Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Ischemin C15H17N3O4S 335.38 p53 CBP Jagat C. Borah (2011) Chemistry & Biology, 18 4 531-541 Download

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100µM

Results as Table

Screening Concentration: 100µM
Kinase % Activity Remainingsort descending Standard Deviation
GSK3 beta 31 3
TAK1 31 5
Aurora A 32 5
PKB beta 37 7
Src 40 2
HIPK2 42 14
NUAK1 44 7
CAMK1 45 1
PIM3 45 7
BRSK2 46 5
RIPK2 46 4
EPH-B3 48 3
CK2 51 0
YES1 52 8
SGK1 52 5
PKC gamma 55 9
PKD1 55 11
PIM2 58 0
p38 alpha MAPK 58 2
MLK1 58 12
p38 beta MAPK 58 5
FGF-R1 59 6
SRPK1 59 4
PIM1 62 2
MINK1 62 7
VEGFR1 62 0
MAPKAP-K3 62 7
TrkA 65 4
ERK8 65 8
DYRK3 65 4
MST4 67 0
PAK4 70 6
PRAK 70 8
JAK2 71 4
AMPK 71 2
TESK1 73 2
HIPK3 74 8
BRSK1 76 1
DYRK2 78 1
PLK1 79 8
GCK 80 0
RSK2 80 1
MST2 81 6
MARK4 81 7
PKC alpha 81 4
DAPK1 82 3
MLK3 83 7
MSK1 84 8
PHK 86 4
MELK 87 9
PAK5 87 9
MEKK1 88 16
EPH-A2 89 6
PKA 90 2
PDK1 90 1
TTK 90 4
ABL 92 1
EF2K 92 7
EPH-A4 92 5
Aurora B 93 3
IKK epsilon 94 1
TBK1 94 1
CDK2-Cyclin A 94 8
EIF2AK3 94 1
HIPK1 94 6
TTBK1 94 13
MARK3 96 9
PAK6 96 12
EPH-B2 96 9
SmMLCK 97 7
PKC zeta 97 6
OSR1 97 4
EPH-B1 97 7
IKK beta 97 12
ERK1 98 8
MARK2 98 2
HER4 99 7
RSK1 99 2
MNK1 99 5
MARK1 99 1
CAMKK beta 99 2
JNK3 100 9
CHK2 100 1
MNK2 100 3
BRK 100 4
PAK2 100 4
CLK2 101 28
S6K1 102 1
BTK 102 8
IRR 103 13
SYK 103 8
ZAP70 103 3
TIE2 103 1
MKK1 103 8
IRAK1 104 3
ROCK 2 105 0
TSSK1 107 2
STK33 107 14
MAPKAP-K2 107 8
p38 gamma MAPK 108 3
CK1 delta 108 24
TLK1 108 0
IRAK4 108 20
PKB alpha 108 10
IGF-1R 109 2
p38 delta MAPK 109 8
TAO1 109 3
MKK2 109 3
MPSK1 111 5
Lck 112 1
JNK2 112 2
JNK1 113 0
DYRK1A 113 7
MKK6 113 8
NEK2a 118 6
EPH-B4 123 8
PRK2 126 6
LKB1 126 1
CSK 132 11
ERK2 134 0
IR 141 8
NEK6 146 63
ASK1 151 9
CHK1 196 6

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