Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
ETP 46464 C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 78 6
MKK2 87 3
MKK6 101 3
ERK1 85 1
ERK2 83 7
JNK1 106 9
JNK2 97 21
JNK3 87 1
p38 alpha MAPK 93 7
p38 beta MAPK 89 6
p38 gamma MAPK 88 5
p38 delta MAPK 96 9
ERK8 73 1
RSK1 96 10
RSK2 89 14
PDK1 93 7
PKB alpha 102 2
PKB beta 105 23
SGK1 96 4
S6K1 91 3
PKA 81 22
ROCK 2 120 19
PRK2 90 10
PKC alpha 101 4
PKC gamma 111 0
PKC zeta 58 56
PKD1 79 5
STK33 115 25
MSK1 74 5
MNK1 89 1
MNK2 94 2
MAPKAP-K2 115 18
MAPKAP-K3 88 19
PRAK 82 9
CAMKK beta 69 4
CAMK1 73 1
SmMLCK 87 6
PHK 97 2
DAPK1 84 2
CHK1 81 5
CHK2 95 14
GSK3 beta 74 9
CDK2-Cyclin A 90 4
PLK1 93 3
Aurora A 101 4
Aurora B 93 5
TLK1 84 15
LKB1 87 5
AMPK 91 4
MARK1 96 9
MARK2 101 5
MARK3 93 4
MARK4 100 16
BRSK1 97 2
BRSK2 89 8
MELK 49 12
NUAK1 32 1
TSSK1 110 24
CK1 delta 92 7
CK2 97 1
TTBK1 110 4
DYRK1A 89 4
DYRK2 73 14
DYRK3 57 1
NEK2a 108 3
NEK6 83 2
IKK beta 86 6
IKK epsilon 111 4
TBK1 83 8
PIM1 81 11
PIM2 91 3
PIM3 67 19
SRPK1 90 7
EF2K 99 1
EIF2AK3 101 1
HIPK1 94 12
HIPK2 99 2
HIPK3 96 6
CLK2 75 1
PAK2 95 7
PAK4 94 3
PAK5 99 9
PAK6 98 5
MST2 64 9
MST4 93 6
GCK 22 3
MINK1 72 6
MEKK1 69 12
MLK1 91 7
MLK3 81 3
TESK1 116 8
TAO1 91 0
ASK1 117 3
TAK1 64 5
IRAK1 79 1
IRAK4 90 3
RIPK2 57 2
OSR1 102 10
TTK 91 2
MPSK1 87 3
Src 83 8
Lck 78 7
CSK 75 0
YES1 92 15
ABL 93 8
BTK 90 12
JAK2 26 4
SYK 105 7
ZAP70 75 4
TIE2 93 8
BRK 96 10
EPH-A2 69 14
EPH-A4 89 1
EPH-B1 93 2
EPH-B2 93 18
EPH-B3 116 2
EPH-B4 102 9
FGF-R1 98 18
HER4 110 18
IGF-1R 89 12
IR 96 7
IRR 74 3
TrkA 50 5
VEGFR1 87 13
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 96 2
MKK2 75 13
MKK6 92 14
ERK1 83 4
ERK2 95 9
JNK1 109 10
JNK2 97 2
JNK3 77 8
p38 alpha MAPK 134 15
p38 beta MAPK 103 0
p38 gamma MAPK 100 12
p38 delta MAPK 95 3
ERK8 67 2
RSK1 73 0
RSK2 100 11
PDK1 84 10
PKB alpha 117 12
PKB beta 100 7
SGK1 82 4
S6K1 96 2
PKA 92 1
ROCK 2 104 8
PRK2 84 8
PKC alpha 94 1
PKC gamma 99 10
PKC zeta 96 22
PKD1 81 10
STK33 98 4
MSK1 53 5
MNK1 90 0
MNK2 99 5
MAPKAP-K2 108 21
MAPKAP-K3 82 31
PRAK 89 5
CAMKK beta 59 3
CAMK1 103 25
SmMLCK 100 1
PHK 92 6
DAPK1 88 15
CHK1 100 4
CHK2 94 3
GSK3 beta 89 0
CDK2-Cyclin A 85 5
PLK1 87 7
Aurora A 108 10
Aurora B 82 6
TLK1 101 3
LKB1 85 3
AMPK 89 4
MARK1 114 4
MARK2 95 7
MARK3 102 3
MARK4 86 8
BRSK1 86 5
BRSK2 100 11
MELK 49 9
NUAK1 16 0
TSSK1 103 1
CK1 delta 95 19
CK2 97 7
TTBK1 100 11
DYRK1A 83 1
DYRK2 85 3
DYRK3 64 7
NEK2a 103 11
NEK6 40 4
IKK beta 87 7
IKK epsilon 97 1
TBK1 96 8
PIM1 73 3
PIM2 96 1
PIM3 55 15
SRPK1 89 1
EF2K 109 3
EIF2AK3 97 3
HIPK1 97 6
HIPK2 114 3
HIPK3 94 1
CLK2 91 7
PAK2 107 8
PAK4 108 38
PAK5 80 9
PAK6 110 4
MST2 49 0
MST4 83 5
GCK 11 3
MINK1 55 5
MEKK1 85 3
MLK1 89 4
MLK3 83 6
TESK1 108 3
TAO1 94 4
ASK1 111 1
TAK1 78 12
IRAK1 56 10
IRAK4 89 4
RIPK2 38 5
OSR1 103 15
TTK 86 5
MPSK1 100 17
Src 130 13
Lck 98 9
CSK 89 9
YES1 93 8
ABL 103 1
BTK 85 3
JAK2 31 5
SYK 76 2
ZAP70 77 3
TIE2 95 2
BRK 97 11
EPH-A2 81 3
EPH-A4 89 0
EPH-B1 119 8
EPH-B2 95 10
EPH-B3 103 11
EPH-B4 96 1
FGF-R1 93 1
HER4 97 6
IGF-1R 67 3
IR 96 3
IRR 77 3
TrkA 53 30
VEGFR1 107 11

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