Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Genentech LRRK2 inhibitor compound 18 (GNE-7915) C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33 Download

Results as Barchart

View results as a bar chart
1µM
10µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 75 1
MKK2 90 5
MKK6 31 0
ERK1 54 3
ERK2 71 2
ERK5 32 2
JNK1 50 3
JNK2 89 1
JNK3 50 4
p38 alpha MAPK 101 4
p38 beta MAPK 91 4
p38 gamma MAPK 102 8
p38 delta MAPK 98 2
ERK8 78 8
RSK1 8 8
RSK2 9 4
PDK1 68 7
PKB alpha 87 3
PKB beta 95 10
SGK1 59 0
S6K1 60 0
PKA 86 33
ROCK 2 72 2
PRK2 65 4
PKC alpha 97 5
PKC gamma 95 6
PKC zeta 83 4
PKD1 11 0
STK33 22 4
MSK1 49 7
MNK1 45 1
MNK2 23 3
MAPKAP-K2 85 7
MAPKAP-K3 108 13
PRAK 55 4
CAMKK beta 7 2
CAMK1 27 2
SmMLCK 6 0
PHK 3 0
DAPK1 9 0
CHK1 12 1
CHK2 2 0
GSK3 beta 83 3
CDK2-Cyclin A 79 9
CDK9-Cyclin T1 90 7
PLK1 39 4
Aurora A 55 2
Aurora B 18 1
TLK1 101 14
LKB1 86 3
AMPK 56 2
AMPK (hum) 29 7
MARK1 58 0
MARK2 73 1
MARK3 41 1
MARK4 67 1
BRSK1 50 14
BRSK2 38 11
MELK 43 2
NUAK1 2 0
SIK2 21 2
SIK3 88 5
TSSK1 3 1
CK1 gamma 2 90 1
CK1 delta 81 7
CK2 82 7
TTBK1 84 6
TTBK2 74 12
DYRK1A 48 3
DYRK2 17 9
DYRK3 58 5
NEK2a 92 4
NEK6 84 8
IKK beta 93 3
IKK epsilon 23 3
TBK1 17 3
PIM1 99 14
PIM2 93 0
PIM3 76 5
SRPK1 68 0
EF2K 107 4
EIF2AK3 80 3
HIPK1 35 5
HIPK2 65 1
HIPK3 98 12
CLK2 9 0
PAK2 86 4
PAK4 32 1
PAK5 56 2
PAK6 93 1
MST2 73 9
MST3 81 9
MST4 74 3
GCK 28 1
MAP4K3 21 1
MAP4K5 90 10
MINK1 93 10
MEKK1 99 8
MLK1 3 0
MLK3 5 1
TESK1 98 2
TAO1 102 12
ASK1 10 4
TAK1 2 0
IRAK1 93 6
IRAK4 83 1
RIPK2 74 9
OSR1 54 6
TTK 32 7
MPSK1 96 15
WNK1 104 12
ULK1 47 8
ULK2 61 1
TGFBR1 102 4
Src 83 2
Lck 101 8
CSK 94 14
YES1 104 14
ABL 106 4
BTK 90 3
JAK2 35 2
SYK 33 4
ZAP70 79 3
TIE2 85 10
BRK 15 2
EPH-A2 86 1
EPH-A4 76 4
EPH-B1 90 3
EPH-B2 100 3
EPH-B3 83 4
EPH-B4 87 3
FGF-R1 95 15
HER4 70 3
IGF-1R 38 2
IR 2 0
IRR 67 9
TrkA 63 18
DDR2 98 4
VEGFR1 13 2
PDGFRA 61 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 5
MKK2 93 14
MKK6 72 6
ERK1 85 3
ERK2 99 1
ERK5 65 0
JNK1 87 5
JNK2 104 1
JNK3 84 12
p38 alpha MAPK 89 6
p38 beta MAPK 98 10
p38 gamma MAPK 99 5
p38 delta MAPK 102 3
ERK8 96 2
RSK1 21 10
RSK2 34 5
PDK1 89 1
PKB alpha 102 9
PKB beta 92 12
SGK1 72 9
S6K1 89 2
PKA 96 2
ROCK 2 85 4
PRK2 73 3
PKC alpha 95 5
PKC gamma 108 5
PKC zeta 99 6
PKD1 46 5
STK33 39 4
MSK1 91 8
MNK1 92 11
MNK2 62 2
MAPKAP-K2 107 11
MAPKAP-K3 91 9
PRAK 80 14
CAMKK beta 28 4
CAMK1 74 5
SmMLCK 31 2
PHK 23 1
DAPK1 43 1
CHK1 44 3
CHK2 12 4
GSK3 beta 90 3
CDK2-Cyclin A 102 7
CDK9-Cyclin T1 96 11
PLK1 76 6
Aurora A 97 13
Aurora B 55 5
TLK1 104 1
LKB1 89 7
AMPK 75 9
AMPK (hum) 71 1
MARK1 97 5
MARK2 98 8
MARK3 80 4
MARK4 91 3
BRSK1 82 5
BRSK2 80 7
MELK 90 8
NUAK1 13 2
SIK2 66 3
SIK3 110 8
TSSK1 12 1
CK1 gamma 2 91 1
CK1 delta 98 7
CK2 95 3
TTBK1 100 2
TTBK2 95 13
DYRK1A 85 4
DYRK2 50 8
DYRK3 96 9
NEK2a 99 8
NEK6 103 3
IKK beta 91 16
IKK epsilon 78 6
TBK1 62 4
PIM1 94 6
PIM2 100 21
PIM3 105 4
SRPK1 79 9
EF2K 116 19
EIF2AK3 99 16
HIPK1 78 8
HIPK2 88 3
HIPK3 107 5
CLK2 50 5
PAK2 86 3
PAK4 92 8
PAK5 95 7
PAK6 107 5
MST2 85 8
MST3 97 7
MST4 86 8
GCK 88 1
MAP4K3 69 3
MAP4K5 109 9
MINK1 115 1
MEKK1 104 5
MLK1 25 4
MLK3 23 3
TESK1 104 15
TAO1 111 9
ASK1 44 10
TAK1 17 1
IRAK1 100 6
IRAK4 103 5
RIPK2 86 8
OSR1 99 6
TTK 52 3
MPSK1 97 8
WNK1 103 1
ULK1 98 9
ULK2 92 6
TGFBR1 110 1
Src 87 0
Lck 108 3
CSK 101 11
YES1 104 8
ABL 102 9
BTK 131 3
JAK2 72 7
SYK 70 18
ZAP70 102 2
TIE2 100 6
BRK 57 4
EPH-A2 107 8
EPH-A4 97 11
EPH-B1 100 5
EPH-B2 110 4
EPH-B3 106 21
EPH-B4 96 2
FGF-R1 118 7
HER4 97 6
IGF-1R 32 4
IR 19 2
IRR 90 2
TrkA 81 9
DDR2 97 11
VEGFR1 62 16
PDGFRA 91 16

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