Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
KIN 112 C32H36N6O4 568.67 Lck Martin M.W. (2006) J.Med.Chem. 49 4981-4991 Download

Results as Barchart

View results as a bar chart
0.01µM
0.1µM
1µM

Results as Table

Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 100 10
MKK2 99 27
MKK6 98 7
ERK1 101 1
ERK2 100 9
JNK1 92 18
JNK2 103 23
JNK3 103 27
p38 alpha MAPK 118 9
p38 beta MAPK 113 10
p38 gamma MAPK 103 5
p38 delta MAPK 97 14
ERK8 104 10
RSK1 95 10
RSK2 98 5
PDK1 97 5
PKB alpha 95 6
PKB beta 85 12
SGK1 93 7
S6K1 95 6
PKA 91 17
ROCK 2 99 13
PRK2 89 5
PKC alpha 97 8
PKC gamma 92 15
PKC zeta 99 9
PKD1 95 8
STK33 113 28
MSK1 90 8
MNK1 87 2
MNK2 100 7
MAPKAP-K2 95 5
MAPKAP-K3 99 30
PRAK 138 28
CAMKK beta 90 0
CAMK1 101 11
SmMLCK 97 5
PHK 108 22
DAPK1 85 3
CHK1 97 8
CHK2 94 10
GSK3 beta 96 5
CDK2-Cyclin A 115 14
CDK9-Cyclin T1 106 4
PLK1 94 1
Aurora A 98 2
Aurora B 96 7
TLK1 94 0
LKB1 110 7
AMPK 99 14
MARK1 82 2
MARK2 100 30
MARK3 89 3
MARK4 96 28
BRSK1 103 14
BRSK2 93 5
MELK 102 5
NUAK1 98 11
SIK2 58 4
SIK3 89 3
TSSK1 110 12
CK1 gamma 2 99 16
CK1 delta 86 3
CK2 99 6
TTBK1 93 2
DYRK1A 95 15
DYRK2 94 10
DYRK3 91 4
NEK2a 98 12
NEK6 82 11
IKK beta 86 4
IKK epsilon 99 13
TBK1 94 10
PIM1 106 2
PIM2 91 5
PIM3 102 2
SRPK1 86 9
EF2K 91 4
EIF2AK3 100 16
HIPK1 68 1
HIPK2 100 16
HIPK3 77 5
CLK2 110 1
PAK2 79 8
PAK4 101 5
PAK5 103 0
PAK6 103 1
MST2 113 29
MST3 83 30
MST4 105 10
GCK 98 11
MINK1 102 16
MEKK1 96 20
MLK1 87 17
MLK3 87 27
TESK1 80 6
TAO1 98 10
ASK1 106 20
TAK1 122 11
IRAK1 92 9
IRAK4 90 9
RIPK2 89 11
OSR1 104 18
TTK 99 1
MPSK1 109 10
WNK1 107 13
Src 45 8
Lck 57 6
CSK 117 15
YES1 52 5
ABL 90 0
BTK 87 11
JAK2 91 4
SYK 103 4
ZAP70 95 12
TIE2 125 3
BRK 83 4
EPH-A2 57 3
EPH-A4 58 5
EPH-B1 68 4
EPH-B2 104 1
EPH-B3 121 8
EPH-B4 101 5
FGF-R1 90 10
HER4 95 7
IGF-1R 126 0
IR 111 2
IRR 96 5
TrkA 91 11
DDR2 45 18
VEGFR1 89 13
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 93 1
MKK2 83 14
MKK6 104 3
ERK1 113 19
ERK2 103 2
JNK1 103 8
JNK2 92 1
JNK3 96 3
p38 alpha MAPK 115 1
p38 beta MAPK 99 9
p38 gamma MAPK 110 23
p38 delta MAPK 93 18
ERK8 92 6
RSK1 96 7
RSK2 97 2
PDK1 103 5
PKB alpha 94 2
PKB beta 75 8
SGK1 98 16
S6K1 92 13
PKA 75 8
ROCK 2 104 13
PRK2 92 22
PKC alpha 100 3
PKC gamma 102 5
PKC zeta 90 2
PKD1 83 17
STK33 99 12
MSK1 90 3
MNK1 99 6
MNK2 104 3
MAPKAP-K2 101 8
MAPKAP-K3 88 16
PRAK 116 2
CAMKK beta 84 2
CAMK1 92 7
SmMLCK 85 4
PHK 103 3
DAPK1 80 7
CHK1 94 8
CHK2 65 8
GSK3 beta 89 15
CDK2-Cyclin A 107 0
CDK9-Cyclin T1 90 4
PLK1 93 1
Aurora A 91 8
Aurora B 96 11
TLK1 89 10
LKB1 106 1
AMPK 88 4
MARK1 73 0
MARK2 90 5
MARK3 85 2
MARK4 101 8
BRSK1 103 3
BRSK2 108 8
MELK 100 5
NUAK1 88 7
SIK2 10 5
SIK3 37 9
TSSK1 99 25
CK1 gamma 2 85 1
CK1 delta 85 2
CK2 93 7
TTBK1 88 3
DYRK1A 101 10
DYRK2 88 9
DYRK3 91 17
NEK2a 101 20
NEK6 93 8
IKK beta 107 1
IKK epsilon 108 0
TBK1 86 2
PIM1 97 9
PIM2 88 31
PIM3 94 14
SRPK1 94 6
EF2K 100 10
EIF2AK3 97 2
HIPK1 75 9
HIPK2 103 21
HIPK3 79 3
CLK2 97 2
PAK2 65 12
PAK4 104 4
PAK5 89 5
PAK6 87 3
MST2 107 10
MST3 103 8
MST4 90 14
GCK 71 1
MINK1 94 13
MEKK1 90 17
MLK1 26 5
MLK3 62 10
TESK1 52 15
TAO1 92 7
ASK1 101 11
TAK1 104 4
IRAK1 83 4
IRAK4 88 10
RIPK2 22 7
OSR1 85 3
TTK 97 6
MPSK1 110 6
WNK1 100 1
Src 10 2
Lck 40 7
CSK 92 18
YES1 19 2
ABL 53 9
BTK 40 5
JAK2 91 6
SYK 114 17
ZAP70 95 4
TIE2 100 12
BRK 11 1
EPH-A2 16 2
EPH-A4 16 2
EPH-B1 14 11
EPH-B2 57 8
EPH-B3 70 2
EPH-B4 71 18
FGF-R1 84 21
HER4 57 10
IGF-1R 97 24
IR 100 1
IRR 93 0
TrkA 104 3
DDR2 9 1
VEGFR1 77 5
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 4
MKK2 85 0
MKK6 108 14
ERK1 98 8
ERK2 105 10
JNK1 90 2
JNK2 88 10
JNK3 93 2
p38 alpha MAPK 87 1
p38 beta MAPK 75 7
p38 gamma MAPK 89 8
p38 delta MAPK 97 5
ERK8 85 11
RSK1 64 4
RSK2 77 5
PDK1 100 7
PKB alpha 84 20
PKB beta 64 4
SGK1 95 1
S6K1 94 8
PKA 41 0
ROCK 2 85 11
PRK2 96 12
PKC alpha 109 3
PKC gamma 109 1
PKC zeta 101 3
PKD1 65 10
STK33 96 3
MSK1 83 9
MNK1 109 7
MNK2 96 12
MAPKAP-K2 98 20
MAPKAP-K3 74 2
PRAK 122 8
CAMKK beta 53 9
CAMK1 89 6
SmMLCK 90 11
PHK 54 6
DAPK1 87 5
CHK1 87 2
CHK2 33 3
GSK3 beta 96 2
CDK2-Cyclin A 108 6
CDK9-Cyclin T1 96 9
PLK1 95 4
Aurora A 58 7
Aurora B 79 5
TLK1 86 9
LKB1 100 2
AMPK 87 1
MARK1 70 5
MARK2 88 11
MARK3 72 1
MARK4 112 3
BRSK1 87 12
BRSK2 97 20
MELK 109 2
NUAK1 53 3
SIK2 7 4
SIK3 7 1
TSSK1 99 1
CK1 gamma 2 86 16
CK1 delta 82 9
CK2 100 9
TTBK1 107 7
DYRK1A 92 12
DYRK2 100 2
DYRK3 90 18
NEK2a 90 11
NEK6 94 5
IKK beta 88 25
IKK epsilon 110 15
TBK1 97 20
PIM1 109 4
PIM2 100 58
PIM3 98 1
SRPK1 90 0
EF2K 94 9
EIF2AK3 106 9
HIPK1 72 19
HIPK2 102 1
HIPK3 89 19
CLK2 100 6
PAK2 44 0
PAK4 96 11
PAK5 86 12
PAK6 97 11
MST2 79 4
MST3 85 11
MST4 79 4
GCK 22 2
MINK1 32 1
MEKK1 58 14
MLK1 6 2
MLK3 17 0
TESK1 20 10
TAO1 72 1
ASK1 108 19
TAK1 105 3
IRAK1 73 10
IRAK4 82 2
RIPK2 11 3
OSR1 75 6
TTK 96 3
MPSK1 103 6
WNK1 103 2
Src 3 0
Lck 48 7
CSK 36 6
YES1 8 1
ABL 35 6
BTK 16 0
JAK2 69 2
SYK 68 4
ZAP70 100 5
TIE2 50 10
BRK 4 1
EPH-A2 8 1
EPH-A4 9 1
EPH-B1 2 0
EPH-B2 2 0
EPH-B3 24 1
EPH-B4 5 0
FGF-R1 11 3
HER4 17 2
IGF-1R 112 38
IR 99 1
IRR 84 0
TrkA 63 15
DDR2 7 1
VEGFR1 30 8

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