Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Amgen-NIK-28 C20H20N4O 332.4 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 22 2
MKK2 39 7
MKK6 46 24
ERK1 96 6
ERK2 95 5
ERK5 47 3
JNK1 86 17
JNK2 86 6
JNK3 89 10
p38 alpha MAPK 113 7
p38 beta MAPK 100 0
p38 gamma MAPK 34 1
p38 delta MAPK 88 6
ERK8 85 0
RSK1 81 15
RSK2 94 4
PDK1 101 1
PKB alpha 54 1
PKB beta 46 4
SGK1 68 0
S6K1 101 8
PKA 89 2
ROCK 2 94 1
PRK2 86 6
PKC alpha 102 7
PKC gamma 97 2
PKC zeta 89 8
PKD1 9 3
STK33 52 0
MSK1 102 7
MNK1 108 4
MNK2 92 1
MAPKAP-K2 108 10
MAPKAP-K3 104 7
PRAK 103 10
CAMKK beta 99 2
CAMK1 69 12
SmMLCK 31 0
PHK 80 3
DAPK1 82 1
CHK1 102 5
CHK2 16 3
GSK3 beta 30 2
CDK2-Cyclin A 97 21
CDK9-Cyclin T1 126 1
PLK1 103 1
Aurora A 107 1
Aurora B 72 3
TLK1 99 17
LKB1 81 6
AMPK (hum) 71 5
MARK1 38 15
MARK2 42 1
MARK3 10 1
MARK4 39 3
BRSK1 91 5
BRSK2 84 7
MELK 71 2
NUAK1 33 3
SIK2 77 5
SIK3 87 10
TSSK1 13 0
CK1 gamma 2 92 1
CK1 delta 15 3
CK2 90 3
TTBK1 8 1
TTBK2 12 5
DYRK1A 72 13
DYRK2 76 1
DYRK3 61 2
NEK2a 92 5
NEK6 92 13
IKK beta 82 4
IKK epsilon 28 10
TBK1 90 5
PIM1 92 5
PIM2 108 7
PIM3 89 3
SRPK1 94 17
EF2K 83 9
EIF2AK3 24 4
HIPK1 3 0
HIPK2 39 2
HIPK3 86 26
CLK2 27 5
PAK2 96 11
PAK4 2 2
PAK5 3 1
PAK6 5 1
MST2 65 2
MST3 72 2
MST4 63 3
GCK 37 1
MAP4K3 2 1
MAP4K5 5 1
MINK1 16 0
MEKK1 94 2
MLK1 5 0
MLK3 2 0
TESK1 97 4
TAO1 7 2
ASK1 101 6
TAK1 6 0
IRAK1 97 7
IRAK4 53 10
RIPK2 73 5
OSR1 88 8
TTK 100 1
MPSK1 89 7
WNK1 103 15
ULK1 81 16
ULK2 61 7
TGFBR1 84 9
Src 82 10
Lck 94 6
CSK 119 19
YES1 107 14
ABL 95 7
BTK 117 21
JAK2 10 2
SYK 117 7
ZAP70 103 11
TIE2 97 12
BRK 87 4
EPH-A2 90 2
EPH-A4 119 30
EPH-B1 101 11
EPH-B2 131 16
EPH-B3 87 3
EPH-B4 98 1
FGF-R1 62 2
HER4 108 10
IGF-1R 118 8
IR 72 5
IRR 103 9
TrkA 115 11
DDR2 104 4
VEGFR1 22 2
PDGFRA 96 13
PINK 102 4
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 57 3
MKK2 75 6
MKK6 79 16
ERK1 97 8
ERK2 115 5
ERK5 81 2
JNK1 86 4
JNK2 85 12
JNK3 93 14
p38 alpha MAPK 117 13
p38 beta MAPK 95 5
p38 gamma MAPK 76 0
p38 delta MAPK 86 1
ERK8 96 0
RSK1 83 20
RSK2 89 5
PDK1 111 11
PKB alpha 91 1
PKB beta 90 2
SGK1 110 1
S6K1 97 12
PKA 102 1
ROCK 2 97 1
PRK2 95 3
PKC alpha 102 15
PKC gamma 105 3
PKC zeta 93 5
PKD1 42 1
STK33 87 8
MSK1 105 13
MNK1 89 0
MNK2 95 1
MAPKAP-K2 108 10
MAPKAP-K3 94 21
PRAK 109 12
CAMKK beta 94 7
CAMK1 98 19
SmMLCK 85 1
PHK 97 5
DAPK1 97 14
CHK1 105 3
CHK2 65 5
GSK3 beta 85 2
CDK2-Cyclin A 101 1
CDK9-Cyclin T1 100 3
PLK1 104 16
Aurora A 102 5
Aurora B 90 5
TLK1 101 4
LKB1 92 15
AMPK (hum) 109 14
MARK1 76 16
MARK2 72 4
MARK3 41 6
MARK4 79 0
BRSK1 94 1
BRSK2 101 0
MELK 87 13
NUAK1 77 6
SIK2 81 3
SIK3 103 13
TSSK1 49 2
CK1 gamma 2 103 3
CK1 delta 45 6
CK2 100 9
TTBK1 47 10
TTBK2 52 10
DYRK1A 93 12
DYRK2 91 0
DYRK3 88 6
NEK2a 105 3
NEK6 103 21
IKK beta 95 18
IKK epsilon 87 5
TBK1 104 2
PIM1 108 3
PIM2 115 10
PIM3 109 0
SRPK1 97 10
EF2K 97 4
EIF2AK3 71 7
HIPK1 7 0
HIPK2 77 5
HIPK3 100 1
CLK2 73 3
PAK2 110 2
PAK4 13 3
PAK5 16 1
PAK6 29 1
MST2 99 1
MST3 99 2
MST4 107 1
GCK 99 0
MAP4K3 11 3
MAP4K5 5 0
MINK1 58 4
MEKK1 96 1
MLK1 30 4
MLK3 12 1
TESK1 105 3
TAO1 30 0
ASK1 110 1
TAK1 29 1
IRAK1 103 8
IRAK4 75 6
RIPK2 88 4
OSR1 83 1
TTK 109 0
MPSK1 104 0
WNK1 107 3
ULK1 89 14
ULK2 79 13
TGFBR1 83 1
Src 107 0
Lck 97 5
CSK 124 3
YES1 118 8
ABL 104 13
BTK 113 2
JAK2 39 4
SYK 108 4
ZAP70 98 3
TIE2 113 11
BRK 98 4
EPH-A2 82 7
EPH-A4 106 21
EPH-B1 105 6
EPH-B2 124 7
EPH-B3 87 2
EPH-B4 89 2
FGF-R1 101 14
HER4 104 4
IGF-1R 106 21
IR 96 8
IRR 116 6
TrkA 127 6
DDR2 92 10
VEGFR1 67 5
PDGFRA 88 4
PINK 110 6

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