Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Amgen TBK 1 inhibitor (Compound II) C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470 Download

Results as Barchart

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0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
VEGFR1 2 0
NEK2a 3 1
EPH-B1 3 1
Src 3 0
EPH-B4 3 0
JAK2 3 1
Aurora A 3 1
Lck 4 0
ERK8 4 1
IRAK1 5 2
EPH-A4 5 1
TSSK1 5 0
BRK 6 1
EPH-B2 6 2
IGF-1R 6 1
MLK1 6 0
GSK3 beta 6 1
CK2 6 5
RSK1 7 0
YES1 7 2
ABL 7 3
CDK2-Cyclin A 7 1
TBK1 8 1
FGF-R1 8 4
MLK3 8 0
RSK2 9 1
PAK4 9 0
DYRK3 10 2
HIPK2 10 1
Aurora B 11 3
TIE2 11 4
CLK2 11 4
TrkA 11 1
DYRK1A 12 1
PHK 12 1
CHK2 12 2
MKK1 13 2
NUAK1 13 1
SYK 13 0
PAK2 14 1
RIPK2 14 1
BTK 14 1
DAPK1 15 1
DYRK2 16 2
MARK3 16 1
EPH-B3 16 4
MNK1 17 0
MNK2 17 5
BRSK1 17 1
HER4 17 1
HIPK1 17 4
PAK5 18 0
IKK epsilon 18 4
HIPK3 19 0
TAK1 19 12
IRAK4 20 1
CHK1 20 1
IR 21 7
AMPK 22 0
ZAP70 22 4
STK33 23 3
PAK6 24 2
MARK4 24 5
TESK1 24 5
ROCK 2 25 5
CAMK1 26 2
PKA 26 5
PRK2 27 4
MELK 27 4
MKK2 28 4
CAMKK beta 28 1
MARK2 28 9
S6K1 28 3
MARK1 31 14
EIF2AK3 31 0
EPH-A2 32 26
JNK2 33 1
MSK1 34 4
BRSK2 35 7
IRR 35 3
PDK1 36 3
JNK1 38 0
CSK 38 15
TLK1 39 0
JNK3 39 0
MPSK1 42 5
PKD1 48 6
IKK beta 55 6
GCK 56 22
PKC alpha 56 9
ERK2 57 5
MINK1 57 5
NEK6 59 5
SGK1 61 1
MST2 61 39
PIM1 62 0
PIM3 63 4
TTK 64 4
MST4 67 2
p38 delta MAPK 68 2
CK1 delta 69 8
OSR1 71 4
PKC gamma 71 19
SmMLCK 72 11
LKB1 73 2
TAO1 74 8
MKK6 75 4
PKB beta 77 0
ASK1 77 5
PKC zeta 78 5
MAPKAP-K3 81 12
ERK1 82 0
PRAK 85 1
p38 alpha MAPK 85 12
SRPK1 87 1
PKB alpha 89 7
EF2K 91 5
PLK1 91 7
MEKK1 92 9
p38 beta MAPK 95 14
p38 gamma MAPK 95 1
TTBK1 102 8
PIM2 106 6
MAPKAP-K2 108 5
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
JAK2 4 0
VEGFR1 5 1
Src 7 1
MLK1 7 1
EPH-B1 8 0
Lck 10 2
TAK1 14 3
EPH-A4 14 0
TBK1 14 0
MLK3 15 5
YES1 16 9
NUAK1 16 2
Aurora A 18 3
IRAK1 19 3
FGF-R1 20 1
BTK 22 2
ERK8 22 6
NEK2a 22 2
EPH-B2 23 11
AMPK 25 4
EPH-A2 28 12
RIPK2 28 5
IKK epsilon 28 6
PAK4 29 1
GCK 29 9
STK33 30 2
CLK2 30 10
TSSK1 31 7
HIPK2 31 11
ABL 31 2
TrkA 32 4
CK2 33 2
CDK2-Cyclin A 34 2
Aurora B 36 1
GSK3 beta 37 6
MELK 37 0
RSK2 38 1
MKK1 40 8
MARK3 41 9
HIPK1 44 13
BRK 46 4
CHK2 48 0
ROCK 2 49 5
DYRK2 50 5
PAK2 50 14
DAPK1 51 5
PAK5 53 0
ZAP70 54 1
MKK2 55 7
PHK 56 1
DYRK1A 57 3
PRK2 57 3
SYK 58 7
CAMKK beta 58 4
TESK1 59 10
MNK1 59 5
TIE2 60 4
HER4 60 4
RSK1 62 44
PAK6 62 8
MARK1 63 6
IRAK4 64 11
CSK 65 5
JNK3 65 13
MNK2 67 9
MARK2 67 4
CAMK1 67 2
HIPK3 69 12
EPH-B4 69 13
S6K1 70 15
CHK1 72 0
BRSK1 74 2
DYRK3 75 30
MSK1 76 8
IRR 78 9
MST2 78 5
PKA 78 11
TLK1 79 1
IR 79 4
TTK 81 1
ERK2 84 13
BRSK2 84 5
JNK2 85 21
IKK beta 86 8
EPH-B3 86 16
PKB beta 88 17
NEK6 89 2
JNK1 89 13
EIF2AK3 90 20
PLK1 90 11
MST4 90 18
PIM3 91 6
MARK4 92 24
p38 delta MAPK 93 21
PKC zeta 94 21
CK1 delta 95 1
TAO1 95 7
PKC alpha 95 15
PDK1 96 4
PIM1 96 17
MAPKAP-K3 97 3
PRAK 98 12
p38 alpha MAPK 98 4
ASK1 99 3
PKB alpha 99 12
MKK6 99 5
EF2K 100 13
PKD1 100 0
SmMLCK 100 6
OSR1 101 14
MPSK1 101 1
p38 beta MAPK 103 2
MEKK1 103 7
TTBK1 104 11
MINK1 104 14
IGF-1R 104 19
SRPK1 104 4
MAPKAP-K2 105 25
SGK1 107 10
PIM2 108 16
ERK1 111 12
p38 gamma MAPK 113 16
PKC gamma 117 7
LKB1 119 14

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