Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Fostamatinib C23H26FN6O9P 580.46 Seleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
JAK2 -5 12
EPH-B1 3 0
MLK1 4 0
MLK3 4 0
PAK4 6 0
EPH-B2 6 1
IGF-1R 7 1
ZAP70 7 1
Lck 8 2
EPH-A2 9 2
IR 11 0
DDR2 14 5
BTK 15 0
CSK 16 2
ULK1 16 0
YES1 17 0
IRR 18 0
IKK epsilon 19 2
NUAK1 19 0
FGF-R1 22 1
IRAK1 24 3
JNK3 24 2
HER4 25 3
JNK2 26 1
S6K1 27 1
PAK5 27 8
AMPK (hum) 28 0
SGK1 30 3
ULK2 30 2
EPH-B3 31 6
ERK8 36 0
LKB1 37 2
SIK2 37 7
CLK2 39 0
TSSK1 43 0
Aurora A 45 62
TESK1 46 6
Aurora B 46 55
EPH-B4 48 58
SYK 54 49
PLK1 55 4
EIF2AK3 55 4
NEK2a 58 1
PAK2 59 6
MAP4K3 60 0
PKA 61 0
IRAK4 62 4
RSK1 62 17
CK2 62 5
TAK1 63 13
PAK6 64 6
MST2 64 15
CAMKK beta 66 20
MPSK1 66 8
TIE2 68 4
PRK2 69 8
JNK1 70 44
p38 delta MAPK 71 6
MSK1 71 7
MNK2 71 4
SIK3 72 9
PDGFRA 73 66
STK33 73 55
DYRK2 74 7
TAO1 74 8
CHK2 74 33
TTK 74 4
PDK1 74 55
MAP4K5 75 4
MARK4 76 9
GSK3 beta 76 0
IKK beta 77 10
PKC alpha 78 2
RSK2 78 35
MST4 79 8
DYRK1A 80 2
CHK1 81 3
RIPK2 82 4
MKK6 83 4
ERK5 84 6
CDK2-Cyclin A 84 1
PIM3 84 3
MELK 85 14
Src 86 7
ROCK 2 86 4
PHK 86 6
PKC gamma 86 5
GCK 86 54
MARK3 87 43
DYRK3 87 10
NEK6 88 20
PIM2 88 2
MNK1 88 10
CAMK1 90 13
MINK1 90 8
ABL 91 12
BRSK2 91 1
SmMLCK 92 8
PINK 92 22
HIPK1 93 32
ERK1 94 1
CK1 delta 94 14
EF2K 94 2
BRSK1 96 25
p38 beta MAPK 96 24
MKK2 97 11
HIPK2 97 2
MARK2 97 11
CDK9-Cyclin T1 97 7
PKB alpha 98 11
PKD1 98 9
CK1 gamma 2 98 4
PKB beta 99 3
MARK1 99 2
DAPK1 99 44
OSR1 99 6
MAPKAP-K3 100 2
PRAK 100 4
ERK2 100 1
TBK1 100 12
HIPK3 103 15
WNK1 103 6
TLK1 103 6
p38 alpha MAPK 104 6
EPH-A4 104 1
MKK1 105 56
SRPK1 106 3
TGFBR1 107 8
TTBK1 108 1
ASK1 108 2
MAPKAP-K2 108 1
p38 gamma MAPK 110 24
PIM1 112 9
PKC zeta 113 8
MST3 115 19
TTBK2 116 2
BRK 117 6
VEGFR1 118 30
MEKK1 122 37
TrkA 135 2
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
JAK2 3 8
MLK1 6 0
EPH-A4 10 0
EPH-B1 10 2
MLK3 21 3
EPH-B4 22 3
Aurora B 23 2
IGF-1R 25 4
Aurora A 29 32
BTK 29 1
VEGFR1 31 5
EPH-A2 34 2
TrkA 35 1
PAK4 37 2
Src 41 5
ZAP70 51 0
EPH-B2 53 7
IRR 59 20
Lck 61 1
YES1 64 2
HER4 65 1
DDR2 66 1
ULK1 68 8
NUAK1 70 1
IKK epsilon 72 1
S6K1 73 7
SYK 73 9
FGF-R1 75 8
PAK5 75 5
EPH-B3 76 5
JNK3 77 1
TBK1 82 14
SGK1 85 5
JNK2 85 7
ERK8 86 6
CSK 86 19
SIK3 86 9
RSK2 87 16
AMPK (hum) 87 3
ULK2 88 10
IRAK1 88 5
MSK1 89 2
PDK1 89 15
TLK1 89 12
DYRK3 92 2
IRAK4 92 0
TSSK1 93 14
MST4 93 2
RSK1 94 24
MARK2 94 7
GSK3 beta 94 12
PDGFRA 94 13
MINK1 95 7
DYRK1A 95 0
MARK4 95 6
BRSK2 95 1
RIPK2 95 8
PKD1 95 7
BRK 95 7
GCK 95 0
ERK5 96 13
ROCK 2 96 5
p38 beta MAPK 96 14
SIK2 96 12
TTK 96 10
EIF2AK3 97 0
JNK1 97 8
STK33 97 4
MKK2 98 5
MAPKAP-K3 98 8
CAMK1 98 9
CLK2 98 11
TAO1 98 8
IR 98 8
CHK2 98 1
MELK 98 2
PLK1 99 6
TESK1 99 7
PAK2 99 4
PHK 99 1
MNK2 100 6
ERK1 100 0
PRK2 100 6
TIE2 100 4
ERK2 101 1
DYRK2 101 5
DAPK1 101 7
CAMKK beta 102 15
PKC gamma 102 2
OSR1 102 7
p38 delta MAPK 102 6
WNK1 103 8
MARK3 103 8
TAK1 103 23
MST3 103 8
PIM1 103 1
PIM2 103 2
PIM3 104 10
MNK1 104 21
SRPK1 104 3
p38 alpha MAPK 104 11
EF2K 105 10
CK2 105 18
MKK6 105 1
PRAK 105 11
SmMLCK 105 11
NEK2a 105 1
CHK1 105 0
PKC alpha 106 0
MAPKAP-K2 107 5
PKB alpha 107 11
MARK1 108 8
NEK6 108 4
PINK 108 3
MPSK1 108 6
MAP4K3 109 3
CK1 gamma 2 109 3
CK1 delta 109 8
MEKK1 109 1
HIPK1 109 8
HIPK2 109 3
IKK beta 109 9
CDK2-Cyclin A 110 9
PKA 111 7
PAK6 111 19
CDK9-Cyclin T1 111 10
TGFBR1 112 6
ABL 112 4
BRSK1 112 1
MAP4K5 113 0
MKK1 113 0
TTBK1 113 7
HIPK3 113 0
LKB1 115 6
PKC zeta 115 1
PKB beta 118 0
TTBK2 121 2
ASK1 123 1
p38 gamma MAPK 134 7
MST2 145 38
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
EPH-B1 48 1
EPH-A4 49 2
MLK1 50 2
JAK2 50 6
MLK3 58 1
Aurora B 60 3
EPH-A2 62 3
TrkA 62 0
PIM3 63 8
BTK 67 3
NUAK1 72 0
PAK4 72 8
VEGFR1 74 14
Aurora A 75 42
EPH-B4 78 9
SYK 79 0
Src 80 2
TSSK1 83 3
TLK1 84 3
DYRK3 86 3
YES1 87 4
p38 alpha MAPK 89 7
TBK1 89 1
MKK1 89 24
EPH-B2 90 4
PAK5 90 6
IKK epsilon 91 1
DDR2 91 12
GSK3 beta 92 12
PRAK 92 7
JNK2 92 5
MARK1 93 13
DYRK1A 93 23
OSR1 94 2
TIE2 94 2
PAK2 94 3
MARK3 95 2
MSK1 96 4
PLK1 96 2
RSK1 96 14
MEKK1 96 3
TESK1 96 1
MARK4 96 5
ZAP70 97 3
CK1 delta 97 6
CAMK1 97 1
MARK2 97 2
BRK 98 7
MAPKAP-K3 98 7
SGK1 98 7
HER4 98 3
ERK5 98 8
BRSK2 98 2
SIK3 99 9
WNK1 99 6
ULK2 99 9
CSK 99 12
ASK1 99 3
ROCK 2 99 2
MELK 100 6
RSK2 100 11
PRK2 100 17
CK2 101 19
DYRK2 101 1
TAO1 101 3
NEK6 101 8
PKC alpha 101 9
p38 delta MAPK 102 9
SRPK1 102 4
NEK2a 102 4
IRAK1 102 3
MAP4K3 103 5
MNK2 103 3
TTBK1 103 10
JNK1 103 10
BRSK1 103 0
CDK9-Cyclin T1 104 16
SmMLCK 104 15
CHK2 105 1
MST4 105 5
EIF2AK3 105 7
MKK6 105 1
HIPK2 105 10
PKA 105 17
IRAK4 105 3
SIK2 106 21
TTK 106 1
PIM2 106 2
GCK 106 15
PDK1 106 12
TGFBR1 106 5
RIPK2 107 10
ERK8 107 2
MNK1 107 7
CK1 gamma 2 107 13
Lck 107 2
CDK2-Cyclin A 108 5
PINK 108 4
EPH-B3 108 0
ERK1 108 32
EF2K 109 5
PKB alpha 109 13
PKC gamma 110 0
PKD1 110 5
p38 beta MAPK 112 17
AMPK (hum) 112 3
CLK2 112 6
IRR 112 18
JNK3 112 6
CHK1 112 11
ABL 113 3
PHK 113 5
MST2 114 6
MST3 114 8
DAPK1 114 4
PDGFRA 115 1
MKK2 115 1
FGF-R1 115 2
S6K1 115 9
STK33 116 8
MINK1 116 3
MAPKAP-K2 116 3
PKB beta 116 3
IR 116 9
CAMKK beta 117 13
IKK beta 117 4
LKB1 119 6
HIPK1 119 12
HIPK3 119 13
ULK1 120 9
TAK1 120 24
PKC zeta 122 7
TTBK2 122 5
PAK6 123 14
ERK2 125 7
MAP4K5 126 8
p38 gamma MAPK 129 1
PIM1 129 4
MPSK1 137 35
IGF-1R 137 19

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