Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MRT199665 C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91 WO2009152027 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 117 43
MKK2 127 31
MKK6 83 3
ERK1 78 1
ERK2 39 2
ERK5 64 4
JNK1 85 0
JNK2 56 7
JNK3 67 9
p38 alpha MAPK 89 18
p38 beta MAPK 77 13
p38 gamma MAPK 101 2
p38 delta MAPK 77 2
ERK8 19 0
RSK1 15 0
RSK2 22 1
PDK1 21 2
PKB alpha 95 5
PKB beta 81 1
SGK1 51 2
S6K1 77 15
PKA 62 15
ROCK 2 60 3
PRK2 35 3
PKC alpha 85 5
PKC gamma 101 3
PKC zeta 72 10
PKD1 8 3
STK33 12 1
MSK1 41 10
MNK1 99 5
MNK2 86 6
MAPKAP-K2 85 22
MAPKAP-K3 89 20
PRAK 80 0
CAMKK beta 15 3
CAMK1 61 13
SmMLCK 68 8
PHK 15 4
DAPK1 73 4
CHK1 25 4
CHK2 56 13
GSK3 beta 60 5
CDK2-Cyclin A 21 3
CDK9-Cyclin T1 34 13
PLK1 82 9
Aurora A 14 2
Aurora B 7 0
TLK1 102 5
LKB1 88 3
AMPK 1 0
AMPK (hum) 2 0
MARK1 21 10
MARK2 8 2
MARK3 1 0
MARK4 1 0
BRSK1 88 11
BRSK2 87 15
MELK 5 3
NUAK1 2 0
SIK2 3 0
SIK3 5 0
TSSK1 17 2
CK1 gamma 2 84 15
CK1 delta 76 15
CK2 69 3
TTBK1 100 18
TTBK2 97 5
DYRK1A 49 13
DYRK2 95 5
DYRK3 95 1
NEK2a 84 5
NEK6 86 10
IKK beta 80 2
IKK epsilon 23 3
TBK1 64 15
PIM1 99 12
PIM2 104 2
PIM3 109 14
SRPK1 93 0
EF2K 72 16
EIF2AK3 90 9
HIPK1 81 15
HIPK2 59 2
HIPK3 98 0
CLK2 4 0
PAK2 51 0
PAK4 40 0
PAK5 31 0
PAK6 55 1
MST2 13 2
MST3 18 0
MST4 11 1
GCK 61 14
MAP4K3 23 3
MAP4K5 40 13
MINK1 73 0
MEKK1 107 9
MLK1 6 1
MLK3 7 1
TESK1 84 8
TAO1 43 3
ASK1 85 11
TAK1 7 1
IRAK1 89 7
IRAK4 47 3
RIPK2 88 31
OSR1 32 3
TTK 40 2
MPSK1 94 1
WNK1 87 8
ULK1 20 1
ULK2 5 3
TGFBR1 122 28
Src 5 1
Lck 7 5
CSK 6 3
YES1 8 3
ABL 34 0
BTK 14 2
JAK2 5 1
SYK 57 7
ZAP70 98 3
TIE2 12 2
BRK 84 12
EPH-A2 5 2
EPH-A4 7 2
EPH-B1 5 1
EPH-B2 18 3
EPH-B3 82 10
EPH-B4 11 1
FGF-R1 2 0
HER4 98 2
IGF-1R 3 1
IR 5 2
IRR 50 1
TrkA 8 2
DDR2 1 0
VEGFR1 9 0
PDGFRA 28 9
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 120 10
MKK2 94 3
MKK6 95 2
ERK1 100 1
ERK2 79 8
ERK5 87 4
JNK1 98 7
JNK2 89 9
JNK3 100 21
p38 alpha MAPK 100 6
p38 beta MAPK 95 4
p38 gamma MAPK 100 3
p38 delta MAPK 76 5
ERK8 46 3
RSK1 60 1
RSK2 61 0
PDK1 61 11
PKB alpha 81 3
PKB beta 87 1
SGK1 80 10
S6K1 104 8
PKA 92 7
ROCK 2 92 7
PRK2 70 4
PKC alpha 100 17
PKC gamma 102 1
PKC zeta 87 8
PKD1 16 1
STK33 35 5
MSK1 81 10
MNK1 103 10
MNK2 89 2
MAPKAP-K2 92 4
MAPKAP-K3 92 9
PRAK 83 2
CAMKK beta 35 1
CAMK1 79 6
SmMLCK 91 5
PHK 40 11
DAPK1 89 2
CHK1 69 2
CHK2 89 16
GSK3 beta 88 7
CDK2-Cyclin A 58 0
CDK9-Cyclin T1 78 4
PLK1 79 9
Aurora A 66 9
Aurora B 35 1
TLK1 99 1
LKB1 99 6
AMPK 7 0
AMPK (hum) 5 0
MARK1 25 7
MARK2 12 3
MARK3 2 0
MARK4 3 0
BRSK1 107 15
BRSK2 103 3
MELK 8 1
NUAK1 3 2
SIK2 8 2
SIK3 19 2
TSSK1 76 21
CK1 gamma 2 80 2
CK1 delta 109 4
CK2 93 4
TTBK1 98 2
TTBK2 104 11
DYRK1A 91 8
DYRK2 97 13
DYRK3 90 5
NEK2a 92 12
NEK6 91 12
IKK beta 71 10
IKK epsilon 67 15
TBK1 85 8
PIM1 105 3
PIM2 103 0
PIM3 116 11
SRPK1 103 11
EF2K 66 11
EIF2AK3 85 5
HIPK1 95 17
HIPK2 67 7
HIPK3 103 6
CLK2 25 1
PAK2 96 8
PAK4 76 1
PAK5 77 0
PAK6 96 7
MST2 46 4
MST3 57 7
MST4 46 4
GCK 87 8
MAP4K3 89 14
MAP4K5 77 9
MINK1 94 2
MEKK1 108 3
MLK1 5 0
MLK3 8 2
TESK1 97 10
TAO1 79 9
ASK1 90 18
TAK1 43 12
IRAK1 79 4
IRAK4 101 6
RIPK2 96 17
OSR1 75 0
TTK 56 4
MPSK1 95 3
WNK1 96 3
ULK1 52 6
ULK2 20 0
TGFBR1 119 10
Src 23 0
Lck 10 3
CSK 75 5
YES1 36 3
ABL 78 7
BTK 44 2
JAK2 22 5
SYK 95 8
ZAP70 98 5
TIE2 59 8
BRK 103 9
EPH-A2 27 8
EPH-A4 26 5
EPH-B1 34 3
EPH-B2 94 8
EPH-B3 100 8
EPH-B4 71 1
FGF-R1 19 4
HER4 94 4
IGF-1R 12 0
IR 8 3
IRR 80 2
TrkA 33 1
DDR2 8 0
VEGFR1 25 2
PDGFRA 53 4

Do you need any help? Please get in touch and we’ll be happy to lend a hand.