Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MRT199665 C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91 WO2009152027 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
DDR2 1 0
AMPK 1 0
MARK3 1 0
MARK4 1 0
NUAK1 2 0
AMPK (hum) 2 0
FGF-R1 2 0
SIK2 3 0
IGF-1R 3 1
CLK2 4 0
MELK 5 3
SIK3 5 0
EPH-A2 5 2
EPH-B1 5 1
ULK2 5 3
Src 5 1
IR 5 2
JAK2 5 1
MLK1 6 1
CSK 6 3
EPH-A4 7 2
Aurora B 7 0
MLK3 7 1
Lck 7 5
TAK1 7 1
PKD1 8 3
MARK2 8 2
YES1 8 3
TrkA 8 2
VEGFR1 9 0
MST4 11 1
EPH-B4 11 1
TIE2 12 2
STK33 12 1
MST2 13 2
Aurora A 14 2
BTK 14 2
RSK1 15 0
CAMKK beta 15 3
PHK 15 4
TSSK1 17 2
MST3 18 0
EPH-B2 18 3
ERK8 19 0
ULK1 20 1
CDK2-Cyclin A 21 3
PDK1 21 2
MARK1 21 10
RSK2 22 1
IKK epsilon 23 3
MAP4K3 23 3
CHK1 25 4
PDGFRA 28 9
PAK5 31 0
OSR1 32 3
CDK9-Cyclin T1 34 13
ABL 34 0
PRK2 35 3
ERK2 39 2
TTK 40 2
MAP4K5 40 13
PAK4 40 0
MSK1 41 10
TAO1 43 3
IRAK4 47 3
DYRK1A 49 13
IRR 50 1
SGK1 51 2
PAK2 51 0
PAK6 55 1
CHK2 56 13
JNK2 56 7
SYK 57 7
HIPK2 59 2
GSK3 beta 60 5
ROCK 2 60 3
GCK 61 14
CAMK1 61 13
PKA 62 15
TBK1 64 15
ERK5 64 4
JNK3 67 9
SmMLCK 68 8
CK2 69 3
PKC zeta 72 10
EF2K 72 16
MINK1 73 0
DAPK1 73 4
CK1 delta 76 15
p38 beta MAPK 77 13
p38 delta MAPK 77 2
S6K1 77 15
ERK1 78 1
IKK beta 80 2
PRAK 80 0
PKB beta 81 1
HIPK1 81 15
PLK1 82 9
EPH-B3 82 10
MKK6 83 3
BRK 84 12
CK1 gamma 2 84 15
TESK1 84 8
NEK2a 84 5
MAPKAP-K2 85 22
JNK1 85 0
ASK1 85 11
PKC alpha 85 5
MNK2 86 6
NEK6 86 10
BRSK2 87 15
WNK1 87 8
RIPK2 88 31
LKB1 88 3
BRSK1 88 11
p38 alpha MAPK 89 18
MAPKAP-K3 89 20
IRAK1 89 7
EIF2AK3 90 9
SRPK1 93 0
MPSK1 94 1
PKB alpha 95 5
DYRK2 95 5
DYRK3 95 1
TTBK2 97 5
ZAP70 98 3
HIPK3 98 0
HER4 98 2
PIM1 99 12
MNK1 99 5
TTBK1 100 18
PKC gamma 101 3
p38 gamma MAPK 101 2
TLK1 102 5
PIM2 104 2
MEKK1 107 9
PIM3 109 14
MKK1 117 43
TGFBR1 122 28
MKK2 127 31
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
MARK3 2 0
MARK4 3 0
NUAK1 3 2
MLK1 5 0
AMPK (hum) 5 0
AMPK 7 0
MLK3 8 2
IR 8 3
DDR2 8 0
MELK 8 1
SIK2 8 2
Lck 10 3
MARK2 12 3
IGF-1R 12 0
PKD1 16 1
SIK3 19 2
FGF-R1 19 4
ULK2 20 0
JAK2 22 5
Src 23 0
MARK1 25 7
CLK2 25 1
VEGFR1 25 2
EPH-A4 26 5
EPH-A2 27 8
TrkA 33 1
EPH-B1 34 3
Aurora B 35 1
CAMKK beta 35 1
STK33 35 5
YES1 36 3
PHK 40 11
TAK1 43 12
BTK 44 2
ERK8 46 3
MST2 46 4
MST4 46 4
ULK1 52 6
PDGFRA 53 4
TTK 56 4
MST3 57 7
CDK2-Cyclin A 58 0
TIE2 59 8
RSK1 60 1
RSK2 61 0
PDK1 61 11
Aurora A 66 9
EF2K 66 11
HIPK2 67 7
IKK epsilon 67 15
CHK1 69 2
PRK2 70 4
EPH-B4 71 1
IKK beta 71 10
CSK 75 5
OSR1 75 0
TSSK1 76 21
PAK4 76 1
p38 delta MAPK 76 5
MAP4K5 77 9
PAK5 77 0
ABL 78 7
CDK9-Cyclin T1 78 4
PLK1 79 9
ERK2 79 8
CAMK1 79 6
TAO1 79 9
IRAK1 79 4
CK1 gamma 2 80 2
SGK1 80 10
IRR 80 2
MSK1 81 10
PKB alpha 81 3
PRAK 83 2
EIF2AK3 85 5
TBK1 85 8
GCK 87 8
PKB beta 87 1
ERK5 87 4
PKC zeta 87 8
GSK3 beta 88 7
MAP4K3 89 14
MNK2 89 2
JNK2 89 9
DAPK1 89 2
CHK2 89 16
DYRK3 90 5
ASK1 90 18
DYRK1A 91 8
SmMLCK 91 5
NEK6 91 12
MAPKAP-K2 92 4
MAPKAP-K3 92 9
PKA 92 7
ROCK 2 92 7
NEK2a 92 12
CK2 93 4
MINK1 94 2
EPH-B2 94 8
MKK2 94 3
HER4 94 4
MPSK1 95 3
MKK6 95 2
HIPK1 95 17
SYK 95 8
p38 beta MAPK 95 4
WNK1 96 3
PAK2 96 8
PAK6 96 7
RIPK2 96 17
TESK1 97 10
DYRK2 97 13
TTBK1 98 2
JNK1 98 7
ZAP70 98 5
TLK1 99 1
LKB1 99 6
EPH-B3 100 8
ERK1 100 1
JNK3 100 21
PKC alpha 100 17
p38 alpha MAPK 100 6
p38 gamma MAPK 100 3
IRAK4 101 6
PKC gamma 102 1
PIM2 103 0
MNK1 103 10
SRPK1 103 11
HIPK3 103 6
BRSK2 103 3
BRK 103 9
TTBK2 104 11
S6K1 104 8
PIM1 105 3
BRSK1 107 15
MEKK1 108 3
CK1 delta 109 4
PIM3 116 11
TGFBR1 119 10
MKK1 120 10

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