Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Genentech LRRK2 inhibitor compound 19 C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
TAK1 2 0
IR 3 0
CHK2 3 0
CLK2 5 2
TSSK1 7 0
MLK1 7 0
SmMLCK 8 2
IGF-1R 8 1
PHK 8 0
NUAK1 9 1
MLK3 9 1
DYRK2 9 2
PKD1 10 3
CAMKK beta 10 1
DAPK1 11 4
ASK1 13 1
VEGFR1 14 1
RSK1 14 1
BRK 22 3
MNK2 22 4
Aurora B 24 2
GCK 25 6
RSK2 25 7
CHK1 25 0
TBK1 26 5
MNK1 26 0
ERK8 28 3
HIPK2 28 9
STK33 30 8
TTK 31 8
MKK6 31 2
SIK2 34 12
MAP4K3 36 0
DYRK1A 38 6
MELK 39 3
PLK1 40 6
ERK5 42 3
PAK4 42 7
GSK3 beta 43 1
AMPK (hum) 44 17
SYK 44 11
JNK1 47 6
JNK3 48 1
PRAK 49 3
HIPK1 49 5
ERK1 49 5
OSR1 51 1
CAMK1 51 4
DYRK3 51 9
BRSK2 51 0
MARK4 52 4
JAK2 52 3
TrkA 54 12
IKK epsilon 55 8
ERK2 55 2
ULK1 56 2
MARK3 61 6
MSK1 65 7
HER4 65 5
CK1 delta 67 2
IRR 67 6
S6K1 68 2
SRPK1 69 5
BRSK1 69 11
ULK2 70 1
AMPK 70 11
SGK1 70 7
HIPK3 70 20
CDK2-Cyclin A 72 6
NEK2a 72 19
CK2 74 7
PDGFRA 76 4
PIM3 78 0
ROCK 2 78 1
RIPK2 79 2
p38 delta MAPK 79 20
PAK5 79 1
TAO1 80 3
Aurora A 81 13
MKK1 81 7
Src 81 0
MARK2 81 1
EIF2AK3 82 3
PRK2 82 6
JNK2 84 6
MST3 85 2
MARK1 85 18
PKC zeta 86 3
ZAP70 86 1
MST4 87 4
PDK1 88 7
PAK2 88 2
CK1 gamma 2 89 5
IKK beta 89 4
CDK9-Cyclin T1 90 10
NEK6 90 6
TIE2 91 5
MAP4K5 91 2
EPH-B1 91 14
MST2 92 3
LKB1 92 7
SIK3 93 9
EPH-A2 93 6
TTBK1 93 6
IRAK4 93 9
PIM1 94 3
EPH-B4 94 3
IRAK1 94 4
PAK6 94 6
p38 gamma MAPK 96 3
TLK1 96 8
MAPKAP-K2 97 3
EPH-B2 97 3
PKB alpha 97 6
TTBK2 97 13
ABL 97 10
EPH-A4 98 6
MKK2 98 6
PKB beta 98 3
BTK 98 24
PKC gamma 98 21
DDR2 100 8
p38 beta MAPK 101 10
MPSK1 101 14
CSK 101 12
PKC alpha 101 2
Lck 102 15
TGFBR1 103 3
FGF-R1 104 6
EPH-B3 105 11
WNK1 106 5
PIM2 107 6
EF2K 107 1
PKA 107 22
MINK1 109 12
MEKK1 109 15
YES1 110 8
TESK1 118 3
p38 alpha MAPK 119 2
MAPKAP-K3 124 9
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
TAK1 11 2
CHK2 18 1
TSSK1 31 4
MLK3 35 4
IGF-1R 35 1
CLK2 36 1
MLK1 39 11
CAMKK beta 40 8
DYRK2 40 7
PKD1 41 7
NUAK1 41 4
SmMLCK 44 6
PHK 45 11
STK33 47 3
IR 50 4
DAPK1 53 9
BRK 53 0
RSK1 54 6
VEGFR1 55 3
TTK 56 7
TBK1 57 22
CHK1 58 1
MNK2 58 2
ASK1 66 8
ERK5 66 1
Aurora B 68 8
TrkA 70 8
HIPK2 70 8
MKK6 71 0
GSK3 beta 73 19
GCK 73 0
MNK1 74 5
HER4 74 5
MAP4K3 76 10
RSK2 77 1
PRAK 77 9
PLK1 78 5
DYRK1A 78 5
JAK2 79 1
ERK1 79 8
JNK3 80 2
PDGFRA 81 9
ERK8 81 4
EPH-A2 81 17
AMPK (hum) 82 12
JNK1 83 7
PRK2 84 9
IRR 84 3
p38 alpha MAPK 84 9
SIK2 84 10
SRPK1 84 4
PAK4 85 9
BRSK1 85 1
TIE2 85 5
MSK1 85 2
EPH-A4 86 7
SYK 87 24
CDK9-Cyclin T1 87 3
EIF2AK3 87 4
DYRK3 88 6
BRSK2 88 5
ZAP70 88 6
ULK2 88 5
LKB1 88 7
SGK1 88 13
MARK1 88 4
PAK2 89 3
MST4 89 5
S6K1 89 1
YES1 89 7
IRAK4 90 6
CK1 gamma 2 90 6
MEKK1 90 9
MARK3 91 9
MELK 91 10
EPH-B3 91 5
TTBK2 91 7
EPH-B2 92 8
AMPK 92 20
HIPK1 92 1
CAMK1 92 8
EPH-B1 93 4
PKB alpha 93 3
PAK5 94 1
PAK6 94 10
IKK epsilon 94 7
RIPK2 94 8
CDK2-Cyclin A 94 14
EPH-B4 94 0
ROCK 2 95 2
MARK4 95 5
OSR1 95 1
SIK3 95 3
MKK1 95 0
CK1 delta 95 1
ERK2 95 7
PKC alpha 96 3
MST3 96 8
CK2 96 15
TTBK1 96 5
NEK2a 97 7
IKK beta 97 10
p38 delta MAPK 97 6
WNK1 97 0
FGF-R1 97 10
IRAK1 98 2
p38 beta MAPK 98 9
p38 gamma MAPK 98 1
ULK1 98 7
TGFBR1 99 0
PKB beta 99 4
TAO1 99 6
PKC gamma 100 25
PIM2 100 1
MARK2 100 12
PKC zeta 101 2
PIM1 101 1
PIM3 101 0
HIPK3 101 5
MAPKAP-K2 102 2
TESK1 102 4
CSK 102 17
PKA 102 10
EF2K 103 0
PDK1 104 16
Lck 104 23
DDR2 105 9
Aurora A 105 12
ABL 106 18
TLK1 106 5
MAP4K5 107 9
Src 107 19
JNK2 108 3
MAPKAP-K3 108 5
MST2 111 13
NEK6 112 1
BTK 115 11
MPSK1 115 16
MKK2 118 2
MINK1 124 9

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