Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GW843682X (GSK-PLK1 Compound 2) C22H18F3N3O4S 477.46 PLK1 Emmitte K.A. (2009) Bioorganic and Medicinal Chemistry Letters 19 1018-1021 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
Aurora B 3 1
PLK1 4 2
NUAK1 7 3
BRSK1 7 1
MST2 12 1
PRK2 12 2
ERK8 13 4
SIK2 14 1
RIPK2 14 2
FGF-R1 17 1
MEKK1 17 2
VEGFR1 17 2
BRSK2 18 3
NEK2a 18 2
MLK3 20 2
GCK 24 2
Lck 24 3
SIK3 26 1
MLK1 26 10
TIE2 26 2
PIM3 27 3
CHK2 30 14
DAPK1 31 3
CLK2 32 3
SmMLCK 32 3
MARK3 36 11
DYRK2 37 4
BTK 38 2
ASK1 39 8
DYRK3 40 15
GSK3 beta 41 2
PIM1 41 9
CSK 42 1
RSK2 42 2
TAK1 42 6
TrkA 45 4
Src 48 4
AMPK 48 11
IRAK4 49 7
MELK 50 0
YES1 50 6
MSK1 51 5
EPH-B1 53 1
MINK1 53 28
TSSK1 53 4
RSK1 54 40
MAPKAP-K3 54 4
HIPK2 54 7
PKB beta 54 2
IRAK1 55 14
EPH-A2 55 0
EPH-A4 55 2
CDK2-Cyclin A 56 8
ABL 58 7
JAK2 58 6
STK33 59 14
Aurora A 60 11
CAMKK beta 61 46
MARK4 61 16
TBK1 63 13
ROCK 2 64 5
NEK6 64 2
JNK3 65 12
PDK1 66 7
MAPKAP-K2 66 5
MKK1 66 9
CDK9-Cyclin T1 67 3
IR 68 1
TESK1 69 7
JNK1 69 6
LKB1 70 12
SYK 71 1
MARK1 71 27
TAO1 72 4
OSR1 72 9
SRPK1 73 9
CK1 delta 73 8
MARK2 73 5
PAK4 73 1
PHK 73 1
WNK1 74 6
PKD1 74 21
MKK2 74 6
S6K1 75 20
PAK6 75 3
CHK1 77 4
HER4 77 12
IRR 77 18
DDR2 77 12
PRAK 78 9
MKK6 78 0
PAK5 78 6
p38 beta MAPK 79 0
TTK 80 10
SGK1 80 8
IKK beta 81 1
p38 alpha MAPK 82 1
EPH-B2 82 1
JNK2 82 11
MNK1 84 15
DYRK1A 84 1
HIPK3 84 7
IKK epsilon 86 15
MNK2 86 10
PKC gamma 87 5
MPSK1 87 15
CK2 87 12
TTBK1 87 12
EPH-B4 89 12
ZAP70 89 13
CAMK1 89 2
p38 gamma MAPK 90 2
IGF-1R 90 7
BRK 90 10
PKC zeta 91 4
CK1 gamma 2 91 1
ERK1 91 1
PKA 92 8
ERK2 93 2
PKB alpha 94 2
PIM2 96 11
EIF2AK3 96 11
EF2K 97 1
TLK1 97 4
HIPK1 98 4
PKC alpha 100 1
EPH-B3 100 3
p38 delta MAPK 105 4
PAK2 124 20
MST3 138 86
MST4 278 15
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PLK1 5 2
NUAK1 9 2
Aurora B 16 2
BRSK1 18 1
PRK2 22 2
MST2 22 3
NEK2a 23 3
BRSK2 23 1
ERK8 26 9
SIK2 27 0
RIPK2 29 0
MEKK1 29 3
FGF-R1 32 1
VEGFR1 33 2
PIM3 38 14
MLK3 42 4
MLK1 43 2
MINK1 45 4
CHK2 46 2
SIK3 47 5
GCK 48 3
MARK3 49 7
CAMKK beta 49 0
CLK2 50 2
TBK1 53 9
RSK1 53 11
Lck 54 3
DYRK2 54 3
DYRK3 56 6
TIE2 56 10
SmMLCK 57 1
RSK2 57 9
GSK3 beta 59 1
Src 61 6
BTK 62 1
AMPK 62 7
IRAK4 64 10
DAPK1 68 2
EPH-A4 69 7
STK33 69 13
YES1 69 7
PIM1 70 5
TSSK1 70 4
CSK 70 6
TAK1 70 1
MARK1 71 0
TrkA 72 7
MARK4 73 12
MELK 74 0
MKK1 74 6
MAPKAP-K3 74 7
ASK1 74 9
ERK2 75 7
TAO1 75 9
JAK2 75 2
SRPK1 76 4
MAPKAP-K2 76 2
IRR 76 15
DYRK1A 76 3
PAK5 77 1
IKK epsilon 77 6
CDK2-Cyclin A 77 7
MKK6 77 2
CHK1 79 12
CK1 delta 79 10
IR 81 9
HIPK2 81 2
MKK2 81 11
S6K1 81 2
JNK1 82 9
TTK 82 6
PKD1 82 11
PKB alpha 82 4
JNK3 83 2
EPH-A2 84 2
PDK1 84 5
CK1 gamma 2 85 1
NEK6 86 5
PAK6 86 2
EPH-B1 86 4
MST3 86 7
ABL 86 6
PKB beta 86 3
ERK1 86 5
IKK beta 87 7
HER4 87 0
PAK2 87 2
p38 alpha MAPK 88 5
TESK1 88 1
MSK1 89 1
PHK 90 8
MNK2 90 2
PKC zeta 91 11
EIF2AK3 91 6
JNK2 92 11
ROCK 2 93 1
CDK9-Cyclin T1 93 4
HIPK3 93 8
CAMK1 93 0
MPSK1 94 1
EF2K 94 1
WNK1 95 2
HIPK1 95 2
TTBK1 95 3
PRAK 95 6
PAK4 96 1
EPH-B2 96 6
CK2 96 3
DDR2 96 0
IRAK1 96 15
Aurora A 97 5
MARK2 97 12
PIM2 98 12
p38 beta MAPK 99 4
MNK1 99 1
OSR1 100 7
EPH-B3 100 3
ZAP70 100 6
PKA 101 4
BRK 101 5
p38 gamma MAPK 102 3
SGK1 103 10
EPH-B4 104 3
p38 delta MAPK 104 0
LKB1 104 6
SYK 105 1
PKC alpha 106 4
TLK1 109 4
PKC gamma 111 0
IGF-1R 118 3
MST4 159 14
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
PLK1 7 2
NUAK1 44 4
MST2 52 6
Aurora B 57 1
MEKK1 65 13
PRK2 66 7
BRSK1 67 2
NEK2a 70 12
BRSK2 71 3
VEGFR1 75 10
MINK1 76 8
RIPK2 77 5
ERK8 77 3
CAMKK beta 79 6
CK1 gamma 2 79 3
CK1 delta 80 1
MLK3 81 2
SIK2 83 2
MST4 84 3
MARK1 85 3
MARK3 85 1
CHK2 85 12
GSK3 beta 85 0
CSK 85 4
MLK1 85 1
MAPKAP-K2 85 7
SmMLCK 87 5
SIK3 87 5
IR 87 2
AMPK 88 4
EPH-A4 88 4
MAPKAP-K3 88 5
MKK2 89 5
DYRK2 89 0
IRAK4 89 6
SRPK1 89 2
TAO1 89 15
PRAK 90 1
TIE2 90 6
EPH-B1 90 6
Src 91 4
FGF-R1 91 6
BTK 91 2
CLK2 92 12
JNK1 92 9
PHK 92 5
IKK beta 92 3
PKB beta 93 3
ZAP70 93 11
PAK2 93 7
PIM1 93 7
GCK 94 4
TrkA 94 10
ERK2 95 8
TBK1 95 8
MKK6 96 3
ERK1 96 9
S6K1 96 8
PAK4 96 8
ROCK 2 96 6
CDK2-Cyclin A 96 6
STK33 96 4
PIM3 96 15
MSK1 96 9
RSK1 96 2
ASK1 97 8
TAK1 97 8
PKD1 97 8
CDK9-Cyclin T1 97 1
MKK1 97 6
NEK6 98 4
TSSK1 98 0
Aurora A 98 5
EIF2AK3 98 13
PKB alpha 98 2
TTBK1 98 10
DYRK1A 99 1
DYRK3 99 5
JNK2 99 7
MST3 99 10
WNK1 99 1
EF2K 99 6
PAK5 100 5
IKK epsilon 100 2
p38 beta MAPK 100 13
EPH-B3 100 3
PKA 101 3
OSR1 101 5
HER4 101 11
IGF-1R 101 8
MARK2 102 8
PIM2 102 9
ABL 102 6
PDK1 102 5
TESK1 102 6
JAK2 102 4
Lck 103 3
DAPK1 104 2
JNK3 104 2
p38 alpha MAPK 104 11
MELK 104 7
p38 delta MAPK 104 4
RSK2 104 15
IRR 104 6
DDR2 105 1
TTK 105 8
MPSK1 105 11
CK2 105 8
HIPK3 106 4
CAMK1 106 2
EPH-A2 106 13
MNK1 106 3
PKC gamma 107 13
p38 gamma MAPK 107 7
EPH-B4 107 4
MNK2 107 10
TLK1 108 13
LKB1 108 5
HIPK2 108 2
YES1 109 7
SGK1 110 9
IRAK1 110 3
PAK6 110 0
CHK1 110 2
PKC zeta 110 10
HIPK1 111 10
MARK4 115 3
PKC alpha 116 3
BRK 122 2
EPH-B2 123 15
SYK 125 0

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