Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK2606414 C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207 Merck Millipore Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
MARK3 1 0
RSK1 1 0
EIF2AK3 1 0
AMPK (hum) 1 0
MARK2 2 0
IKK epsilon 2 1
SIK2 2 0
TSSK1 2 0
MAP4K3 2 0
RSK2 2 1
PDK1 2 0
MARK4 3 1
TrkA 3 2
MST2 3 0
MAP4K5 3 1
MLK1 3 0
JAK2 4 2
SIK3 4 0
MKK1 4 0
MARK1 5 0
PDGFRA 5 0
GCK 5 0
MLK3 5 1
VEGFR1 6 1
Aurora B 6 0
MKK2 6 1
PRK2 7 1
SYK 7 1
CHK1 8 1
PKR 9 0
S6K1 10 2
NUAK1 10 2
BRK 10 3
TIE2 11 2
MELK 12 2
TBK1 13 4
CDK2-Cyclin A 13 1
MINK1 15 3
TAO1 16 0
ULK2 16 1
BRSK2 21 7
PAK4 22 1
Lck 22 3
Src 24 1
PKA 25 1
PAK5 26 4
ROCK 2 28 5
IRAK4 29 3
DDR2 30 6
TLK1 32 3
DAPK1 33 0
p38 delta MAPK 35 4
CLK2 37 1
PKD1 37 4
MSK1 38 2
TAK1 40 6
TESK1 42 0
STK33 42 5
YES1 45 9
CHK2 49 6
PKC alpha 50 8
CAMK1 51 2
ABL 51 2
MST4 52 13
Aurora A 52 12
PAK6 53 7
FGF-R1 53 3
OSR1 54 1
EPH-B3 54 4
PKB alpha 54 0
DYRK1A 55 5
BTK 55 5
CSK 56 7
NEK2a 56 1
TTK 56 12
HIPK2 56 16
PKC gamma 57 2
EPH-B1 57 9
PIM1 58 2
PHK 59 12
ULK1 59 1
ERK8 61 6
PKB beta 61 2
IR 62 17
SGK1 65 0
EPH-A4 65 8
EPH-A2 69 11
MKK6 70 4
ZAP70 71 5
EPH-B4 71 3
ERK5 72 3
CDK9-Cyclin T1 72 3
IRR 74 0
RIPK2 75 6
MNK2 75 4
BRSK1 76 9
WNK1 77 16
EPH-B2 77 1
IGF-1R 78 7
IRAK1 79 8
MAPKAP-K2 81 0
DYRK3 82 9
HIPK1 83 4
ASK1 84 17
NEK6 84 4
MST3 84 4
DYRK2 86 1
JNK2 86 4
p38 beta MAPK 88 2
PRAK 88 2
CAMKK beta 89 3
PKC zeta 89 0
p38 gamma MAPK 89 27
CK1 delta 90 1
SmMLCK 91 9
JNK3 91 6
GSK3 beta 91 10
PIM2 91 5
PAK2 94 6
MEKK1 95 4
TGFBR1 97 1
HER4 98 12
PIM3 100 10
p38 alpha MAPK 101 15
MNK1 101 6
HIPK3 102 15
JNK1 102 2
PINK 102 12
CK1 gamma 2 102 15
ERK1 103 4
IKK beta 104 19
MPSK1 105 13
PLK1 106 12
SRPK1 106 1
LKB1 106 6
MAPKAP-K3 107 3
TTBK1 107 7
EF2K 108 26
ERK2 113 1
CK2 113 1
TTBK2 118 2
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
EIF2AK3 3 1
IKK epsilon 15 6
TSSK1 18 1
PDGFRA 19 2
PKR 20 1
MLK1 23 2
MLK3 31 6
Aurora B 34 1
TrkA 37 5
BRK 42 9
TIE2 51 10
SIK2 52 3
MAP4K5 52 12
MKK2 59 3
VEGFR1 61 5
MAP4K3 63 3
JAK2 64 6
MARK2 65 3
SIK3 66 13
GCK 66 4
MST2 70 7
MELK 72 5
RSK2 72 4
MARK1 72 11
TESK1 73 12
MARK4 73 13
STK33 75 3
AMPK (hum) 75 0
CLK2 76 4
PKC gamma 77 0
ULK2 77 9
Lck 78 0
RSK1 79 1
BRSK1 81 3
MKK1 82 1
PDK1 82 14
Src 82 30
IR 82 1
PRAK 83 4
IGF-1R 83 9
DDR2 85 5
TBK1 85 8
CDK2-Cyclin A 85 7
p38 delta MAPK 85 5
IRR 85 4
EPH-A2 86 4
ABL 86 11
ROCK 2 86 9
PRK2 87 6
CHK1 87 19
MEKK1 87 5
FGF-R1 87 9
CSK 87 13
PAK4 87 3
BRSK2 88 2
CHK2 88 10
MST3 88 9
MPSK1 89 16
NEK2a 89 2
ERK8 90 1
EPH-B1 90 0
TGFBR1 90 18
ERK1 90 11
CAMK1 91 6
p38 alpha MAPK 92 16
TLK1 92 7
YES1 92 1
ZAP70 93 2
EPH-B3 93 5
PKB alpha 93 10
HIPK2 93 17
JNK3 94 5
PIM1 95 5
DYRK1A 95 3
PKC zeta 96 1
MNK1 96 11
LKB1 96 16
EPH-B4 96 9
DAPK1 97 11
PAK5 97 1
p38 beta MAPK 97 4
EF2K 97 8
MAPKAP-K2 97 18
MKK6 97 7
BTK 97 9
MNK2 98 12
TTBK1 98 14
PKA 98 12
ASK1 98 9
CDK9-Cyclin T1 99 11
SRPK1 99 11
MINK1 99 11
CAMKK beta 99 8
SmMLCK 99 7
PAK2 99 1
JNK2 100 10
PLK1 100 18
HIPK1 100 1
RIPK2 101 2
MSK1 101 11
MARK3 101 9
JNK1 101 1
GSK3 beta 102 2
DYRK2 102 10
TAO1 102 11
TAK1 102 3
NEK6 103 5
OSR1 103 18
TTK 103 8
PINK 103 4
PIM2 103 7
CK2 104 2
PKB beta 104 3
S6K1 104 7
PHK 104 1
PKC alpha 105 13
SYK 105 14
NUAK1 105 3
PKD1 105 4
Aurora A 105 10
SGK1 105 1
IRAK1 106 1
WNK1 106 3
HER4 106 4
ERK5 106 11
DYRK3 106 5
p38 gamma MAPK 107 22
PIM3 107 6
HIPK3 107 4
ERK2 107 17
MST4 108 7
CK1 delta 108 2
EPH-B2 108 1
IRAK4 109 6
ULK1 109 15
IKK beta 110 17
MAPKAP-K3 111 2
PAK6 112 1
EPH-A4 113 3
TTBK2 120 7
CK1 gamma 2 129 3

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