Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Amgen TBK 1 inhibitor (Compound II) C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
LKB1 119 14
PKC gamma 117 7
p38 gamma MAPK 113 16
ERK1 111 12
PIM2 108 16
SGK1 107 10
MAPKAP-K2 105 25
MINK1 104 14
IGF-1R 104 19
SRPK1 104 4
TTBK1 104 11
MEKK1 103 7
p38 beta MAPK 103 2
OSR1 101 14
MPSK1 101 1
SmMLCK 100 6
EF2K 100 13
PKD1 100 0
PKB alpha 99 12
MKK6 99 5
ASK1 99 3
PRAK 98 12
p38 alpha MAPK 98 4
MAPKAP-K3 97 3
PDK1 96 4
PIM1 96 17
PKC alpha 95 15
CK1 delta 95 1
TAO1 95 7
PKC zeta 94 21
p38 delta MAPK 93 21
MARK4 92 24
PIM3 91 6
MST4 90 18
EIF2AK3 90 20
PLK1 90 11
NEK6 89 2
JNK1 89 13
PKB beta 88 17
IKK beta 86 8
EPH-B3 86 16
JNK2 85 21
ERK2 84 13
BRSK2 84 5
TTK 81 1
TLK1 79 1
IR 79 4
MST2 78 5
PKA 78 11
IRR 78 9
MSK1 76 8
DYRK3 75 30
BRSK1 74 2
CHK1 72 0
S6K1 70 15
EPH-B4 69 13
HIPK3 69 12
MNK2 67 9
MARK2 67 4
CAMK1 67 2
CSK 65 5
JNK3 65 13
IRAK4 64 11
MARK1 63 6
PAK6 62 8
RSK1 62 44
HER4 60 4
TIE2 60 4
TESK1 59 10
MNK1 59 5
CAMKK beta 58 4
SYK 58 7
PRK2 57 3
DYRK1A 57 3
PHK 56 1
MKK2 55 7
ZAP70 54 1
PAK5 53 0
DAPK1 51 5
DYRK2 50 5
PAK2 50 14
ROCK 2 49 5
CHK2 48 0
BRK 46 4
HIPK1 44 13
MARK3 41 9
MKK1 40 8
RSK2 38 1
MELK 37 0
GSK3 beta 37 6
Aurora B 36 1
CDK2-Cyclin A 34 2
CK2 33 2
TrkA 32 4
ABL 31 2
TSSK1 31 7
HIPK2 31 11
CLK2 30 10
STK33 30 2
PAK4 29 1
GCK 29 9
EPH-A2 28 12
RIPK2 28 5
IKK epsilon 28 6
AMPK 25 4
EPH-B2 23 11
NEK2a 22 2
BTK 22 2
ERK8 22 6
FGF-R1 20 1
IRAK1 19 3
Aurora A 18 3
YES1 16 9
NUAK1 16 2
MLK3 15 5
EPH-A4 14 0
TBK1 14 0
TAK1 14 3
Lck 10 2
EPH-B1 8 0
Src 7 1
MLK1 7 1
VEGFR1 5 1
JAK2 4 0
Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
MAPKAP-K2 108 5
PIM2 106 6
TTBK1 102 8
p38 beta MAPK 95 14
p38 gamma MAPK 95 1
MEKK1 92 9
EF2K 91 5
PLK1 91 7
PKB alpha 89 7
SRPK1 87 1
p38 alpha MAPK 85 12
PRAK 85 1
ERK1 82 0
MAPKAP-K3 81 12
PKC zeta 78 5
ASK1 77 5
PKB beta 77 0
MKK6 75 4
TAO1 74 8
LKB1 73 2
SmMLCK 72 11
PKC gamma 71 19
OSR1 71 4
CK1 delta 69 8
p38 delta MAPK 68 2
MST4 67 2
TTK 64 4
PIM3 63 4
PIM1 62 0
SGK1 61 1
MST2 61 39
NEK6 59 5
ERK2 57 5
MINK1 57 5
GCK 56 22
PKC alpha 56 9
IKK beta 55 6
PKD1 48 6
MPSK1 42 5
JNK3 39 0
TLK1 39 0
JNK1 38 0
CSK 38 15
PDK1 36 3
BRSK2 35 7
IRR 35 3
MSK1 34 4
JNK2 33 1
EPH-A2 32 26
EIF2AK3 31 0
MARK1 31 14
CAMKK beta 28 1
MARK2 28 9
S6K1 28 3
MKK2 28 4
PRK2 27 4
MELK 27 4
CAMK1 26 2
PKA 26 5
ROCK 2 25 5
PAK6 24 2
MARK4 24 5
TESK1 24 5
STK33 23 3
ZAP70 22 4
AMPK 22 0
IR 21 7
CHK1 20 1
IRAK4 20 1
HIPK3 19 0
TAK1 19 12
IKK epsilon 18 4
PAK5 18 0
BRSK1 17 1
HER4 17 1
HIPK1 17 4
MNK1 17 0
MNK2 17 5
MARK3 16 1
EPH-B3 16 4
DYRK2 16 2
DAPK1 15 1
BTK 14 1
PAK2 14 1
RIPK2 14 1
NUAK1 13 1
SYK 13 0
MKK1 13 2
PHK 12 1
CHK2 12 2
DYRK1A 12 1
TrkA 11 1
Aurora B 11 3
TIE2 11 4
CLK2 11 4
HIPK2 10 1
DYRK3 10 2
RSK2 9 1
PAK4 9 0
TBK1 8 1
FGF-R1 8 4
MLK3 8 0
YES1 7 2
ABL 7 3
CDK2-Cyclin A 7 1
RSK1 7 0
EPH-B2 6 2
IGF-1R 6 1
MLK1 6 0
GSK3 beta 6 1
CK2 6 5
BRK 6 1
TSSK1 5 0
IRAK1 5 2
EPH-A4 5 1
Lck 4 0
ERK8 4 1
Src 3 0
EPH-B4 3 0
JAK2 3 1
Aurora A 3 1
NEK2a 3 1
EPH-B1 3 1
VEGFR1 2 0

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