Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
GW843682X (GSK-PLK1 Compound 2) C22H18F3N3O4S 477.46 PLK1 Emmitte K.A. (2009) Bioorganic and Medicinal Chemistry Letters 19 1018-1021 Tocris Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 66 9
MKK2 74 6
MKK6 78 0
ERK1 91 1
ERK2 93 2
JNK1 69 6
JNK2 82 11
JNK3 65 12
p38 alpha MAPK 82 1
p38 beta MAPK 79 0
p38 gamma MAPK 90 2
p38 delta MAPK 105 4
ERK8 13 4
RSK1 54 40
RSK2 42 2
PDK1 66 7
PKB alpha 94 2
PKB beta 54 2
SGK1 80 8
S6K1 75 20
PKA 92 8
ROCK 2 64 5
PRK2 12 2
PKC alpha 100 1
PKC gamma 87 5
PKC zeta 91 4
PKD1 74 21
STK33 59 14
MSK1 51 5
MNK1 84 15
MNK2 86 10
MAPKAP-K2 66 5
MAPKAP-K3 54 4
PRAK 78 9
CAMKK beta 61 46
CAMK1 89 2
SmMLCK 32 3
PHK 73 1
DAPK1 31 3
CHK1 77 4
CHK2 30 14
GSK3 beta 41 2
CDK2-Cyclin A 56 8
CDK9-Cyclin T1 67 3
PLK1 4 2
Aurora A 60 11
Aurora B 3 1
TLK1 97 4
LKB1 70 12
AMPK 48 11
MARK1 71 27
MARK2 73 5
MARK3 36 11
MARK4 61 16
BRSK1 7 1
BRSK2 18 3
MELK 50 0
NUAK1 7 3
SIK2 14 1
SIK3 26 1
TSSK1 53 4
CK1 gamma 2 91 1
CK1 delta 73 8
CK2 87 12
TTBK1 87 12
DYRK1A 84 1
DYRK2 37 4
DYRK3 40 15
NEK2a 18 2
NEK6 64 2
IKK beta 81 1
IKK epsilon 86 15
TBK1 63 13
PIM1 41 9
PIM2 96 11
PIM3 27 3
SRPK1 73 9
EF2K 97 1
EIF2AK3 96 11
HIPK1 98 4
HIPK2 54 7
HIPK3 84 7
CLK2 32 3
PAK2 124 20
PAK4 73 1
PAK5 78 6
PAK6 75 3
MST2 12 1
MST3 138 86
MST4 278 15
GCK 24 2
MINK1 53 28
MEKK1 17 2
MLK1 26 10
MLK3 20 2
TESK1 69 7
TAO1 72 4
ASK1 39 8
TAK1 42 6
IRAK1 55 14
IRAK4 49 7
RIPK2 14 2
OSR1 72 9
TTK 80 10
MPSK1 87 15
WNK1 74 6
Src 48 4
Lck 24 3
CSK 42 1
YES1 50 6
ABL 58 7
BTK 38 2
JAK2 58 6
SYK 71 1
ZAP70 89 13
TIE2 26 2
BRK 90 10
EPH-A2 55 0
EPH-A4 55 2
EPH-B1 53 1
EPH-B2 82 1
EPH-B3 100 3
EPH-B4 89 12
FGF-R1 17 1
HER4 77 12
IGF-1R 90 7
IR 68 1
IRR 77 18
TrkA 45 4
DDR2 77 12
VEGFR1 17 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 74 6
MKK2 81 11
MKK6 77 2
ERK1 86 5
ERK2 75 7
JNK1 82 9
JNK2 92 11
JNK3 83 2
p38 alpha MAPK 88 5
p38 beta MAPK 99 4
p38 gamma MAPK 102 3
p38 delta MAPK 104 0
ERK8 26 9
RSK1 53 11
RSK2 57 9
PDK1 84 5
PKB alpha 82 4
PKB beta 86 3
SGK1 103 10
S6K1 81 2
PKA 101 4
ROCK 2 93 1
PRK2 22 2
PKC alpha 106 4
PKC gamma 111 0
PKC zeta 91 11
PKD1 82 11
STK33 69 13
MSK1 89 1
MNK1 99 1
MNK2 90 2
MAPKAP-K2 76 2
MAPKAP-K3 74 7
PRAK 95 6
CAMKK beta 49 0
CAMK1 93 0
SmMLCK 57 1
PHK 90 8
DAPK1 68 2
CHK1 79 12
CHK2 46 2
GSK3 beta 59 1
CDK2-Cyclin A 77 7
CDK9-Cyclin T1 93 4
PLK1 5 2
Aurora A 97 5
Aurora B 16 2
TLK1 109 4
LKB1 104 6
AMPK 62 7
MARK1 71 0
MARK2 97 12
MARK3 49 7
MARK4 73 12
BRSK1 18 1
BRSK2 23 1
MELK 74 0
NUAK1 9 2
SIK2 27 0
SIK3 47 5
TSSK1 70 4
CK1 gamma 2 85 1
CK1 delta 79 10
CK2 96 3
TTBK1 95 3
DYRK1A 76 3
DYRK2 54 3
DYRK3 56 6
NEK2a 23 3
NEK6 86 5
IKK beta 87 7
IKK epsilon 77 6
TBK1 53 9
PIM1 70 5
PIM2 98 12
PIM3 38 14
SRPK1 76 4
EF2K 94 1
EIF2AK3 91 6
HIPK1 95 2
HIPK2 81 2
HIPK3 93 8
CLK2 50 2
PAK2 87 2
PAK4 96 1
PAK5 77 1
PAK6 86 2
MST2 22 3
MST3 86 7
MST4 159 14
GCK 48 3
MINK1 45 4
MEKK1 29 3
MLK1 43 2
MLK3 42 4
TESK1 88 1
TAO1 75 9
ASK1 74 9
TAK1 70 1
IRAK1 96 15
IRAK4 64 10
RIPK2 29 0
OSR1 100 7
TTK 82 6
MPSK1 94 1
WNK1 95 2
Src 61 6
Lck 54 3
CSK 70 6
YES1 69 7
ABL 86 6
BTK 62 1
JAK2 75 2
SYK 105 1
ZAP70 100 6
TIE2 56 10
BRK 101 5
EPH-A2 84 2
EPH-A4 69 7
EPH-B1 86 4
EPH-B2 96 6
EPH-B3 100 3
EPH-B4 104 3
FGF-R1 32 1
HER4 87 0
IGF-1R 118 3
IR 81 9
IRR 76 15
TrkA 72 7
DDR2 96 0
VEGFR1 33 2
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 97 6
MKK2 89 5
MKK6 96 3
ERK1 96 9
ERK2 95 8
JNK1 92 9
JNK2 99 7
JNK3 104 2
p38 alpha MAPK 104 11
p38 beta MAPK 100 13
p38 gamma MAPK 107 7
p38 delta MAPK 104 4
ERK8 77 3
RSK1 96 2
RSK2 104 15
PDK1 102 5
PKB alpha 98 2
PKB beta 93 3
SGK1 110 9
S6K1 96 8
PKA 101 3
ROCK 2 96 6
PRK2 66 7
PKC alpha 116 3
PKC gamma 107 13
PKC zeta 110 10
PKD1 97 8
STK33 96 4
MSK1 96 9
MNK1 106 3
MNK2 107 10
MAPKAP-K2 85 7
MAPKAP-K3 88 5
PRAK 90 1
CAMKK beta 79 6
CAMK1 106 2
SmMLCK 87 5
PHK 92 5
DAPK1 104 2
CHK1 110 2
CHK2 85 12
GSK3 beta 85 0
CDK2-Cyclin A 96 6
CDK9-Cyclin T1 97 1
PLK1 7 2
Aurora A 98 5
Aurora B 57 1
TLK1 108 13
LKB1 108 5
AMPK 88 4
MARK1 85 3
MARK2 102 8
MARK3 85 1
MARK4 115 3
BRSK1 67 2
BRSK2 71 3
MELK 104 7
NUAK1 44 4
SIK2 83 2
SIK3 87 5
TSSK1 98 0
CK1 gamma 2 79 3
CK1 delta 80 1
CK2 105 8
TTBK1 98 10
DYRK1A 99 1
DYRK2 89 0
DYRK3 99 5
NEK2a 70 12
NEK6 98 4
IKK beta 92 3
IKK epsilon 100 2
TBK1 95 8
PIM1 93 7
PIM2 102 9
PIM3 96 15
SRPK1 89 2
EF2K 99 6
EIF2AK3 98 13
HIPK1 111 10
HIPK2 108 2
HIPK3 106 4
CLK2 92 12
PAK2 93 7
PAK4 96 8
PAK5 100 5
PAK6 110 0
MST2 52 6
MST3 99 10
MST4 84 3
GCK 94 4
MINK1 76 8
MEKK1 65 13
MLK1 85 1
MLK3 81 2
TESK1 102 6
TAO1 89 15
ASK1 97 8
TAK1 97 8
IRAK1 110 3
IRAK4 89 6
RIPK2 77 5
OSR1 101 5
TTK 105 8
MPSK1 105 11
WNK1 99 1
Src 91 4
Lck 103 3
CSK 85 4
YES1 109 7
ABL 102 6
BTK 91 2
JAK2 102 4
SYK 125 0
ZAP70 93 11
TIE2 90 6
BRK 122 2
EPH-A2 106 13
EPH-A4 88 4
EPH-B1 90 6
EPH-B2 123 15
EPH-B3 100 3
EPH-B4 107 4
FGF-R1 91 6
HER4 101 11
IGF-1R 101 8
IR 87 2
IRR 104 6
TrkA 94 10
DDR2 105 1
VEGFR1 75 10

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