Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PKR Inhibitor C13H8N4OS 268.3 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8 Sigma Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 0
MKK2 2 0
MKK6 20 6
ERK1 1 0
ERK2 8 4
ERK5 9 3
JNK1 34 1
JNK2 41 4
JNK3 48 13
p38 alpha MAPK 82 4
p38 beta MAPK 65 2
p38 gamma MAPK 26 2
p38 delta MAPK 57 9
ERK8 3 1
RSK1 13 2
RSK2 18 0
PDK1 25 0
PKB alpha 85 2
PKB beta 69 10
SGK1 12 1
S6K1 36 8
PKA 39 2
ROCK 2 5 1
PRK2 2 0
PKC alpha 54 4
PKC gamma 82 8
PKC zeta 48 5
PKD1 6 1
STK33 30 1
MSK1 13 2
MNK1 4 1
MNK2 13 2
MAPKAP-K2 72 3
MAPKAP-K3 95 2
PRAK 67 3
CAMKK beta 33 8
CAMK1 66 4
SmMLCK 19 2
PHK 21 1
DAPK1 39 3
CHK1 16 2
CHK2 38 2
GSK3 beta 2 0
CDK2-Cyclin A 5 1
CDK9-Cyclin T1 11 0
PLK1 66 10
Aurora A 12 0
Aurora B 4 1
TLK1 52 8
LKB1 67 3
AMPK 5 2
AMPK (hum) 3 0
MARK1 9 1
MARK2 11 3
MARK3 7 1
MARK4 11 0
BRSK1 3 0
BRSK2 6 2
MELK 6 1
NUAK1 2 1
SIK2 20 6
SIK3 23 3
TSSK1 46 6
CK1 gamma 2 55 9
CK1 delta 19 5
CK2 23 5
TTBK1 77 12
TTBK2 82 6
DYRK1A 3 1
DYRK2 4 1
DYRK3 7 1
NEK2a 70 0
NEK6 67 8
IKK beta 35 4
IKK epsilon 8 4
TBK1 7 0
PIM1 11 2
PIM2 17 2
PIM3 58 12
SRPK1 88 15
EF2K 87 13
EIF2AK3 62 3
HIPK1 47 2
HIPK2 14 1
HIPK3 37 2
CLK2 2 1
PAK2 86 3
PAK4 45 3
PAK5 62 4
PAK6 80 10
MST2 4 1
MST3 12 1
MST4 47 9
GCK 4 1
MAP4K3 -1 2
MAP4K5 4 5
MINK1 4 0
MEKK1 81 1
MLK1 11 3
MLK3 6 0
TESK1 75 2
TAO1 15 3
ASK1 15 0
TAK1 4 0
IRAK1 6 1
IRAK4 26 2
RIPK2 46 1
OSR1 58 0
TTK 29 1
MPSK1 86 2
WNK1 89 17
ULK1 12 2
ULK2 13 1
TGFBR1 93 7
Src 46 9
Lck 58 4
CSK 98 7
YES1 69 7
ABL 71 3
BTK 57 7
JAK2 12 1
SYK 71 4
ZAP70 97 2
TIE2 66 8
BRK 68 9
EPH-A2 46 4
EPH-A4 63 4
EPH-B1 66 10
EPH-B2 64 3
EPH-B3 75 28
EPH-B4 62 2
FGF-R1 27 1
HER4 75 15
IGF-1R 54 6
IR 57 3
IRR 23 1
TrkA 6 1
DDR2 62 6
VEGFR1 3 1
PDGFRA 25 2
PINK 111 16
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 0 0
MKK2 1 0
MKK6 12 3
ERK1 1 2
ERK2 3 2
ERK5 4 0
JNK1 9 0
JNK2 12 1
JNK3 12 1
p38 alpha MAPK 65 9
p38 beta MAPK 24 2
p38 gamma MAPK 11 1
p38 delta MAPK 17 1
ERK8 3 1
RSK1 4 0
RSK2 6 0
PDK1 8 0
PKB alpha 32 1
PKB beta 58 22
SGK1 10 9
S6K1 12 1
PKA 10 0
ROCK 2 2 1
PRK2 2 0
PKC alpha 25 3
PKC gamma 38 3
PKC zeta 21 1
PKD1 3 1
STK33 10 1
MSK1 4 2
MNK1 2 1
MNK2 2 1
MAPKAP-K2 42 6
MAPKAP-K3 85 12
PRAK 26 5
CAMKK beta 10 0
CAMK1 24 2
SmMLCK 5 1
PHK 4 0
DAPK1 10 0
CHK1 4 0
CHK2 10 1
GSK3 beta 4 3
CDK2-Cyclin A 5 2
CDK9-Cyclin T1 2 2
PLK1 27 0
Aurora A 3 0
Aurora B 1 1
TLK1 20 2
LKB1 43 0
AMPK 1 0
AMPK (hum) 1 0
MARK1 1 0
MARK2 2 0
MARK3 4 3
MARK4 3 1
BRSK1 1 0
BRSK2 2 1
MELK 3 0
NUAK1 1 0
SIK2 4 0
SIK3 4 1
TSSK1 15 1
CK1 gamma 2 24 4
CK1 delta 4 0
CK2 5 0
TTBK1 66 6
TTBK2 75 14
DYRK1A 1 0
DYRK2 1 0
DYRK3 2 1
NEK2a 16 1
NEK6 56 13
IKK beta 14 1
IKK epsilon 1 0
TBK1 5 2
PIM1 5 4
PIM2 4 0
PIM3 2 1
SRPK1 81 6
EF2K 52 7
EIF2AK3 25 3
HIPK1 10 1
HIPK2 3 0
HIPK3 11 2
CLK2 0 0
PAK2 60 9
PAK4 15 4
PAK5 28 8
PAK6 33 3
MST2 3 1
MST3 20 24
MST4 2 1
GCK 1 1
MAP4K3 -1 3
MAP4K5 -1 4
MINK1 1 0
MEKK1 63 1
MLK1 2 0
MLK3 2 1
TESK1 42 5
TAO1 4 1
ASK1 3 2
TAK1 1 0
IRAK1 6 1
IRAK4 8 0
RIPK2 15 1
OSR1 17 5
TTK 15 1
MPSK1 65 17
WNK1 91 3
ULK1 4 0
ULK2 3 0
TGFBR1 63 5
Src 12 0
Lck 15 0
CSK 61 6
YES1 34 4
ABL 25 3
BTK 11 13
JAK2 4 2
SYK 30 3
ZAP70 98 10
TIE2 25 2
BRK 25 2
EPH-A2 17 2
EPH-A4 32 2
EPH-B1 25 2
EPH-B2 22 1
EPH-B3 20 7
EPH-B4 27 2
FGF-R1 8 5
HER4 41 12
IGF-1R 4 1
IR 8 1
IRR 9 0
TrkA 2 1
DDR2 23 1
VEGFR1 2 0
PDGFRA 12 3
PINK 96 14

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