Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
ETP 46464 C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
GCK 11 3
NUAK1 16 0
JAK2 31 5
RIPK2 38 5
NEK6 40 4
MST2 49 0
MELK 49 9
TrkA 53 30
MSK1 53 5
MINK1 55 5
PIM3 55 15
IRAK1 56 10
CAMKK beta 59 3
DYRK3 64 7
ERK8 67 2
IGF-1R 67 3
RSK1 73 0
PIM1 73 3
MKK2 75 13
SYK 76 2
IRR 77 3
ZAP70 77 3
JNK3 77 8
TAK1 78 12
PAK5 80 9
PKD1 81 10
EPH-A2 81 3
Aurora B 82 6
MAPKAP-K3 82 31
SGK1 82 4
MLK3 83 6
DYRK1A 83 1
ERK1 83 4
MST4 83 5
PDK1 84 10
PRK2 84 8
BTK 85 3
CDK2-Cyclin A 85 5
DYRK2 85 3
LKB1 85 3
MEKK1 85 3
TTK 86 5
MARK4 86 8
BRSK1 86 5
PLK1 87 7
IKK beta 87 7
DAPK1 88 15
GSK3 beta 89 0
IRAK4 89 4
AMPK 89 4
EPH-A4 89 0
PRAK 89 5
CSK 89 9
SRPK1 89 1
MLK1 89 4
MNK1 90 0
CLK2 91 7
MKK6 92 14
PKA 92 1
PHK 92 6
FGF-R1 93 1
YES1 93 8
TAO1 94 4
HIPK3 94 1
PKC alpha 94 1
CHK2 94 3
CK1 delta 95 19
p38 delta MAPK 95 3
TIE2 95 2
MARK2 95 7
EPH-B2 95 10
ERK2 95 9
PKC zeta 96 22
MKK1 96 2
S6K1 96 2
TBK1 96 8
EPH-B4 96 1
PIM2 96 1
IR 96 3
EIF2AK3 97 3
CK2 97 7
HIPK1 97 6
BRK 97 11
IKK epsilon 97 1
JNK2 97 2
HER4 97 6
STK33 98 4
Lck 98 9
MNK2 99 5
PKC gamma 99 10
p38 gamma MAPK 100 12
TTBK1 100 11
RSK2 100 11
PKB beta 100 7
MPSK1 100 17
SmMLCK 100 1
BRSK2 100 11
CHK1 100 4
TLK1 101 3
MARK3 102 3
p38 beta MAPK 103 0
TSSK1 103 1
NEK2a 103 11
OSR1 103 15
CAMK1 103 25
EPH-B3 103 11
ABL 103 1
ROCK 2 104 8
VEGFR1 107 11
PAK2 107 8
TESK1 108 3
Aurora A 108 10
MAPKAP-K2 108 21
PAK4 108 38
EF2K 109 3
JNK1 109 10
PAK6 110 4
ASK1 111 1
HIPK2 114 3
MARK1 114 4
PKB alpha 117 12
EPH-B1 119 8
Src 130 13
p38 alpha MAPK 134 15
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
GCK 22 3
JAK2 26 4
NUAK1 32 1
MELK 49 12
TrkA 50 5
DYRK3 57 1
RIPK2 57 2
PKC zeta 58 56
TAK1 64 5
MST2 64 9
PIM3 67 19
EPH-A2 69 14
CAMKK beta 69 4
MEKK1 69 12
MINK1 72 6
DYRK2 73 14
CAMK1 73 1
ERK8 73 1
GSK3 beta 74 9
IRR 74 3
MSK1 74 5
CLK2 75 1
CSK 75 0
ZAP70 75 4
MKK1 78 6
Lck 78 7
IRAK1 79 1
PKD1 79 5
PKA 81 22
PIM1 81 11
CHK1 81 5
MLK3 81 3
PRAK 82 9
NEK6 83 2
ERK2 83 7
TBK1 83 8
Src 83 8
TLK1 84 15
DAPK1 84 2
ERK1 85 1
IKK beta 86 6
LKB1 87 5
MKK2 87 3
MPSK1 87 3
SmMLCK 87 6
JNK3 87 1
VEGFR1 87 13
MAPKAP-K3 88 19
p38 gamma MAPK 88 5
MNK1 89 1
DYRK1A 89 4
RSK2 89 14
EPH-A4 89 1
BRSK2 89 8
IGF-1R 89 12
p38 beta MAPK 89 6
IRAK4 90 3
PRK2 90 10
SRPK1 90 7
BTK 90 12
CDK2-Cyclin A 90 4
AMPK 91 4
TTK 91 2
S6K1 91 3
PIM2 91 3
MLK1 91 7
TAO1 91 0
YES1 92 15
CK1 delta 92 7
Aurora B 93 5
TIE2 93 8
PDK1 93 7
EPH-B1 93 2
EPH-B2 93 18
MARK3 93 4
MST4 93 6
p38 alpha MAPK 93 7
ABL 93 8
PLK1 93 3
MNK2 94 2
PAK4 94 3
HIPK1 94 12
PAK2 95 7
CHK2 95 14
RSK1 96 10
HIPK3 96 6
BRK 96 10
MARK1 96 9
SGK1 96 4
IR 96 7
p38 delta MAPK 96 9
PHK 97 2
BRSK1 97 2
JNK2 97 21
CK2 97 1
PAK6 98 5
FGF-R1 98 18
PAK5 99 9
EF2K 99 1
HIPK2 99 2
MARK4 100 16
MKK6 101 3
MARK2 101 5
PKC alpha 101 4
EIF2AK3 101 1
Aurora A 101 4
PKB alpha 102 2
OSR1 102 10
EPH-B4 102 9
PKB beta 105 23
SYK 105 7
JNK1 106 9
NEK2a 108 3
HER4 110 18
TSSK1 110 24
TTBK1 110 4
IKK epsilon 111 4
PKC gamma 111 0
MAPKAP-K2 115 18
STK33 115 25
EPH-B3 116 2
TESK1 116 8
ASK1 117 3
ROCK 2 120 19

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