Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CAY10576 C22H19N3O5S2 469.5 IKKe Cayman Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 3
MKK2 111 4
MKK6 100 9
ERK1 92 0
ERK2 84 3
ERK5 98 2
JNK1 100 5
JNK2 107 9
JNK3 104 1
p38 alpha MAPK 109 5
p38 beta MAPK 113 0
p38 gamma MAPK 102 9
p38 delta MAPK 99 3
ERK8 90 6
RSK1 96 5
RSK2 96 4
PDK1 90 13
PKB alpha 105 3
PKB beta 103 5
SGK1 95 9
S6K1 85 1
PKA 89 1
ROCK 2 73 3
PRK2 107 1
PKC alpha 100 4
PKC gamma 98 1
PKC zeta 92 2
PKD1 106 8
STK33 99 5
MSK1 96 0
MNK1 97 6
MNK2 91 5
MAPKAP-K2 88 6
MAPKAP-K3 84 2
PRAK 115 21
CAMKK beta 97 1
CAMK1 107 3
SmMLCK 100 4
PHK 114 1
DAPK1 96 0
CHK1 102 12
CHK2 90 2
GSK3 beta 102 4
CDK2-Cyclin A 90 7
CDK9-Cyclin T1 107 18
PLK1 107 4
Aurora A 102 3
Aurora B 100 6
TLK1 97 2
LKB1 138 17
AMPK 94 1
AMPK (hum) 87 4
MARK1 112 7
MARK2 99 2
MARK3 96 15
MARK4 91 0
BRSK1 113 0
BRSK2 114 11
MELK 94 4
NUAK1 109 15
SIK2 105 10
SIK3 94 8
TSSK1 108 9
CK1 gamma 2 102 3
CK1 delta 97 10
CK2 103 6
TTBK1 123 7
TTBK2 89 4
DYRK1A 110 6
DYRK2 106 1
DYRK3 98 13
NEK2a 102 9
NEK6 103 1
IKK beta 105 17
IKK epsilon 107 9
TBK1 107 5
PIM1 95 11
PIM2 105 7
PIM3 108 7
SRPK1 103 7
EF2K 94 3
EIF2AK3 106 5
HIPK1 71 3
HIPK2 108 15
HIPK3 79 14
CLK2 96 8
PAK2 117 2
PAK4 92 16
PAK5 107 4
PAK6 106 1
MST2 81 11
MST3 73 11
MST4 75 6
GCK 95 7
MAP4K3 81 7
MAP4K5 70 15
MINK1 85 1
MEKK1 104 4
MLK1 64 3
MLK3 104 2
TESK1 92 6
TAO1 79 10
ASK1 109 14
TAK1 100 2
IRAK1 97 14
IRAK4 96 4
RIPK2 98 14
OSR1 107 11
TTK 100 5
MPSK1 98 9
WNK1 95 1
ULK1 72 4
ULK2 95 6
TGFBR1 108 3
Src 130 5
Lck 101 2
CSK 98 2
YES1 87 1
ABL 98 5
BTK 99 18
JAK2 117 1
SYK 95 1
ZAP70 110 2
TIE2 76 10
BRK 79 2
EPH-A2 106 11
EPH-A4 104 1
EPH-B1 99 6
EPH-B2 119 17
EPH-B3 81 3
EPH-B4 99 18
FGF-R1 80 1
HER4 100 11
IGF-1R 89 9
IR 116 21
IRR 107 5
TrkA 90 6
DDR2 103 14
VEGFR1 74 10
PDGFRA 107 0
PINK 79 9
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 19
MKK2 99 2
MKK6 88 3
ERK1 90 2
ERK2 79 9
ERK5 103 10
JNK1 92 7
JNK2 103 13
JNK3 96 3
p38 alpha MAPK 111 7
p38 beta MAPK 92 5
p38 gamma MAPK 99 7
p38 delta MAPK 98 1
ERK8 85 2
RSK1 87 6
RSK2 87 9
PDK1 90 9
PKB alpha 94 2
PKB beta 95 6
SGK1 99 7
S6K1 88 3
PKA 109 12
ROCK 2 61 5
PRK2 92 4
PKC alpha 103 3
PKC gamma 96 4
PKC zeta 91 7
PKD1 109 8
STK33 105 3
MSK1 98 4
MNK1 93 1
MNK2 95 13
MAPKAP-K2 88 15
MAPKAP-K3 75 7
PRAK 105 7
CAMKK beta 107 8
CAMK1 105 1
SmMLCK 102 15
PHK 103 7
DAPK1 96 3
CHK1 94 15
CHK2 79 3
GSK3 beta 106 15
CDK2-Cyclin A 88 9
CDK9-Cyclin T1 100 8
PLK1 113 8
Aurora A 98 13
Aurora B 91 5
TLK1 100 8
LKB1 123 5
AMPK 97 1
AMPK (hum) 91 15
MARK1 94 9
MARK2 95 2
MARK3 104 2
MARK4 88 8
BRSK1 113 7
BRSK2 98 9
MELK 103 0
NUAK1 104 11
SIK2 97 9
SIK3 106 1
TSSK1 96 4
CK1 gamma 2 99 8
CK1 delta 100 5
CK2 91 14
TTBK1 113 14
TTBK2 116 17
DYRK1A 103 4
DYRK2 108 13
DYRK3 78 2
NEK2a 93 3
NEK6 102 10
IKK beta 104 7
IKK epsilon 88 6
TBK1 110 6
PIM1 104 11
PIM2 109 7
PIM3 93 1
SRPK1 102 11
EF2K 96 4
EIF2AK3 103 1
HIPK1 76 8
HIPK2 106 16
HIPK3 80 1
CLK2 99 3
PAK2 105 1
PAK4 96 3
PAK5 111 9
PAK6 105 4
MST2 77 0
MST3 70 11
MST4 79 6
GCK 90 5
MAP4K3 82 7
MAP4K5 67 3
MINK1 93 22
MEKK1 92 4
MLK1 67 2
MLK3 106 7
TESK1 91 12
TAO1 82 5
ASK1 112 10
TAK1 100 4
IRAK1 98 10
IRAK4 96 4
RIPK2 100 20
OSR1 106 4
TTK 91 8
MPSK1 104 10
WNK1 102 3
ULK1 72 2
ULK2 88 2
TGFBR1 119 22
Src 117 5
Lck 116 5
CSK 105 5
YES1 91 3
ABL 114 1
BTK 96 2
JAK2 99 7
SYK 97 5
ZAP70 103 15
TIE2 83 2
BRK 72 4
EPH-A2 98 14
EPH-A4 88 9
EPH-B1 92 1
EPH-B2 123 9
EPH-B3 75 24
EPH-B4 100 2
FGF-R1 91 3
HER4 105 7
IGF-1R 82 9
IR 105 24
IRR 99 12
TrkA 90 10
DDR2 104 4
VEGFR1 89 4
PDGFRA 90 1
PINK 80 3

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