2 96 1
TTBK1 87 2
TTBK2 94 9
DYRK1A 76 6
DYRK2 89 1
DYRK3 100 2
NEK2a 100 1
NEK6 80 8
IKK beta 102 4
IKK epsilon 73 6
TBK1 92 13
PIM1 93 3
PIM2 108 14
PIM3 103 9
SRPK1 87 8
EF2K 97 13
EIF2AK3 98 1
HIPK1 79 7
HIPK2 84 11
HIPK3 82 4
CLK2 93 1
PAK2 86 3
PAK4 119 17
PAK5 83 2
PAK6 88 6
MST2 64 5
MST3 68 8
MST4 79 0
GCK 85 16
MAP4K3 82 5
MAP4K5 73 6
MINK1 71 4
MEKK1 90 13
MLK1 81 11
MLK3 68 2
TESK1 85 2
TAO1 79 9
ASK1 108 17
TAK1 68 4
IRAK1 87 7
IRAK4 80 1
RIPK2 70 2
OSR1 89 5
TTK 86 4
MPSK1 90 2
WNK1 88 6
ULK1 69 3
ULK2 84 5
TGFBR1 75 1
Src 85 15
Lck 86 4
CSK 112 17
YES1 85 5
ABL 101 5
BTK 90 2
JAK2 83 12
SYK 89 1
ZAP70 95 5
TIE2 85 16
BRK 91 3
EPH-A2 104 12
EPH-A4 88 12
EPH-B1 98 4
EPH-B2 85 1
EPH-B3 91 5
EPH-B4 97 17
FGF-R1 91 14
HER4 96 6
IGF-1R 79 6
IR 77 12
IRR 98 7
TrkA 94 2
DDR2 89 3
VEGFR1 78 8
PDGFRA 106 31
PINK 81 6

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