Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CZC-25146 C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 81 3
MKK2 78 1
MKK6 45 3
ERK1 80 2
ERK2 106 2
JNK1 2 0
JNK2 7 4
JNK3 13 1
p38 alpha MAPK 85 13
p38 beta MAPK 104 7
p38 gamma MAPK 93 9
p38 delta MAPK 88 15
ERK8 17 0
RSK1 12 0
RSK2 39 4
PDK1 60 1
PKB alpha 98 9
PKB beta 80 12
SGK1 98 5
S6K1 35 2
PKA 82 1
ROCK 2 93 10
PRK2 33 8
PKC alpha 97 4
PKC gamma 76 8
PKC zeta 99 1
PKD1 41 3
STK33 20 3
MSK1 75 7
MNK1 45 3
MNK2 46 27
MAPKAP-K2 89 1
MAPKAP-K3 58 6
PRAK 90 24
CAMKK beta 8 1
CAMK1 80 15
SmMLCK 18 3
PHK 8 0
DAPK1 11 2
CHK1 32 6
CHK2 4 0
GSK3 beta 90 23
CDK2-Cyclin A 101 1
CDK9-Cyclin T1 76 5
PLK1 20 12
Aurora A 9 1
Aurora B 8 1
TLK1 93 4
LKB1 82 3
AMPK 36 4
MARK1 23 17
MARK2 40 3
MARK3 14 4
MARK4 44 2
BRSK1 27 0
BRSK2 18 5
MELK 44 4
NUAK1 20 11
SIK2 17 1
SIK3 58 14
TSSK1 9 2
CK1 gamma 2 94 10
CK1 delta 87 3
CK2 51 8
TTBK1 93 4
DYRK1A 73 2
DYRK2 16 2
DYRK3 39 5
NEK2a 58 4
NEK6 89 18
IKK beta 90 20
IKK epsilon 57 1
TBK1 54 1
PIM1 96 3
PIM2 94 12
PIM3 76 4
SRPK1 67 4
EF2K 94 8
EIF2AK3 42 11
HIPK1 123 2
HIPK2 34 4
HIPK3 61 7
CLK2 67 65
PAK2 101 12
PAK4 9 6
PAK5 38 6
PAK6 80 16
MST2 46 25
MST3 98 3
MST4 109 20
GCK 34 2
MINK1 83 5
MEKK1 87 6
MLK1 8 0
MLK3 11 0
TESK1 68 19
TAO1 48 3
ASK1 105 5
TAK1 69 11
IRAK1 34 7
IRAK4 16 0
RIPK2 48 14
OSR1 73 0
TTK 36 3
MPSK1 100 8
WNK1 92 4
Src 52 3
Lck 82 24
CSK 67 5
YES1 22 9
ABL 74 12
BTK 41 6
JAK2 22 0
SYK 38 3
ZAP70 44 0
TIE2 36 11
BRK 60 72
EPH-A2 102 6
EPH-A4 94 17
EPH-B1 79 3
EPH-B2 95 4
EPH-B3 93 5
EPH-B4 95 7
FGF-R1 30 2
HER4 14 1
IGF-1R 8 5
IR 27 4
IRR 41 7
TrkA 57 19
DDR2 31 7
VEGFR1 6 4
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 109 6
MKK2 112 10
MKK6 84 1
ERK1 97 20
ERK2 127 17
JNK1 21 5
JNK2 25 7
JNK3 23 5
p38 alpha MAPK 108 6
p38 beta MAPK 109 4
p38 gamma MAPK 99 3
p38 delta MAPK 97 11
ERK8 61 2
RSK1 54 0
RSK2 79 2
PDK1 92 0
PKB alpha 107 14
PKB beta 94 0
SGK1 114 1
S6K1 98 5
PKA 97 4
ROCK 2 117 16
PRK2 74 4
PKC alpha 110 6
PKC gamma 118 0
PKC zeta 110 6
PKD1 94 1
STK33 31 6
MSK1 97 4
MNK1 79 0
MNK2 92 27
MAPKAP-K2 96 6
MAPKAP-K3 68 7
PRAK 100 0
CAMKK beta 10 1
CAMK1 90 0
SmMLCK 64 2
PHK 26 0
DAPK1 50 10
CHK1 96 8
CHK2 7 1
GSK3 beta 91 8
CDK2-Cyclin A 123 39
CDK9-Cyclin T1 95 2
PLK1 83 46
Aurora A 70 4
Aurora B 58 2
TLK1 103 14
LKB1 90 5
AMPK 80 18
MARK1 100 11
MARK2 76 1
MARK3 49 11
MARK4 92 13
BRSK1 88 1
BRSK2 69 10
MELK 91 6
NUAK1 53 1
SIK2 68 11
SIK3 97 7
TSSK1 35 1
CK1 gamma 2 104 1
CK1 delta 104 1
CK2 99 3
TTBK1 106 6
DYRK1A 93 13
DYRK2 56 1
DYRK3 86 0
NEK2a 97 2
NEK6 117 8
IKK beta 108 1
IKK epsilon 118 19
TBK1 102 4
PIM1 113 1
PIM2 107 12
PIM3 107 3
SRPK1 101 10
EF2K 112 2
EIF2AK3 85 7
HIPK1 94 14
HIPK2 87 6
HIPK3 100 9
CLK2 71 8
PAK2 106 8
PAK4 42 3
PAK5 89 19
PAK6 101 10
MST2 105 30
MST3 109 12
MST4 122 36
GCK 72 2
MINK1 107 1
MEKK1 110 11
MLK1 16 5
MLK3 22 4
TESK1 98 1
TAO1 87 8
ASK1 121 1
TAK1 111 18
IRAK1 87 3
IRAK4 73 3
RIPK2 82 3
OSR1 94 10
TTK 81 1
MPSK1 112 10
WNK1 113 10
Src 87 4
Lck 101 9
CSK 102 4
YES1 83 6
ABL 104 3
BTK 89 1
JAK2 75 12
SYK 101 1
ZAP70 100 7
TIE2 84 8
BRK 62 20
EPH-A2 119 11
EPH-A4 110 6
EPH-B1 100 7
EPH-B2 111 25
EPH-B3 108 9
EPH-B4 128 1
FGF-R1 87 0
HER4 59 6
IGF-1R 47 2
IR 52 11
IRR 82 1
TrkA 106 14
DDR2 76 4
VEGFR1 11 2

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