Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Genentech LRRK2 inhibitor compound 19 C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 7
MKK2 98 6
MKK6 31 2
ERK1 49 5
ERK2 55 2
ERK5 42 3
JNK1 47 6
JNK2 84 6
JNK3 48 1
p38 alpha MAPK 119 2
p38 beta MAPK 101 10
p38 gamma MAPK 96 3
p38 delta MAPK 79 20
ERK8 28 3
RSK1 14 1
RSK2 25 7
PDK1 88 7
PKB alpha 97 6
PKB beta 98 3
SGK1 70 7
S6K1 68 2
PKA 107 22
ROCK 2 78 1
PRK2 82 6
PKC alpha 101 2
PKC gamma 98 21
PKC zeta 86 3
PKD1 10 3
STK33 30 8
MSK1 65 7
MNK1 26 0
MNK2 22 4
MAPKAP-K2 97 3
MAPKAP-K3 124 9
PRAK 49 3
CAMKK beta 10 1
CAMK1 51 4
SmMLCK 8 2
PHK 8 0
DAPK1 11 4
CHK1 25 0
CHK2 3 0
GSK3 beta 43 1
CDK2-Cyclin A 72 6
CDK9-Cyclin T1 90 10
PLK1 40 6
Aurora A 81 13
Aurora B 24 2
TLK1 96 8
LKB1 92 7
AMPK 70 11
AMPK (hum) 44 17
MARK1 85 18
MARK2 81 1
MARK3 61 6
MARK4 52 4
BRSK1 69 11
BRSK2 51 0
MELK 39 3
NUAK1 9 1
SIK2 34 12
SIK3 93 9
TSSK1 7 0
CK1 gamma 2 89 5
CK1 delta 67 2
CK2 74 7
TTBK1 93 6
TTBK2 97 13
DYRK1A 38 6
DYRK2 9 2
DYRK3 51 9
NEK2a 72 19
NEK6 90 6
IKK beta 89 4
IKK epsilon 55 8
TBK1 26 5
PIM1 94 3
PIM2 107 6
PIM3 78 0
SRPK1 69 5
EF2K 107 1
EIF2AK3 82 3
HIPK1 49 5
HIPK2 28 9
HIPK3 70 20
CLK2 5 2
PAK2 88 2
PAK4 42 7
PAK5 79 1
PAK6 94 6
MST2 92 3
MST3 85 2
MST4 87 4
GCK 25 6
MAP4K3 36 0
MAP4K5 91 2
MINK1 109 12
MEKK1 109 15
MLK1 7 0
MLK3 9 1
TESK1 118 3
TAO1 80 3
ASK1 13 1
TAK1 2 0
IRAK1 94 4
IRAK4 93 9
RIPK2 79 2
OSR1 51 1
TTK 31 8
MPSK1 101 14
WNK1 106 5
ULK1 56 2
ULK2 70 1
TGFBR1 103 3
Src 81 0
Lck 102 15
CSK 101 12
YES1 110 8
ABL 97 10
BTK 98 24
JAK2 52 3
SYK 44 11
ZAP70 86 1
TIE2 91 5
BRK 22 3
EPH-A2 93 6
EPH-A4 98 6
EPH-B1 91 14
EPH-B2 97 3
EPH-B3 105 11
EPH-B4 94 3
FGF-R1 104 6
HER4 65 5
IGF-1R 8 1
IR 3 0
IRR 67 6
TrkA 54 12
DDR2 100 8
VEGFR1 14 1
PDGFRA 76 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 0
MKK2 118 2
MKK6 71 0
ERK1 79 8
ERK2 95 7
ERK5 66 1
JNK1 83 7
JNK2 108 3
JNK3 80 2
p38 alpha MAPK 84 9
p38 beta MAPK 98 9
p38 gamma MAPK 98 1
p38 delta MAPK 97 6
ERK8 81 4
RSK1 54 6
RSK2 77 1
PDK1 104 16
PKB alpha 93 3
PKB beta 99 4
SGK1 88 13
S6K1 89 1
PKA 102 10
ROCK 2 95 2
PRK2 84 9
PKC alpha 96 3
PKC gamma 100 25
PKC zeta 101 2
PKD1 41 7
STK33 47 3
MSK1 85 2
MNK1 74 5
MNK2 58 2
MAPKAP-K2 102 2
MAPKAP-K3 108 5
PRAK 77 9
CAMKK beta 40 8
CAMK1 92 8
SmMLCK 44 6
PHK 45 11
DAPK1 53 9
CHK1 58 1
CHK2 18 1
GSK3 beta 73 19
CDK2-Cyclin A 94 14
CDK9-Cyclin T1 87 3
PLK1 78 5
Aurora A 105 12
Aurora B 68 8
TLK1 106 5
LKB1 88 7
AMPK 92 20
AMPK (hum) 82 12
MARK1 88 4
MARK2 100 12
MARK3 91 9
MARK4 95 5
BRSK1 85 1
BRSK2 88 5
MELK 91 10
NUAK1 41 4
SIK2 84 10
SIK3 95 3
TSSK1 31 4
CK1 gamma 2 90 6
CK1 delta 95 1
CK2 96 15
TTBK1 96 5
TTBK2 91 7
DYRK1A 78 5
DYRK2 40 7
DYRK3 88 6
NEK2a 97 7
NEK6 112 1
IKK beta 97 10
IKK epsilon 94 7
TBK1 57 22
PIM1 101 1
PIM2 100 1
PIM3 101 0
SRPK1 84 4
EF2K 103 0
EIF2AK3 87 4
HIPK1 92 1
HIPK2 70 8
HIPK3 101 5
CLK2 36 1
PAK2 89 3
PAK4 85 9
PAK5 94 1
PAK6 94 10
MST2 111 13
MST3 96 8
MST4 89 5
GCK 73 0
MAP4K3 76 10
MAP4K5 107 9
MINK1 124 9
MEKK1 90 9
MLK1 39 11
MLK3 35 4
TESK1 102 4
TAO1 99 6
ASK1 66 8
TAK1 11 2
IRAK1 98 2
IRAK4 90 6
RIPK2 94 8
OSR1 95 1
TTK 56 7
MPSK1 115 16
WNK1 97 0
ULK1 98 7
ULK2 88 5
TGFBR1 99 0
Src 107 19
Lck 104 23
CSK 102 17
YES1 89 7
ABL 106 18
BTK 115 11
JAK2 79 1
SYK 87 24
ZAP70 88 6
TIE2 85 5
BRK 53 0
EPH-A2 81 17
EPH-A4 86 7
EPH-B1 93 4
EPH-B2 92 8
EPH-B3 91 5
EPH-B4 94 0
FGF-R1 97 10
HER4 74 5
IGF-1R 35 1
IR 50 4
IRR 84 3
TrkA 70 8
DDR2 105 9
VEGFR1 55 3
PDGFRA 81 9

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