Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Leflunomide C12H9F3N2O2 270.20727 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 109 14
MKK2 107 7
MKK6 99 6
ERK1 103 1
ERK2 122 26
ERK5 94 0
JNK1 93 3
JNK2 120 12
JNK3 105 9
p38 alpha MAPK 107 17
p38 beta MAPK 113 10
p38 gamma MAPK 99 5
p38 delta MAPK 93 13
ERK8 90 7
RSK1 114 4
RSK2 94 5
PDK1 105 6
PKB alpha 103 2
PKB beta 114 4
SGK1 106 3
S6K1 98 1
PKA 89 4
ROCK 2 90 8
PRK2 105 13
PKC alpha 105 14
PKC gamma 98 12
PKC zeta 119 13
PKD1 139 24
STK33 104 11
MSK1 98 5
MNK1 98 10
MNK2 109 13
MAPKAP-K2 92 0
MAPKAP-K3 94 12
PRAK 73 2
CAMKK beta 91 6
CAMK1 102 2
SmMLCK 132 13
PHK 93 5
DAPK1 83 12
CHK1 101 8
CHK2 108 11
GSK3 beta 128 19
CDK2-Cyclin A 96 2
CDK9-Cyclin T1 109 1
PLK1 98 9
Aurora A 100 6
Aurora B 113 6
TLK1 107 11
LKB1 107 10
AMPK 104 2
AMPK (hum) 103 14
MARK1 123 0
MARK2 105 22
MARK3 112 7
MARK4 95 3
BRSK1 104 6
BRSK2 100 5
MELK 94 7
NUAK1 101 3
SIK2 114 9
SIK3 105 10
TSSK1 99 6
CK1 gamma 2 94 10
CK1 delta 99 5
CK2 105 1
TTBK1 104 24
TTBK2 93 3
DYRK1A 106 0
DYRK2 99 2
DYRK3 103 2
NEK2a 108 4
NEK6 111 4
IKK beta 92 8
IKK epsilon 122 5
TBK1 99 8
PIM1 101 8
PIM2 90 16
PIM3 90 9
SRPK1 105 13
EF2K 124 8
EIF2AK3 110 13
HIPK1 101 3
HIPK2 109 10
HIPK3 110 1
CLK2 100 9
PAK2 104 5
PAK4 108 6
PAK5 96 7
PAK6 91 13
MST2 134 4
MST3 128 14
MST4 108 1
GCK 114 23
MAP4K3 138 20
MAP4K5 114 9
MINK1 143 7
MEKK1 119 5
MLK1 110 2
MLK3 92 1
TESK1 110 24
TAO1 103 31
ASK1 100 5
TAK1 115 12
IRAK1 100 10
IRAK4 84 4
RIPK2 90 5
OSR1 110 7
TTK 104 0
MPSK1 103 8
WNK1 98 9
ULK1 122 11
ULK2 105 7
TGFBR1 99 9
Src 74 13
Lck 119 1
CSK 104 1
YES1 112 27
ABL 103 3
BTK 132 15
JAK2 117 3
SYK 112 2
ZAP70 112 22
TIE2 96 18
BRK 82 12
EPH-A2 99 3
EPH-A4 99 6
EPH-B1 124 5
EPH-B2 118 34
EPH-B3 117 11
EPH-B4 121 14
FGF-R1 117 6
HER4 104 1
IGF-1R 130 21
IR 109 21
IRR 97 9
TrkA 87 4
DDR2 116 1
VEGFR1 93 13
PDGFRA 114 7
PINK 87 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 103 3
MKK2 101 5
MKK6 92 7
ERK1 102 2
ERK2 94 15
ERK5 102 11
JNK1 88 2
JNK2 108 10
JNK3 96 7
p38 alpha MAPK 106 11
p38 beta MAPK 106 19
p38 gamma MAPK 108 4
p38 delta MAPK 95 7
ERK8 85 12
RSK1 114 2
RSK2 115 13
PDK1 91 3
PKB alpha 102 3
PKB beta 126 7
SGK1 104 3
S6K1 95 2
PKA 97 0
ROCK 2 105 7
PRK2 108 4
PKC alpha 98 3
PKC gamma 107 3
PKC zeta 101 1
PKD1 122 11
STK33 106 17
MSK1 92 8
MNK1 100 11
MNK2 106 11
MAPKAP-K2 87 3
MAPKAP-K3 98 3
PRAK 80 13
CAMKK beta 88 4
CAMK1 100 8
SmMLCK 118 6
PHK 87 9
DAPK1 83 7
CHK1 104 1
CHK2 105 11
GSK3 beta 116 5
CDK2-Cyclin A 112 2
CDK9-Cyclin T1 101 0
PLK1 103 2
Aurora A 91 0
Aurora B 101 9
TLK1 94 1
LKB1 94 15
AMPK 96 4
AMPK (hum) 109 7
MARK1 109 35
MARK2 104 3
MARK3 122 5
MARK4 105 2
BRSK1 89 6
BRSK2 95 1
MELK 100 6
NUAK1 103 5
SIK2 102 8
SIK3 99 10
TSSK1 97 2
CK1 gamma 2 113 17
CK1 delta 91 1
CK2 107 0
TTBK1 98 1
TTBK2 110 0
DYRK1A 94 8
DYRK2 99 9
DYRK3 103 17
NEK2a 102 7
NEK6 108 12
IKK beta 105 17
IKK epsilon 132 2
TBK1 100 4
PIM1 91 5
PIM2 92 21
PIM3 102 2
SRPK1 110 10
EF2K 124 13
EIF2AK3 108 7
HIPK1 117 1
HIPK2 118 2
HIPK3 85 4
CLK2 105 16
PAK2 105 15
PAK4 99 11
PAK5 89 6
PAK6 104 1
MST2 134 5
MST3 95 7
MST4 119 6
GCK 106 1
MAP4K3 101 6
MAP4K5 126 30
MINK1 121 14
MEKK1 109 7
MLK1 108 7
MLK3 91 6
TESK1 116 22
TAO1 106 6
ASK1 104 4
TAK1 115 8
IRAK1 99 13
IRAK4 93 10
RIPK2 95 2
OSR1 119 24
TTK 98 2
MPSK1 98 9
WNK1 102 7
ULK1 122 25
ULK2 102 8
TGFBR1 111 10
Src 135 9
Lck 121 14
CSK 98 2
YES1 91 3
ABL 101 1
BTK 125 8
JAK2 107 26
SYK 108 0
ZAP70 115 5
TIE2 96 4
BRK 78 7
EPH-A2 105 8
EPH-A4 114 19
EPH-B1 127 12
EPH-B2 116 8
EPH-B3 109 3
EPH-B4 115 16
FGF-R1 127 2
HER4 129 3
IGF-1R 113 20
IR 89 2
IRR 97 4
TrkA 98 9
DDR2 107 3
VEGFR1 99 18
PDGFRA 105 18
PINK 102 30

Do you need any help? Please get in touch and we’ll be happy to lend a hand.