Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Fostamatinib C23H26FN6O9P 580.46 Seleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 105 56
MKK2 97 11
MKK6 83 4
ERK1 94 1
ERK2 100 1
ERK5 84 6
JNK1 70 44
JNK2 26 1
JNK3 24 2
p38 alpha MAPK 104 6
p38 beta MAPK 96 24
p38 gamma MAPK 110 24
p38 delta MAPK 71 6
ERK8 36 0
RSK1 62 17
RSK2 78 35
PDK1 74 55
PKB alpha 98 11
PKB beta 99 3
SGK1 30 3
S6K1 27 1
PKA 61 0
ROCK 2 86 4
PRK2 69 8
PKC alpha 78 2
PKC gamma 86 5
PKC zeta 113 8
PKD1 98 9
STK33 73 55
MSK1 71 7
MNK1 88 10
MNK2 71 4
MAPKAP-K2 108 1
MAPKAP-K3 100 2
PRAK 100 4
CAMKK beta 66 20
CAMK1 90 13
SmMLCK 92 8
PHK 86 6
DAPK1 99 44
CHK1 81 3
CHK2 74 33
GSK3 beta 76 0
CDK2-Cyclin A 84 1
CDK9-Cyclin T1 97 7
PLK1 55 4
Aurora A 45 62
Aurora B 46 55
TLK1 103 6
LKB1 37 2
AMPK (hum) 28 0
MARK1 99 2
MARK2 97 11
MARK3 87 43
MARK4 76 9
BRSK1 96 25
BRSK2 91 1
MELK 85 14
NUAK1 19 0
SIK2 37 7
SIK3 72 9
TSSK1 43 0
CK1 gamma 2 98 4
CK1 delta 94 14
CK2 62 5
TTBK1 108 1
TTBK2 116 2
DYRK1A 80 2
DYRK2 74 7
DYRK3 87 10
NEK2a 58 1
NEK6 88 20
IKK beta 77 10
IKK epsilon 19 2
TBK1 100 12
PIM1 112 9
PIM2 88 2
PIM3 84 3
SRPK1 106 3
EF2K 94 2
EIF2AK3 55 4
HIPK1 93 32
HIPK2 97 2
HIPK3 103 15
CLK2 39 0
PAK2 59 6
PAK4 6 0
PAK5 27 8
PAK6 64 6
MST2 64 15
MST3 115 19
MST4 79 8
GCK 86 54
MAP4K3 60 0
MAP4K5 75 4
MINK1 90 8
MEKK1 122 37
MLK1 4 0
MLK3 4 0
TESK1 46 6
TAO1 74 8
ASK1 108 2
TAK1 63 13
IRAK1 24 3
IRAK4 62 4
RIPK2 82 4
OSR1 99 6
TTK 74 4
MPSK1 66 8
WNK1 103 6
ULK1 16 0
ULK2 30 2
TGFBR1 107 8
Src 86 7
Lck 8 2
CSK 16 2
YES1 17 0
ABL 91 12
BTK 15 0
JAK2 -5 12
SYK 54 49
ZAP70 7 1
TIE2 68 4
BRK 117 6
EPH-A2 9 2
EPH-A4 104 1
EPH-B1 3 0
EPH-B2 6 1
EPH-B3 31 6
EPH-B4 48 58
FGF-R1 22 1
HER4 25 3
IGF-1R 7 1
IR 11 0
IRR 18 0
TrkA 135 2
DDR2 14 5
VEGFR1 118 30
PDGFRA 73 66
PINK 92 22
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 113 0
MKK2 98 5
MKK6 105 1
ERK1 100 0
ERK2 101 1
ERK5 96 13
JNK1 97 8
JNK2 85 7
JNK3 77 1
p38 alpha MAPK 104 11
p38 beta MAPK 96 14
p38 gamma MAPK 134 7
p38 delta MAPK 102 6
ERK8 86 6
RSK1 94 24
RSK2 87 16
PDK1 89 15
PKB alpha 107 11
PKB beta 118 0
SGK1 85 5
S6K1 73 7
PKA 111 7
ROCK 2 96 5
PRK2 100 6
PKC alpha 106 0
PKC gamma 102 2
PKC zeta 115 1
PKD1 95 7
STK33 97 4
MSK1 89 2
MNK1 104 21
MNK2 100 6
MAPKAP-K2 107 5
MAPKAP-K3 98 8
PRAK 105 11
CAMKK beta 102 15
CAMK1 98 9
SmMLCK 105 11
PHK 99 1
DAPK1 101 7
CHK1 105 0
CHK2 98 1
GSK3 beta 94 12
CDK2-Cyclin A 110 9
CDK9-Cyclin T1 111 10
PLK1 99 6
Aurora A 29 32
Aurora B 23 2
TLK1 89 12
LKB1 115 6
AMPK (hum) 87 3
MARK1 108 8
MARK2 94 7
MARK3 103 8
MARK4 95 6
BRSK1 112 1
BRSK2 95 1
MELK 98 2
NUAK1 70 1
SIK2 96 12
SIK3 86 9
TSSK1 93 14
CK1 gamma 2 109 3
CK1 delta 109 8
CK2 105 18
TTBK1 113 7
TTBK2 121 2
DYRK1A 95 0
DYRK2 101 5
DYRK3 92 2
NEK2a 105 1
NEK6 108 4
IKK beta 109 9
IKK epsilon 72 1
TBK1 82 14
PIM1 103 1
PIM2 103 2
PIM3 104 10
SRPK1 104 3
EF2K 105 10
EIF2AK3 97 0
HIPK1 109 8
HIPK2 109 3
HIPK3 113 0
CLK2 98 11
PAK2 99 4
PAK4 37 2
PAK5 75 5
PAK6 111 19
MST2 145 38
MST3 103 8
MST4 93 2
GCK 95 0
MAP4K3 109 3
MAP4K5 113 0
MINK1 95 7
MEKK1 109 1
MLK1 6 0
MLK3 21 3
TESK1 99 7
TAO1 98 8
ASK1 123 1
TAK1 103 23
IRAK1 88 5
IRAK4 92 0
RIPK2 95 8
OSR1 102 7
TTK 96 10
MPSK1 108 6
WNK1 103 8
ULK1 68 8
ULK2 88 10
TGFBR1 112 6
Src 41 5
Lck 61 1
CSK 86 19
YES1 64 2
ABL 112 4
BTK 29 1
JAK2 3 8
SYK 73 9
ZAP70 51 0
TIE2 100 4
BRK 95 7
EPH-A2 34 2
EPH-A4 10 0
EPH-B1 10 2
EPH-B2 53 7
EPH-B3 76 5
EPH-B4 22 3
FGF-R1 75 8
HER4 65 1
IGF-1R 25 4
IR 98 8
IRR 59 20
TrkA 35 1
DDR2 66 1
VEGFR1 31 5
PDGFRA 94 13
PINK 108 3
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 89 24
MKK2 115 1
MKK6 105 1
ERK1 108 32
ERK2 125 7
ERK5 98 8
JNK1 103 10
JNK2 92 5
JNK3 112 6
p38 alpha MAPK 89 7
p38 beta MAPK 112 17
p38 gamma MAPK 129 1
p38 delta MAPK 102 9
ERK8 107 2
RSK1 96 14
RSK2 100 11
PDK1 106 12
PKB alpha 109 13
PKB beta 116 3
SGK1 98 7
S6K1 115 9
PKA 105 17
ROCK 2 99 2
PRK2 100 17
PKC alpha 101 9
PKC gamma 110 0
PKC zeta 122 7
PKD1 110 5
STK33 116 8
MSK1 96 4
MNK1 107 7
MNK2 103 3
MAPKAP-K2 116 3
MAPKAP-K3 98 7
PRAK 92 7
CAMKK beta 117 13
CAMK1 97 1
SmMLCK 104 15
PHK 113 5
DAPK1 114 4
CHK1 112 11
CHK2 105 1
GSK3 beta 92 12
CDK2-Cyclin A 108 5
CDK9-Cyclin T1 104 16
PLK1 96 2
Aurora A 75 42
Aurora B 60 3
TLK1 84 3
LKB1 119 6
AMPK (hum) 112 3
MARK1 93 13
MARK2 97 2
MARK3 95 2
MARK4 96 5
BRSK1 103 0
BRSK2 98 2
MELK 100 6
NUAK1 72 0
SIK2 106 21
SIK3 99 9
TSSK1 83 3
CK1 gamma 2 107 13
CK1 delta 97 6
CK2 101 19
TTBK1 103 10
TTBK2 122 5
DYRK1A 93 23
DYRK2 101 1
DYRK3 86 3
NEK2a 102 4
NEK6 101 8
IKK beta 117 4
IKK epsilon 91 1
TBK1 89 1
PIM1 129 4
PIM2 106 2
PIM3 63 8
SRPK1 102 4
EF2K 109 5
EIF2AK3 105 7
HIPK1 119 12
HIPK2 105 10
HIPK3 119 13
CLK2 112 6
PAK2 94 3
PAK4 72 8
PAK5 90 6
PAK6 123 14
MST2 114 6
MST3 114 8
MST4 105 5
GCK 106 15
MAP4K3 103 5
MAP4K5 126 8
MINK1 116 3
MEKK1 96 3
MLK1 50 2
MLK3 58 1
TESK1 96 1
TAO1 101 3
ASK1 99 3
TAK1 120 24
IRAK1 102 3
IRAK4 105 3
RIPK2 107 10
OSR1 94 2
TTK 106 1
MPSK1 137 35
WNK1 99 6
ULK1 120 9
ULK2 99 9
TGFBR1 106 5
Src 80 2
Lck 107 2
CSK 99 12
YES1 87 4
ABL 113 3
BTK 67 3
JAK2 50 6
SYK 79 0
ZAP70 97 3
TIE2 94 2
BRK 98 7
EPH-A2 62 3
EPH-A4 49 2
EPH-B1 48 1
EPH-B2 90 4
EPH-B3 108 0
EPH-B4 78 9
FGF-R1 115 2
HER4 98 3
IGF-1R 137 19
IR 116 9
IRR 112 18
TrkA 62 0
DDR2 91 12
VEGFR1 74 14
PDGFRA 115 1
PINK 108 4

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