Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Amgen TBK 1 inhibitor (Compound II) C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470 Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 40 8
MKK2 55 7
MKK6 99 5
ERK1 111 12
ERK2 84 13
JNK1 89 13
JNK2 85 21
JNK3 65 13
p38 alpha MAPK 98 4
p38 beta MAPK 103 2
p38 gamma MAPK 113 16
p38 delta MAPK 93 21
ERK8 22 6
RSK1 62 44
RSK2 38 1
PDK1 96 4
PKB alpha 99 12
PKB beta 88 17
SGK1 107 10
S6K1 70 15
PKA 78 11
ROCK 2 49 5
PRK2 57 3
PKC alpha 95 15
PKC gamma 117 7
PKC zeta 94 21
PKD1 100 0
STK33 30 2
MSK1 76 8
MNK1 59 5
MNK2 67 9
MAPKAP-K2 105 25
MAPKAP-K3 97 3
PRAK 98 12
CAMKK beta 58 4
CAMK1 67 2
SmMLCK 100 6
PHK 56 1
DAPK1 51 5
CHK1 72 0
CHK2 48 0
GSK3 beta 37 6
CDK2-Cyclin A 34 2
PLK1 90 11
Aurora A 18 3
Aurora B 36 1
TLK1 79 1
LKB1 119 14
AMPK 25 4
MARK1 63 6
MARK2 67 4
MARK3 41 9
MARK4 92 24
BRSK1 74 2
BRSK2 84 5
MELK 37 0
NUAK1 16 2
TSSK1 31 7
CK1 delta 95 1
CK2 33 2
TTBK1 104 11
DYRK1A 57 3
DYRK2 50 5
DYRK3 75 30
NEK2a 22 2
NEK6 89 2
IKK beta 86 8
IKK epsilon 28 6
TBK1 14 0
PIM1 96 17
PIM2 108 16
PIM3 91 6
SRPK1 104 4
EF2K 100 13
EIF2AK3 90 20
HIPK1 44 13
HIPK2 31 11
HIPK3 69 12
CLK2 30 10
PAK2 50 14
PAK4 29 1
PAK5 53 0
PAK6 62 8
MST2 78 5
MST4 90 18
GCK 29 9
MINK1 104 14
MEKK1 103 7
MLK1 7 1
MLK3 15 5
TESK1 59 10
TAO1 95 7
ASK1 99 3
TAK1 14 3
IRAK1 19 3
IRAK4 64 11
RIPK2 28 5
OSR1 101 14
TTK 81 1
MPSK1 101 1
Src 7 1
Lck 10 2
CSK 65 5
YES1 16 9
ABL 31 2
BTK 22 2
JAK2 4 0
SYK 58 7
ZAP70 54 1
TIE2 60 4
BRK 46 4
EPH-A2 28 12
EPH-A4 14 0
EPH-B1 8 0
EPH-B2 23 11
EPH-B3 86 16
EPH-B4 69 13
FGF-R1 20 1
HER4 60 4
IGF-1R 104 19
IR 79 4
IRR 78 9
TrkA 32 4
VEGFR1 5 1
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 13 2
MKK2 28 4
MKK6 75 4
ERK1 82 0
ERK2 57 5
JNK1 38 0
JNK2 33 1
JNK3 39 0
p38 alpha MAPK 85 12
p38 beta MAPK 95 14
p38 gamma MAPK 95 1
p38 delta MAPK 68 2
ERK8 4 1
RSK1 7 0
RSK2 9 1
PDK1 36 3
PKB alpha 89 7
PKB beta 77 0
SGK1 61 1
S6K1 28 3
PKA 26 5
ROCK 2 25 5
PRK2 27 4
PKC alpha 56 9
PKC gamma 71 19
PKC zeta 78 5
PKD1 48 6
STK33 23 3
MSK1 34 4
MNK1 17 0
MNK2 17 5
MAPKAP-K2 108 5
MAPKAP-K3 81 12
PRAK 85 1
CAMKK beta 28 1
CAMK1 26 2
SmMLCK 72 11
PHK 12 1
DAPK1 15 1
CHK1 20 1
CHK2 12 2
GSK3 beta 6 1
CDK2-Cyclin A 7 1
PLK1 91 7
Aurora A 3 1
Aurora B 11 3
TLK1 39 0
LKB1 73 2
AMPK 22 0
MARK1 31 14
MARK2 28 9
MARK3 16 1
MARK4 24 5
BRSK1 17 1
BRSK2 35 7
MELK 27 4
NUAK1 13 1
TSSK1 5 0
CK1 delta 69 8
CK2 6 5
TTBK1 102 8
DYRK1A 12 1
DYRK2 16 2
DYRK3 10 2
NEK2a 3 1
NEK6 59 5
IKK beta 55 6
IKK epsilon 18 4
TBK1 8 1
PIM1 62 0
PIM2 106 6
PIM3 63 4
SRPK1 87 1
EF2K 91 5
EIF2AK3 31 0
HIPK1 17 4
HIPK2 10 1
HIPK3 19 0
CLK2 11 4
PAK2 14 1
PAK4 9 0
PAK5 18 0
PAK6 24 2
MST2 61 39
MST4 67 2
GCK 56 22
MINK1 57 5
MEKK1 92 9
MLK1 6 0
MLK3 8 0
TESK1 24 5
TAO1 74 8
ASK1 77 5
TAK1 19 12
IRAK1 5 2
IRAK4 20 1
RIPK2 14 1
OSR1 71 4
TTK 64 4
MPSK1 42 5
Src 3 0
Lck 4 0
CSK 38 15
YES1 7 2
ABL 7 3
BTK 14 1
JAK2 3 1
SYK 13 0
ZAP70 22 4
TIE2 11 4
BRK 6 1
EPH-A2 32 26
EPH-A4 5 1
EPH-B1 3 1
EPH-B2 6 2
EPH-B3 16 4
EPH-B4 3 0
FGF-R1 8 4
HER4 17 1
IGF-1R 6 1
IR 21 7
IRR 35 3
TrkA 11 1
VEGFR1 2 0

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