Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PLX 4032 (Vemurafenib) C23H18ClF2N3O3S 489.92 B-RAF Bollag G. (2010) Nature 467 596-9 Axon Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 7
MKK2 56 4
MKK6 138 0
ERK1 94 8
ERK2 106 11
JNK1 71 5
JNK2 87 4
JNK3 94 15
p38 alpha MAPK 74 1
p38 beta MAPK 73 6
p38 gamma MAPK 107 12
p38 delta MAPK 86 7
ERK8 107 21
RSK1 103 8
RSK2 79 14
PDK1 106 13
PKB alpha 110 8
PKB beta 91 3
SGK1 101 4
S6K1 94 4
PKA 90 3
ROCK 2 86 7
PRK2 82 10
PKC alpha 107 9
PKC gamma 95 8
PKC zeta 96 14
PKD1 76 0
STK33 86 5
MSK1 106 5
MNK1 68 6
MNK2 85 6
MAPKAP-K2 115 1
MAPKAP-K3 93 7
PRAK 90 13
CAMKK beta 96 12
CAMK1 87 18
SmMLCK 89 9
PHK 90 4
DAPK1 91 3
CHK1 98 5
CHK2 93 4
GSK3 beta 85 23
CDK2-Cyclin A 81 14
PLK1 113 4
Aurora A 102 8
Aurora B 96 26
TLK1 102 6
LKB1 97 10
AMPK 79 1
MARK1 98 1
MARK2 102 8
MARK3 82 7
MARK4 79 1
BRSK1 101 2
BRSK2 90 5
MELK 99 32
NUAK1 80 3
TSSK1 100 16
CK1 delta 94 7
CK2 74 7
TTBK1 92 10
DYRK1A 85 2
DYRK2 100 4
DYRK3 92 1
NEK2a 91 1
NEK6 93 1
IKK beta 95 2
IKK epsilon 94 3
TBK1 97 5
PIM1 95 2
PIM2 96 1
PIM3 95 8
SRPK1 95 4
EF2K 90 6
EIF2AK3 78 0
HIPK1 97 17
HIPK2 92 3
HIPK3 89 1
CLK2 95 5
PAK2 92 5
PAK4 80 10
PAK5 90 3
PAK6 101 4
MST2 53 5
MST4 96 4
GCK 40 16
MINK1 27 3
MEKK1 98 10
MLK1 28 6
MLK3 75 3
TESK1 47 3
TAO1 117 0
ASK1 101 11
TAK1 67 14
IRAK1 105 4
IRAK4 93 5
RIPK2 28 15
OSR1 100 1
TTK 90 11
MPSK1 85 0
Src 32 16
Lck 32 1
CSK 23 2
YES1 37 3
ABL 96 0
BTK 82 7
JAK2 81 4
SYK 104 4
ZAP70 103 7
TIE2 80 1
BRK 27 8
EPH-A2 88 9
EPH-A4 92 10
EPH-B1 111 29
EPH-B2 92 6
EPH-B3 102 14
EPH-B4 101 11
FGF-R1 96 16
HER4 65 4
IGF-1R 82 14
IR 60 11
IRR 105 8
TrkA 90 1
VEGFR1 48 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 82 9
MKK2 75 5
MKK6 135 3
ERK1 100 2
ERK2 91 4
JNK1 89 9
JNK2 98 5
JNK3 90 10
p38 alpha MAPK 30 0
p38 beta MAPK 90 8
p38 gamma MAPK 102 17
p38 delta MAPK 81 8
ERK8 97 4
RSK1 60 0
RSK2 57 10
PDK1 99 5
PKB alpha 98 0
PKB beta 71 28
SGK1 98 4
S6K1 102 3
PKA 99 13
ROCK 2 87 1
PRK2 83 6
PKC alpha 100 9
PKC gamma 95 4
PKC zeta 98 7
PKD1 72 9
STK33 83 3
MSK1 100 5
MNK1 107 7
MNK2 94 6
MAPKAP-K2 115 15
MAPKAP-K3 94 4
PRAK 110 11
CAMKK beta 99 9
CAMK1 14 4
SmMLCK 54 5
PHK 67 2
DAPK1 90 8
CHK1 92 2
CHK2 84 7
GSK3 beta 83 13
CDK2-Cyclin A 90 5
PLK1 102 1
Aurora A 98 6
Aurora B 97 23
TLK1 103 2
LKB1 89 1
AMPK 79 12
MARK1 99 9
MARK2 101 0
MARK3 88 5
MARK4 69 11
BRSK1 107 9
BRSK2 99 2
MELK 91 3
NUAK1 87 6
TSSK1 95 5
CK1 delta 92 5
CK2 83 3
TTBK1 98 15
DYRK1A 43 2
DYRK2 96 5
DYRK3 97 5
NEK2a 77 5
NEK6 81 7
IKK beta 98 11
IKK epsilon 81 10
TBK1 97 1
PIM1 94 7
PIM2 81 8
PIM3 96 1
SRPK1 97 5
EF2K 79 12
EIF2AK3 76 11
HIPK1 102 4
HIPK2 92 7
HIPK3 82 7
CLK2 103 11
PAK2 92 2
PAK4 86 14
PAK5 95 4
PAK6 98 2
MST2 89 6
MST4 93 4
GCK 79 3
MINK1 10 11
MEKK1 87 8
MLK1 89 1
MLK3 92 11
TESK1 51 17
TAO1 99 7
ASK1 105 10
TAK1 73 5
IRAK1 98 0
IRAK4 92 6
RIPK2 52 12
OSR1 105 6
TTK 94 4
MPSK1 86 7
Src 3 3
Lck 17 2
CSK 50 4
YES1 87 7
ABL 93 1
BTK 86 1
JAK2 83 3
SYK 82 1
ZAP70 114 4
TIE2 82 4
BRK 42 16
EPH-A2 75 14
EPH-A4 91 5
EPH-B1 104 7
EPH-B2 94 1
EPH-B3 98 2
EPH-B4 86 15
FGF-R1 110 10
HER4 85 2
IGF-1R 69 11
IR 82 10
IRR 95 12
TrkA 97 21
VEGFR1 96 3

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