Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
OTSSP167 C25H28Cl2N4O2 487.42 MELK Selleck Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 8 1
MKK2 15 1
MKK6 104 11
ERK1 89 8
ERK2 82 4
ERK5 19 10
JNK1 54 3
JNK2 41 3
JNK3 50 11
p38 alpha MAPK 38 0
p38 beta MAPK 18 6
p38 gamma MAPK 22 5
p38 delta MAPK 19 2
ERK8 3 1
RSK1 2 0
RSK2 4 0
PDK1 14 1
PKB alpha 68 12
PKB beta 56 4
SGK1 27 5
S6K1 6 1
PKA 42 8
ROCK 2 60 2
PRK2 3 1
PKC alpha 10 1
PKC gamma 46 28
PKC zeta 50 6
PKD1 18 12
STK33 12 1
MSK1 24 6
MNK1 76 16
MNK2 49 13
MAPKAP-K2 36 2
MAPKAP-K3 88 5
PRAK 62 16
CAMKK beta 4 1
CAMK1 48 3
SmMLCK 13 1
PHK 1 1
DAPK1 1 0
CHK1 34 1
CHK2 1 0
GSK3 beta 2 0
CDK2-Cyclin A 6 1
CDK9-Cyclin T1 11 10
PLK1 16 2
Aurora A 48 2
Aurora B 23 3
TLK1 91 28
LKB1 96 8
AMPK 2 0
AMPK (hum) 2 2
MARK1 75 24
MARK2 60 10
MARK3 46 7
MARK4 41 2
BRSK1 14 4
BRSK2 10 0
MELK 5 3
NUAK1 2 2
SIK2 6 2
SIK3 12 0
TSSK1 5 0
CK1 gamma 2 26 1
CK1 delta 7 0
CK2 1 1
TTBK1 81 9
TTBK2 96 13
DYRK1A 0 0
DYRK2 1 0
DYRK3 1 0
NEK2a 84 13
NEK6 89 6
IKK beta 76 3
IKK epsilon 18 18
TBK1 11 0
PIM1 4 2
PIM2 1 2
PIM3 1 0
SRPK1 50 3
EF2K 99 19
EIF2AK3 23 1
HIPK1 2 1
HIPK2 4 4
HIPK3 1 1
CLK2 1 1
PAK2 102 9
PAK4 18 4
PAK5 61 20
PAK6 70 3
MST2 3 2
MST3 43 6
MST4 19 2
GCK 1 1
MAP4K3 2 1
MAP4K5 2 3
MINK1 3 0
MEKK1 91 5
MLK1 3 1
MLK3 2 1
TESK1 75 16
TAO1 3 0
ASK1 61 1
TAK1 0 1
IRAK1 9 1
IRAK4 6 1
RIPK2 3 1
OSR1 90 1
TTK 6 1
MPSK1 57 12
WNK1 110 6
ULK1 52 0
ULK2 14 1
TGFBR1 73 0
Src 9 6
Lck 1 0
CSK 86 10
YES1 8 4
ABL 2 0
BTK 16 11
JAK2 3 0
SYK 35 1
ZAP70 126 2
TIE2 20 9
BRK 31 2
EPH-A2 4 1
EPH-A4 2 0
EPH-B1 5 2
EPH-B2 1 0
EPH-B3 9 7
EPH-B4 60 5
FGF-R1 12 0
HER4 16 0
IGF-1R 8 3
IR 8 2
IRR 19 2
TrkA 7 2
DDR2 1 0
VEGFR1 2 1
PDGFRA 4 1
PINK 92 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 3 0
MKK2 10 1
MKK6 80 2
ERK1 88 1
ERK2 90 5
ERK5 4 1
JNK1 10 1
JNK2 16 1
JNK3 13 1
p38 alpha MAPK 10 1
p38 beta MAPK 6 0
p38 gamma MAPK 12 5
p38 delta MAPK 4 1
ERK8 1 1
RSK1 3 2
RSK2 1 1
PDK1 4 1
PKB alpha 28 1
PKB beta 24 2
SGK1 12 0
S6K1 2 0
PKA 12 0
ROCK 2 49 1
PRK2 2 0
PKC alpha 7 1
PKC gamma 1 0
PKC zeta 19 1
PKD1 6 0
STK33 10 1
MSK1 5 0
MNK1 28 0
MNK2 13 2
MAPKAP-K2 14 4
MAPKAP-K3 94 0
PRAK 16 0
CAMKK beta 2 1
CAMK1 15 1
SmMLCK 6 3
PHK 3 4
DAPK1 1 0
CHK1 11 1
CHK2 1 0
GSK3 beta 0 0
CDK2-Cyclin A 2 0
CDK9-Cyclin T1 4 1
PLK1 3 0
Aurora A 10 1
Aurora B 14 1
TLK1 58 1
LKB1 83 8
AMPK 2 0
AMPK (hum) 1 0
MARK1 31 1
MARK2 23 1
MARK3 13 3
MARK4 14 0
BRSK1 2 0
BRSK2 2 2
MELK 6 1
NUAK1 0 2
SIK2 2 0
SIK3 4 1
TSSK1 1 0
CK1 gamma 2 10 3
CK1 delta 6 5
CK2 1 0
TTBK1 82 6
TTBK2 91 8
DYRK1A 1 0
DYRK2 1 0
DYRK3 1 1
NEK2a 59 11
NEK6 92 3
IKK beta 41 1
IKK epsilon 2 0
TBK1 6 1
PIM1 10 1
PIM2 0 0
PIM3 1 0
SRPK1 10 1
EF2K 114 5
EIF2AK3 7 0
HIPK1 0 0
HIPK2 2 2
HIPK3 0 0
CLK2 0 0
PAK2 74 10
PAK4 9 2
PAK5 19 1
PAK6 29 3
MST2 7 2
MST3 5 0
MST4 5 1
GCK 0 0
MAP4K3 1 0
MAP4K5 3 1
MINK1 2 1
MEKK1 96 19
MLK1 1 1
MLK3 2 1
TESK1 51 9
TAO1 3 0
ASK1 7 2
TAK1 1 0
IRAK1 3 1
IRAK4 7 1
RIPK2 4 0
OSR1 45 3
TTK 3 2
MPSK1 5 0
WNK1 111 5
ULK1 32 0
ULK2 4 0
TGFBR1 16 1
Src 5 3
Lck 0 0
CSK 9 6
YES1 18 9
ABL 1 0
BTK 7 3
JAK2 3 1
SYK 7 1
ZAP70 78 13
TIE2 3 0
BRK 8 3
EPH-A2 7 0
EPH-A4 1 1
EPH-B1 11 2
EPH-B2 1 1
EPH-B3 18 7
EPH-B4 2 0
FGF-R1 4 1
HER4 4 0
IGF-1R 4 0
IR 2 0
IRR 6 2
TrkA 1 2
DDR2 0 0
VEGFR1 1 0
PDGFRA 20 23
PINK 89 13

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