Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CZC-25146 C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
JNK1 2 0
CHK2 4 0
VEGFR1 6 4
JNK2 7 4
MLK1 8 0
IGF-1R 8 5
Aurora B 8 1
CAMKK beta 8 1
PHK 8 0
TSSK1 9 2
Aurora A 9 1
PAK4 9 6
MLK3 11 0
DAPK1 11 2
RSK1 12 0
JNK3 13 1
HER4 14 1
MARK3 14 4
DYRK2 16 2
IRAK4 16 0
SIK2 17 1
ERK8 17 0
SmMLCK 18 3
BRSK2 18 5
NUAK1 20 11
STK33 20 3
PLK1 20 12
YES1 22 9
JAK2 22 0
MARK1 23 17
IR 27 4
BRSK1 27 0
FGF-R1 30 2
DDR2 31 7
CHK1 32 6
PRK2 33 8
GCK 34 2
HIPK2 34 4
IRAK1 34 7
S6K1 35 2
AMPK 36 4
TIE2 36 11
TTK 36 3
SYK 38 3
PAK5 38 6
RSK2 39 4
DYRK3 39 5
MARK2 40 3
PKD1 41 3
BTK 41 6
IRR 41 7
EIF2AK3 42 11
ZAP70 44 0
MARK4 44 2
MELK 44 4
MNK1 45 3
MKK6 45 3
MNK2 46 27
MST2 46 25
TAO1 48 3
RIPK2 48 14
CK2 51 8
Src 52 3
TBK1 54 1
TrkA 57 19
IKK epsilon 57 1
SIK3 58 14
MAPKAP-K3 58 6
NEK2a 58 4
PDK1 60 1
BRK 60 72
HIPK3 61 7
SRPK1 67 4
CSK 67 5
CLK2 67 65
TESK1 68 19
TAK1 69 11
DYRK1A 73 2
OSR1 73 0
ABL 74 12
MSK1 75 7
CDK9-Cyclin T1 76 5
PIM3 76 4
PKC gamma 76 8
MKK2 78 1
EPH-B1 79 3
PKB beta 80 12
ERK1 80 2
CAMK1 80 15
PAK6 80 16
MKK1 81 3
Lck 82 24
LKB1 82 3
PKA 82 1
MINK1 83 5
p38 alpha MAPK 85 13
MEKK1 87 6
CK1 delta 87 3
p38 delta MAPK 88 15
MAPKAP-K2 89 1
NEK6 89 18
GSK3 beta 90 23
PRAK 90 24
IKK beta 90 20
WNK1 92 4
EPH-B3 93 5
p38 gamma MAPK 93 9
TLK1 93 4
TTBK1 93 4
ROCK 2 93 10
PIM2 94 12
CK1 gamma 2 94 10
EF2K 94 8
EPH-A4 94 17
EPH-B4 95 7
EPH-B2 95 4
PIM1 96 3
PKC alpha 97 4
PKB alpha 98 9
SGK1 98 5
MST3 98 3
PKC zeta 99 1
MPSK1 100 8
CDK2-Cyclin A 101 1
PAK2 101 12
EPH-A2 102 6
p38 beta MAPK 104 7
ASK1 105 5
ERK2 106 2
MST4 109 20
HIPK1 123 2
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
CHK2 7 1
CAMKK beta 10 1
VEGFR1 11 2
MLK1 16 5
JNK1 21 5
MLK3 22 4
JNK3 23 5
JNK2 25 7
PHK 26 0
STK33 31 6
TSSK1 35 1
PAK4 42 3
IGF-1R 47 2
MARK3 49 11
DAPK1 50 10
IR 52 11
NUAK1 53 1
RSK1 54 0
DYRK2 56 1
Aurora B 58 2
HER4 59 6
ERK8 61 2
BRK 62 20
SmMLCK 64 2
SIK2 68 11
MAPKAP-K3 68 7
BRSK2 69 10
Aurora A 70 4
CLK2 71 8
GCK 72 2
IRAK4 73 3
PRK2 74 4
JAK2 75 12
DDR2 76 4
MARK2 76 1
MNK1 79 0
RSK2 79 2
AMPK 80 18
TTK 81 1
IRR 82 1
RIPK2 82 3
PLK1 83 46
YES1 83 6
MKK6 84 1
TIE2 84 8
EIF2AK3 85 7
DYRK3 86 0
Src 87 4
FGF-R1 87 0
HIPK2 87 6
TAO1 87 8
IRAK1 87 3
BRSK1 88 1
BTK 89 1
PAK5 89 19
LKB1 90 5
CAMK1 90 0
MELK 91 6
GSK3 beta 91 8
MNK2 92 27
PDK1 92 0
MARK4 92 13
DYRK1A 93 13
OSR1 94 10
PKD1 94 1
HIPK1 94 14
PKB beta 94 0
CDK9-Cyclin T1 95 2
CHK1 96 8
MAPKAP-K2 96 6
p38 delta MAPK 97 11
SIK3 97 7
MSK1 97 4
ERK1 97 20
PKA 97 4
NEK2a 97 2
TESK1 98 1
S6K1 98 5
p38 gamma MAPK 99 3
CK2 99 3
EPH-B1 100 7
PRAK 100 0
HIPK3 100 9
MARK1 100 11
ZAP70 100 7
PAK6 101 10
Lck 101 9
SRPK1 101 10
SYK 101 1
TBK1 102 4
CSK 102 4
TLK1 103 14
CK1 gamma 2 104 1
CK1 delta 104 1
ABL 104 3
MST2 105 30
TTBK1 106 6
TrkA 106 14
PAK2 106 8
PIM2 107 12
PIM3 107 3
MINK1 107 1
PKB alpha 107 14
IKK beta 108 1
p38 alpha MAPK 108 6
EPH-B3 108 9
MST3 109 12
p38 beta MAPK 109 4
MKK1 109 6
EPH-A4 110 6
PKC alpha 110 6
PKC zeta 110 6
MEKK1 110 11
EPH-B2 111 25
TAK1 111 18
MPSK1 112 10
EF2K 112 2
MKK2 112 10
PIM1 113 1
WNK1 113 10
SGK1 114 1
ROCK 2 117 16
NEK6 117 8
IKK epsilon 118 19
PKC gamma 118 0
EPH-A2 119 11
ASK1 121 1
MST4 122 36
CDK2-Cyclin A 123 39
ERK2 127 17
EPH-B4 128 1

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