Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GSK2606414 C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207 Merck Millipore Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 4 0
MKK2 6 1
MKK6 70 4
ERK1 103 4
ERK2 113 1
ERK5 72 3
JNK1 102 2
JNK2 86 4
JNK3 91 6
p38 alpha MAPK 101 15
p38 beta MAPK 88 2
p38 gamma MAPK 89 27
p38 delta MAPK 35 4
ERK8 61 6
RSK1 1 0
RSK2 2 1
PDK1 2 0
PKB alpha 54 0
PKB beta 61 2
SGK1 65 0
S6K1 10 2
PKA 25 1
ROCK 2 28 5
PRK2 7 1
PKC alpha 50 8
PKC gamma 57 2
PKC zeta 89 0
PKD1 37 4
STK33 42 5
MSK1 38 2
MNK1 101 6
MNK2 75 4
MAPKAP-K2 81 0
MAPKAP-K3 107 3
PRAK 88 2
CAMKK beta 89 3
CAMK1 51 2
SmMLCK 91 9
PHK 59 12
DAPK1 33 0
CHK1 8 1
CHK2 49 6
GSK3 beta 91 10
CDK2-Cyclin A 13 1
CDK9-Cyclin T1 72 3
PLK1 106 12
Aurora A 52 12
Aurora B 6 0
TLK1 32 3
LKB1 106 6
AMPK (hum) 1 0
MARK1 5 0
MARK2 2 0
MARK3 1 0
MARK4 3 1
BRSK1 76 9
BRSK2 21 7
MELK 12 2
NUAK1 10 2
SIK2 2 0
SIK3 4 0
TSSK1 2 0
CK1 gamma 2 102 15
CK1 delta 90 1
CK2 113 1
TTBK1 107 7
TTBK2 118 2
DYRK1A 55 5
DYRK2 86 1
DYRK3 82 9
NEK2a 56 1
NEK6 84 4
IKK beta 104 19
IKK epsilon 2 1
TBK1 13 4
PIM1 58 2
PIM2 91 5
PIM3 100 10
SRPK1 106 1
EF2K 108 26
EIF2AK3 1 0
HIPK1 83 4
HIPK2 56 16
HIPK3 102 15
CLK2 37 1
PAK2 94 6
PAK4 22 1
PAK5 26 4
PAK6 53 7
MST2 3 0
MST3 84 4
MST4 52 13
GCK 5 0
MAP4K3 2 0
MAP4K5 3 1
MINK1 15 3
MEKK1 95 4
MLK1 3 0
MLK3 5 1
TESK1 42 0
TAO1 16 0
ASK1 84 17
TAK1 40 6
IRAK1 79 8
IRAK4 29 3
RIPK2 75 6
OSR1 54 1
TTK 56 12
MPSK1 105 13
WNK1 77 16
ULK1 59 1
ULK2 16 1
TGFBR1 97 1
Src 24 1
Lck 22 3
CSK 56 7
YES1 45 9
ABL 51 2
BTK 55 5
JAK2 4 2
SYK 7 1
ZAP70 71 5
TIE2 11 2
BRK 10 3
EPH-A2 69 11
EPH-A4 65 8
EPH-B1 57 9
EPH-B2 77 1
EPH-B3 54 4
EPH-B4 71 3
FGF-R1 53 3
HER4 98 12
IGF-1R 78 7
IR 62 17
IRR 74 0
TrkA 3 2
DDR2 30 6
VEGFR1 6 1
PDGFRA 5 0
PINK 102 12
PKR 9 0
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 1
MKK2 59 3
MKK6 97 7
ERK1 90 11
ERK2 107 17
ERK5 106 11
JNK1 101 1
JNK2 100 10
JNK3 94 5
p38 alpha MAPK 92 16
p38 beta MAPK 97 4
p38 gamma MAPK 107 22
p38 delta MAPK 85 5
ERK8 90 1
RSK1 79 1
RSK2 72 4
PDK1 82 14
PKB alpha 93 10
PKB beta 104 3
SGK1 105 1
S6K1 104 7
PKA 98 12
ROCK 2 86 9
PRK2 87 6
PKC alpha 105 13
PKC gamma 77 0
PKC zeta 96 1
PKD1 105 4
STK33 75 3
MSK1 101 11
MNK1 96 11
MNK2 98 12
MAPKAP-K2 97 18
MAPKAP-K3 111 2
PRAK 83 4
CAMKK beta 99 8
CAMK1 91 6
SmMLCK 99 7
PHK 104 1
DAPK1 97 11
CHK1 87 19
CHK2 88 10
GSK3 beta 102 2
CDK2-Cyclin A 85 7
CDK9-Cyclin T1 99 11
PLK1 100 18
Aurora A 105 10
Aurora B 34 1
TLK1 92 7
LKB1 96 16
AMPK (hum) 75 0
MARK1 72 11
MARK2 65 3
MARK3 101 9
MARK4 73 13
BRSK1 81 3
BRSK2 88 2
MELK 72 5
NUAK1 105 3
SIK2 52 3
SIK3 66 13
TSSK1 18 1
CK1 gamma 2 129 3
CK1 delta 108 2
CK2 104 2
TTBK1 98 14
TTBK2 120 7
DYRK1A 95 3
DYRK2 102 10
DYRK3 106 5
NEK2a 89 2
NEK6 103 5
IKK beta 110 17
IKK epsilon 15 6
TBK1 85 8
PIM1 95 5
PIM2 103 7
PIM3 107 6
SRPK1 99 11
EF2K 97 8
EIF2AK3 3 1
HIPK1 100 1
HIPK2 93 17
HIPK3 107 4
CLK2 76 4
PAK2 99 1
PAK4 87 3
PAK5 97 1
PAK6 112 1
MST2 70 7
MST3 88 9
MST4 108 7
GCK 66 4
MAP4K3 63 3
MAP4K5 52 12
MINK1 99 11
MEKK1 87 5
MLK1 23 2
MLK3 31 6
TESK1 73 12
TAO1 102 11
ASK1 98 9
TAK1 102 3
IRAK1 106 1
IRAK4 109 6
RIPK2 101 2
OSR1 103 18
TTK 103 8
MPSK1 89 16
WNK1 106 3
ULK1 109 15
ULK2 77 9
TGFBR1 90 18
Src 82 30
Lck 78 0
CSK 87 13
YES1 92 1
ABL 86 11
BTK 97 9
JAK2 64 6
SYK 105 14
ZAP70 93 2
TIE2 51 10
BRK 42 9
EPH-A2 86 4
EPH-A4 113 3
EPH-B1 90 0
EPH-B2 108 1
EPH-B3 93 5
EPH-B4 96 9
FGF-R1 87 9
HER4 106 4
IGF-1R 83 9
IR 82 1
IRR 85 4
TrkA 37 5
DDR2 85 5
VEGFR1 61 5
PDGFRA 19 2
PINK 103 4
PKR 20 1

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