Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Novartis 12a (PKD1) C23H29F3N6O3 494.51 PKD1 Meredith E.L. (2010) J.Med.Chem. 53 5422-5438 Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 86 3
MKK2 106 4
MKK6 92 8
ERK1 78 10
ERK2 36 19
JNK1 109 15
JNK2 91 1
JNK3 88 13
p38 alpha MAPK 104 0
p38 beta MAPK 99 0
p38 gamma MAPK 95 11
p38 delta MAPK 89 2
ERK8 63 7
RSK1 88 12
RSK2 98 8
PDK1 94 13
PKB alpha 109 2
PKB beta 97 14
SGK1 63 64
S6K1 92 0
PKA 105 10
ROCK 2 99 4
PRK2 96 6
PKC alpha 97 19
PKC gamma 106 2
PKC zeta 88 8
PKD1 6 3
STK33 103 16
MSK1 97 11
MNK1 95 9
MNK2 76 6
MAPKAP-K2 99 14
MAPKAP-K3 92 1
PRAK 109 3
CAMKK beta 85 17
CAMK1 81 3
SmMLCK 85 14
PHK 82 7
DAPK1 102 1
CHK1 115 34
CHK2 102 1
GSK3 beta 86 3
CDK2-Cyclin A 66 7
PLK1 101 9
Aurora A 92 7
Aurora B 132 19
TLK1 91 8
LKB1 77 2
AMPK 97 17
MARK1 51 13
MARK2 97 11
MARK3 92 17
MARK4 87 4
BRSK1 96 15
BRSK2 67 8
MELK 108 7
NUAK1 59 22
TSSK1 84 10
CK1 delta 75 17
CK2 107 2
TTBK1 93 8
DYRK1A 97 1
DYRK2 74 11
DYRK3 39 4
NEK2a 111 6
NEK6 86 10
IKK beta 85 1
IKK epsilon 98 8
TBK1 100 20
PIM1 114 5
PIM2 99 1
PIM3 97 1
SRPK1 105 10
EF2K 105 8
EIF2AK3 108 12
HIPK1 99 10
HIPK2 89 8
HIPK3 95 5
CLK2 78 8
PAK2 105 10
PAK4 101 11
PAK5 97 0
PAK6 99 5
MST2 103 4
MST4 117 2
GCK 41 4
MINK1 65 4
MEKK1 115 8
MLK1 81 25
MLK3 93 2
TESK1 99 7
TAO1 103 7
ASK1 98 9
TAK1 94 2
IRAK1 92 1
IRAK4 96 7
RIPK2 96 13
OSR1 98 3
TTK 111 14
MPSK1 100 4
Src 106 8
Lck 84 8
CSK 113 11
YES1 107 6
ABL 102 11
BTK 92 2
JAK2 82 7
SYK 90 2
ZAP70 108 14
TIE2 101 4
BRK 114 1
EPH-A2 78 13
EPH-A4 90 12
EPH-B1 96 8
EPH-B2 105 10
EPH-B3 105 3
EPH-B4 103 6
FGF-R1 110 7
HER4 83 6
IGF-1R 97 7
IR 89 5
IRR 100 13
TrkA 72 1
VEGFR1 95 12
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 77 18
MKK2 123 2
MKK6 29 6
ERK1 34 3
ERK2 29 1
JNK1 100 8
JNK2 94 32
JNK3 79 8
p38 alpha MAPK 116 13
p38 beta MAPK 96 7
p38 gamma MAPK 96 5
p38 delta MAPK 93 7
ERK8 26 2
RSK1 53 9
RSK2 110 22
PDK1 114 28
PKB alpha 106 8
PKB beta 57 11
SGK1 104 25
S6K1 96 1
PKA 109 8
ROCK 2 108 26
PRK2 66 3
PKC alpha 95 15
PKC gamma 103 7
PKC zeta 109 3
PKD1 5 2
STK33 83 22
MSK1 109 12
MNK1 38 3
MNK2 31 2
MAPKAP-K2 72 12
MAPKAP-K3 100 16
PRAK 97 1
CAMKK beta 99 3
CAMK1 20 5
SmMLCK 40 4
PHK 29 1
DAPK1 93 16
CHK1 100 12
CHK2 106 16
GSK3 beta 82 14
CDK2-Cyclin A 30 5
PLK1 117 3
Aurora A 88 7
Aurora B 117 0
TLK1 107 9
LKB1 96 24
AMPK 61 9
MARK1 94 19
MARK2 63 4
MARK3 40 7
MARK4 46 9
BRSK1 73 10
BRSK2 26 4
MELK 78 17
NUAK1 17 5
TSSK1 56 1
CK1 delta 42 6
CK2 110 19
TTBK1 128 28
DYRK1A 63 7
DYRK2 29 2
DYRK3 14 12
NEK2a 129 8
NEK6 87 8
IKK beta 50 1
IKK epsilon 87 13
TBK1 88 9
PIM1 98 14
PIM2 102 5
PIM3 58 1
SRPK1 86 5
EF2K 111 11
EIF2AK3 101 2
HIPK1 99 1
HIPK2 125 1
HIPK3 92 1
CLK2 70 22
PAK2 93 1
PAK4 93 6
PAK5 90 1
PAK6 99 7
MST2 110 1
MST4 107 4
GCK 82 6
MINK1 13 1
MEKK1 114 27
MLK1 69 3
MLK3 86 10
TESK1 102 3
TAO1 113 22
ASK1 84 3
TAK1 100 5
IRAK1 102 21
IRAK4 127 16
RIPK2 96 3
OSR1 104 6
TTK 87 0
MPSK1 93 6
Src 90 7
Lck 30 7
CSK 116 3
YES1 94 6
ABL 112 5
BTK 120 4
JAK2 87 4
SYK 104 6
ZAP70 114 17
TIE2 111 9
BRK 124 15
EPH-A2 99 1
EPH-A4 78 4
EPH-B1 111 7
EPH-B2 129 26
EPH-B3 124 15
EPH-B4 84 23
FGF-R1 85 13
HER4 99 23
IGF-1R 102 12
IR 86 5
IRR 107 6
TrkA 68 22
VEGFR1 88 13
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 49 1
MKK2 115 2
MKK6 16 3
ERK1 10 2
ERK2 6 2
JNK1 38 18
JNK2 35 4
JNK3 31 4
p38 alpha MAPK 103 3
p38 beta MAPK 62 9
p38 gamma MAPK 58 2
p38 delta MAPK 50 1
ERK8 4 2
RSK1 2 2
RSK2 81 1
PDK1 107 14
PKB alpha 94 11
PKB beta 3 1
SGK1 90 13
S6K1 94 8
PKA 93 14
ROCK 2 51 1
PRK2 19 1
PKC alpha 90 0
PKC gamma 115 10
PKC zeta 84 10
PKD1 5 0
STK33 66 0
MSK1 79 3
MNK1 7 5
MNK2 6 2
MAPKAP-K2 22 1
MAPKAP-K3 92 12
PRAK 65 11
CAMKK beta 62 17
CAMK1 1 0
SmMLCK 10 5
PHK 5 1
DAPK1 40 10
CHK1 70 1
CHK2 88 10
GSK3 beta 51 7
CDK2-Cyclin A 11 2
PLK1 111 1
Aurora A 112 8
Aurora B 115 14
TLK1 90 11
LKB1 71 6
AMPK 20 3
MARK1 76 9
MARK2 31 4
MARK3 15 4
MARK4 10 4
BRSK1 26 1
BRSK2 8 2
MELK 40 8
NUAK1 32 4
TSSK1 12 3
CK1 delta 18 2
CK2 65 1
TTBK1 93 5
DYRK1A 21 2
DYRK2 10 5
DYRK3 7 5
NEK2a 113 1
NEK6 42 5
IKK beta 23 4
IKK epsilon 48 9
TBK1 30 1
PIM1 65 7
PIM2 99 8
PIM3 42 4
SRPK1 46 5
EF2K 87 5
EIF2AK3 97 1
HIPK1 106 2
HIPK2 87 14
HIPK3 101 11
CLK2 51 8
PAK2 57 3
PAK4 74 3
PAK5 71 4
PAK6 81 9
MST2 98 0
MST4 95 1
GCK 44 1
MINK1 2 1
MEKK1 102 13
MLK1 103 12
MLK3 81 4
TESK1 93 9
TAO1 53 2
ASK1 21 5
TAK1 55 1
IRAK1 87 3
IRAK4 92 4
RIPK2 79 1
OSR1 73 6
TTK 79 7
MPSK1 84 12
Src 66 14
Lck 9 1
CSK 90 11
YES1 76 12
ABL 100 5
BTK 79 10
JAK2 89 6
SYK 92 10
ZAP70 109 1
TIE2 84 4
BRK 103 2
EPH-A2 82 10
EPH-A4 48 9
EPH-B1 99 1
EPH-B2 113 29
EPH-B3 94 5
EPH-B4 91 3
FGF-R1 82 1
HER4 73 0
IGF-1R 99 14
IR 93 11
IRR 97 9
TrkA 71 4
VEGFR1 68 1

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