Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
WP1130 C19H18BrN3O 384.26972 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085. V Kapuria (2010) Cancer Res 70(22) 9265-9276 Download

Results as Barchart

View results as a bar chart
5µM
1µM

Results as Table

Screening Concentration: 5µM
Kinase % Activity Remaining Standard Deviation
MKK1 115 2
MKK1 115 2
MKK2 123 19
MKK2 123 19
MKK6 94 7
MKK6 94 7
ERK1 96 10
ERK1 96 10
ERK2 106 2
ERK2 106 2
ERK5 111 7
ERK5 111 7
JNK1 96 13
JNK1 96 13
JNK2 93 26
JNK2 93 26
JNK3 87 7
JNK3 87 7
p38 alpha MAPK 96 11
p38 alpha MAPK 96 11
p38 beta MAPK 97 3
p38 beta MAPK 97 3
p38 gamma MAPK 104 4
p38 gamma MAPK 104 4
p38 delta MAPK 93 11
p38 delta MAPK 93 11
ERK8 86 15
ERK8 86 15
RSK1 85 5
RSK1 85 5
RSK2 98 12
RSK2 98 12
PDK1 99 16
PDK1 99 16
PKB alpha 94 27
PKB alpha 94 27
PKB beta 91 10
PKB beta 91 10
SGK1 98 8
SGK1 98 8
S6K1 96 21
S6K1 96 21
PKA 103 11
PKA 103 11
ROCK 2 90 16
ROCK 2 90 16
PRK2 85 20
PRK2 85 20
PKC alpha 103 9
PKC alpha 103 9
PKC gamma 78 2
PKC gamma 78 2
PKC zeta 118 19
PKC zeta 118 19
PKD1 105 12
PKD1 105 12
STK33 101 11
STK33 101 11
MSK1 110 4
MSK1 110 4
MNK1 98 4
MNK1 98 4
MNK2 102 6
MNK2 102 6
MAPKAP-K2 73 11
MAPKAP-K2 73 11
MAPKAP-K3 98 6
MAPKAP-K3 98 6
PRAK 88 5
PRAK 88 5
CAMKK beta 132 22
CAMKK beta 132 22
CAMK1 75 2
CAMK1 75 2
SmMLCK 74 24
SmMLCK 74 24
PHK 105 9
PHK 105 9
DAPK1 74 11
DAPK1 74 11
CHK1 101 1
CHK1 101 1
CHK2 91 5
CHK2 91 5
GSK3 beta 97 10
GSK3 beta 97 10
CDK2-Cyclin A 97 6
CDK2-Cyclin A 97 6
CDK9-Cyclin T1 94 6
CDK9-Cyclin T1 94 6
PLK1 98 36
PLK1 98 36
Aurora A 82 28
Aurora A 82 28
Aurora B 86 8
Aurora B 86 8
TLK1 101 2
TLK1 101 2
LKB1 126 3
LKB1 126 3
AMPK 104 6
AMPK 104 6
AMPK (hum) 108 2
AMPK (hum) 108 2
MARK1 107 5
MARK1 107 5
MARK2 92 6
MARK2 92 6
MARK3 120 9
MARK3 120 9
MARK4 100 7
MARK4 100 7
BRSK1 102 7
BRSK1 102 7
BRSK2 102 3
BRSK2 102 3
MELK 106 3
MELK 106 3
NUAK1 101 17
NUAK1 101 17
SIK2 99 12
SIK2 99 12
SIK3 102 14
SIK3 102 14
TSSK1 91 12
TSSK1 91 12
CK1 gamma 2 102 10
CK1 gamma 2 102 10
CK1 delta 93 4
CK1 delta 93 4
CK2 101 29
CK2 101 29
TTBK1 91 3
TTBK1 91 3
TTBK2 99 9
TTBK2 99 9
DYRK1A 107 32
DYRK1A 107 32
DYRK2 105 10
DYRK2 105 10
DYRK3 107 3
DYRK3 107 3
NEK2a 101 30
NEK2a 101 30
NEK6 101 8
NEK6 101 8
IKK beta 82 4
IKK beta 82 4
IKK epsilon 93 6
IKK epsilon 93 6
TBK1 98 4
TBK1 98 4
PIM1 89 9
PIM1 89 9
PIM2 112 4
PIM2 112 4
PIM3 95 29
PIM3 95 29
SRPK1 103 10
SRPK1 103 10
EF2K 101 21
EF2K 101 21
EIF2AK3 92 5
EIF2AK3 92 5
HIPK1 107 10
HIPK1 107 10
HIPK2 90 6
HIPK2 90 6
HIPK3 100 16
HIPK3 100 16
CLK2 104 3
CLK2 104 3
PAK2 95 2
PAK2 95 2
PAK4 100 13
PAK4 100 13
PAK5 95 3
PAK5 95 3
PAK6 107 1
PAK6 107 1
MST2 110 0
MST2 110 0
MST3 102 6
MST3 102 6
MST4 111 13
MST4 111 13
GCK 90 1
GCK 90 1
MAP4K3 78 7
MAP4K3 78 7
MAP4K5 91 7
MAP4K5 91 7
MINK1 106 0
MINK1 106 0
MEKK1 95 13
MEKK1 95 13
MLK1 101 12
MLK1 101 12
MLK3 110 7
MLK3 110 7
TESK1 98 7
TESK1 98 7
TAO1 104 9
TAO1 104 9
ASK1 108 3
ASK1 108 3
TAK1 134 17
TAK1 134 17
IRAK1 96 34
IRAK1 96 34
IRAK4 95 22
IRAK4 95 22
RIPK2 107 11
RIPK2 107 11
OSR1 92 12
OSR1 92 12
TTK 101 16
TTK 101 16
MPSK1 103 3
MPSK1 103 3
WNK1 102 3
WNK1 102 3
ULK1 92 11
ULK1 92 11
ULK2 96 2
ULK2 96 2
TGFBR1 95 2
TGFBR1 95 2
Src 81 6
Src 81 6
Lck 93 9
Lck 93 9
CSK 105 1
CSK 105 1
YES1 111 2
YES1 111 2
ABL 92 8
ABL 92 8
BTK 101 10
BTK 101 10
JAK2 97 23
JAK2 97 23
SYK 119 1
SYK 119 1
ZAP70 103 7
ZAP70 103 7
TIE2 104 1
TIE2 104 1
BRK 104 16
BRK 104 16
EPH-A2 106 6
EPH-A2 106 6
EPH-A4 138 25
EPH-A4 138 25
EPH-B1 114 8
EPH-B1 114 8
EPH-B2 124 20
EPH-B2 124 20
EPH-B3 119 10
EPH-B3 119 10
EPH-B4 104 0
EPH-B4 104 0
FGF-R1 89 2
FGF-R1 89 2
HER4 89 7
HER4 89 7
IGF-1R 117 14
IGF-1R 117 14
IR 119 11
IR 119 11
IRR 108 20
IRR 108 20
TrkA 102 16
TrkA 102 16
DDR2 89 14
DDR2 89 14
VEGFR1 91 7
VEGFR1 91 7
PDGFRA 94 6
PDGFRA 94 6
PINK 109 20
PINK 109 20
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 116 24
MKK1 116 24
MKK2 113 15
MKK2 113 15
MKK6 86 2
MKK6 86 2
ERK1 85 1
ERK1 85 1
ERK2 90 4
ERK2 90 4
ERK5 111 3
ERK5 111 3
JNK1 89 0
JNK1 89 0
JNK2 78 17
JNK2 78 17
JNK3 86 2
JNK3 86 2
p38 alpha MAPK 104 11
p38 alpha MAPK 104 11
p38 beta MAPK 91 6
p38 beta MAPK 91 6
p38 gamma MAPK 104 6
p38 gamma MAPK 104 6
p38 delta MAPK 97 11
p38 delta MAPK 97 11
ERK8 93 15
ERK8 93 15
RSK1 99 23
RSK1 99 23
RSK2 96 9
RSK2 96 9
PDK1 89 20
PDK1 89 20
PKB alpha 79 29
PKB alpha 79 29
PKB beta 99 2
PKB beta 99 2
SGK1 93 1
SGK1 93 1
S6K1 103 23
S6K1 103 23
PKA 108 16
PKA 108 16
ROCK 2 84 6
ROCK 2 84 6
PRK2 87 1
PRK2 87 1
PKC alpha 87 4
PKC alpha 87 4
PKC gamma 90 16
PKC gamma 90 16
PKC zeta 116 2
PKC zeta 116 2
PKD1 106 6
PKD1 106 6
STK33 91 5
STK33 91 5
MSK1 106 3
MSK1 106 3
MNK1 95 2
MNK1 95 2
MNK2 112 7
MNK2 112 7
MAPKAP-K2 61 5
MAPKAP-K2 61 5
MAPKAP-K3 108 25
MAPKAP-K3 108 25
PRAK 91 4
PRAK 91 4
CAMKK beta 117 7
CAMKK beta 117 7
CAMK1 87 10
CAMK1 87 10
SmMLCK 82 10
SmMLCK 82 10
PHK 97 14
PHK 97 14
DAPK1 95 36
DAPK1 95 36
CHK1 99 10
CHK1 99 10
CHK2 91 13
CHK2 91 13
GSK3 beta 98 17
GSK3 beta 98 17
CDK2-Cyclin A 88 1
CDK2-Cyclin A 88 1
CDK9-Cyclin T1 98 11
CDK9-Cyclin T1 98 11
PLK1 88 13
PLK1 88 13
Aurora A 93 17
Aurora A 93 17
Aurora B 93 6
Aurora B 93 6
TLK1 112 7
TLK1 112 7
LKB1 111 2
LKB1 111 2
AMPK 99 13
AMPK 99 13
AMPK (hum) 88 14
AMPK (hum) 88 14
MARK1 101 17
MARK1 101 17
MARK2 112 20
MARK2 112 20
MARK3 103 11
MARK3 103 11
MARK4 99 7
MARK4 99 7
BRSK1 99 5
BRSK1 99 5
BRSK2 121 5
BRSK2 121 5
MELK 99 22
MELK 99 22
NUAK1 100 8
NUAK1 100 8
SIK2 98 7
SIK2 98 7
SIK3 88 23
SIK3 88 23
TSSK1 91 8
TSSK1 91 8
CK1 gamma 2 108 10
CK1 gamma 2 108 10
CK1 delta 91 0
CK1 delta 91 0
CK2 85 12
CK2 85 12
TTBK1 102 3
TTBK1 102 3
TTBK2 99 3
TTBK2 99 3
DYRK1A 88 19
DYRK1A 88 19
DYRK2 116 24
DYRK2 116 24
DYRK3 103 9
DYRK3 103 9
NEK2a 102 7
NEK2a 102 7
NEK6 92 14
NEK6 92 14
IKK beta 95 5
IKK beta 95 5
IKK epsilon 107 5
IKK epsilon 107 5
TBK1 99 4
TBK1 99 4
PIM1 111 13
PIM1 111 13
PIM2 113 6
PIM2 113 6
PIM3 94 6
PIM3 94 6
SRPK1 97 7
SRPK1 97 7
EF2K 93 5
EF2K 93 5
EIF2AK3 93 9
EIF2AK3 93 9
HIPK1 103 9
HIPK1 103 9
HIPK2 102 6
HIPK2 102 6
HIPK3 102 18
HIPK3 102 18
CLK2 96 2
CLK2 96 2
PAK2 98 0
PAK2 98 0
PAK4 92 13
PAK4 92 13
PAK5 91 14
PAK5 91 14
PAK6 99 5
PAK6 99 5
MST2 97 26
MST2 97 26
MST3 111 14
MST3 111 14
MST4 107 8
MST4 107 8
GCK 97 2
GCK 97 2
MAP4K3 89 18
MAP4K3 89 18
MAP4K5 89 12
MAP4K5 89 12
MINK1 105 17
MINK1 105 17
MEKK1 103 1
MEKK1 103 1
MLK1 111 3
MLK1 111 3
MLK3 100 20
MLK3 100 20
TESK1 76 13
TESK1 76 13
TAO1 102 9
TAO1 102 9
ASK1 111 5
ASK1 111 5
TAK1 128 25
TAK1 128 25
IRAK1 100 7
IRAK1 100 7
IRAK4 95 6
IRAK4 95 6
RIPK2 100 27
RIPK2 100 27
OSR1 96 2
OSR1 96 2
TTK 106 1
TTK 106 1
MPSK1 93 7
MPSK1 93 7
WNK1 104 9
WNK1 104 9
ULK1 91 11
ULK1 91 11
ULK2 104 13
ULK2 104 13
TGFBR1 106 1
TGFBR1 106 1
Src 100 10
Src 100 10
Lck 89 3
Lck 89 3
CSK 89 19
CSK 89 19
YES1 126 16
YES1 126 16
ABL 98 9
ABL 98 9
BTK 113 6
BTK 113 6
JAK2 103 17
JAK2 103 17
SYK 116 11
SYK 116 11
ZAP70 104 1
ZAP70 104 1
TIE2 108 12
TIE2 108 12
BRK 109 18
BRK 109 18
EPH-A2 104 5
EPH-A2 104 5
EPH-A4 136 9
EPH-A4 136 9
EPH-B1 110 3
EPH-B1 110 3
EPH-B2 126 27
EPH-B2 126 27
EPH-B3 107 11
EPH-B3 107 11
EPH-B4 103 7
EPH-B4 103 7
FGF-R1 105 23
FGF-R1 105 23
HER4 108 16
HER4 108 16
IGF-1R 112 14
IGF-1R 112 14
IR 125 7
IR 125 7
IRR 109 12
IRR 109 12
TrkA 99 11
TrkA 99 11
DDR2 108 6
DDR2 108 6
VEGFR1 84 1
VEGFR1 84 1
PDGFRA 102 3
PDGFRA 102 3
PINK 98 15
PINK 98 15

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