Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Merck 7 (PDK1) C28H22F2N4O4 516.5 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448 Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remainingsort descending Standard Deviation
PDK1 7 1
MLK3 46 3
MLK1 50 3
CAMK1 51 5
TAK1 54 4
GSK3 beta 64 12
Aurora B 64 12
PAK5 64 3
PAK4 67 0
CLK2 74 1
MAPKAP-K3 74 4
PKD1 75 4
Src 75 3
FGF-R1 75 10
PIM1 76 2
PKB beta 77 13
TrkA 78 19
STK33 79 10
DYRK1A 79 4
PAK2 79 6
BRSK2 79 5
SYK 82 8
DYRK2 83 9
OSR1 83 3
MARK3 83 11
MARK4 83 4
RSK2 85 1
PIM2 85 4
TSSK1 86 9
HIPK1 86 0
EPH-A2 86 14
MST4 86 17
EPH-B4 87 16
MINK1 87 17
PKC zeta 88 10
MARK2 88 5
PAK6 89 0
SmMLCK 89 4
HIPK2 90 15
MAPKAP-K2 90 14
PKB alpha 90 16
EPH-B1 90 4
CAMKK beta 90 2
HIPK3 91 0
Lck 91 11
DAPK1 91 5
ASK1 92 6
BRSK1 92 14
LKB1 93 1
DYRK3 93 4
IR 93 17
p38 delta MAPK 94 2
ERK8 94 2
GCK 94 1
CDK2-Cyclin A 95 12
MKK1 95 1
PRAK 95 5
TTK 95 0
ERK1 95 1
IKK epsilon 95 5
JNK2 95 8
CHK1 95 19
PIM3 95 10
YES1 95 5
EIF2AK3 96 2
TIE2 96 6
NEK2a 96 11
PKC alpha 96 7
RIPK2 98 7
NEK6 98 11
S6K1 98 3
HER4 98 13
NUAK1 98 16
ABL 98 4
MNK1 99 4
TLK1 99 4
AMPK 99 11
IKK beta 99 4
MELK 99 2
MST2 100 10
CHK2 100 4
JAK2 101 2
ERK2 101 2
CSK 101 9
JNK3 101 4
SRPK1 101 10
SGK1 102 5
TBK1 102 17
PKC gamma 102 31
Aurora A 103 2
PRK2 103 6
IGF-1R 103 4
IRR 105 14
p38 gamma MAPK 105 1
MSK1 106 1
TTBK1 106 7
MPSK1 106 3
EF2K 107 11
TESK1 107 6
CK2 107 13
EPH-A4 107 4
MARK1 107 6
IRAK1 108 6
MKK6 108 17
ROCK 2 108 14
BTK 110 16
IRAK4 110 26
PKA 111 4
VEGFR1 112 25
MNK2 112 14
MEKK1 112 2
CK1 delta 113 10
EPH-B3 113 18
RSK1 114 1
JNK1 114 17
p38 alpha MAPK 114 11
p38 beta MAPK 115 9
TAO1 119 4
BRK 119 0
PHK 119 22
PLK1 121 2
EPH-B2 121 17
ZAP70 128 30
MKK2 135 1
Screening Concentration: 1µM
Kinase % Activity Remainingsort descending Standard Deviation
PDK1 38 10
PKD1 80 14
EPH-B4 85 18
EPH-B1 88 4
TESK1 88 4
SYK 88 4
MKK6 89 6
ERK8 89 8
BRSK2 90 4
JNK3 90 4
PKC alpha 91 11
CDK2-Cyclin A 91 6
PAK5 92 7
CAMK1 92 1
RSK1 93 3
MARK3 93 11
CHK1 94 0
CLK2 95 18
IR 95 4
PKB beta 96 10
OSR1 96 0
GSK3 beta 96 16
HIPK2 96 9
DYRK1A 97 8
PKB alpha 97 1
NEK2a 97 8
S6K1 97 10
SmMLCK 97 14
FGF-R1 97 2
JNK2 97 6
MLK3 97 3
p38 delta MAPK 97 4
RSK2 98 8
CSK 98 6
TrkA 98 5
MNK1 99 1
AMPK 99 7
IKK beta 99 7
JAK2 99 2
TIE2 100 10
LKB1 100 11
PRAK 100 4
NEK6 100 6
TTK 100 11
ERK2 100 7
Src 100 3
MINK1 100 1
HER4 100 6
HIPK1 100 3
VEGFR1 100 3
DYRK2 101 5
MAPKAP-K2 101 14
PAK4 101 0
ERK1 101 6
GCK 101 6
Lck 101 7
EPH-A2 102 3
SGK1 102 2
MARK2 102 10
PAK6 102 4
BRSK1 102 13
MLK1 102 3
TAK1 103 5
TLK1 103 18
PKC gamma 103 11
TSSK1 103 6
EF2K 103 18
CK2 103 12
Aurora B 104 9
CAMKK beta 104 8
EIF2AK3 104 2
MSK1 104 8
RIPK2 105 9
MST2 105 4
PIM1 105 2
PIM2 105 5
YES1 105 12
IGF-1R 105 3
ABL 105 4
ASK1 105 15
CHK2 106 7
PKC zeta 106 13
ZAP70 106 3
NUAK1 107 7
STK33 107 11
PLK1 107 9
HIPK3 108 4
MARK1 108 20
JNK1 108 20
PIM3 108 11
BTK 108 1
DYRK3 109 2
PAK2 109 2
IRAK4 109 22
MAPKAP-K3 109 7
IKK epsilon 109 7
MELK 110 9
p38 beta MAPK 110 18
p38 gamma MAPK 110 0
CK1 delta 110 8
Aurora A 110 1
TTBK1 110 4
MKK1 111 32
PKA 112 7
ROCK 2 112 7
EPH-A4 113 19
PRK2 113 14
DAPK1 113 4
MEKK1 114 7
SRPK1 114 12
IRR 114 5
EPH-B2 115 21
MST4 117 8
PHK 117 19
IRAK1 118 2
MPSK1 118 17
EPH-B3 119 7
p38 alpha MAPK 121 7
MNK2 123 41
MKK2 124 4
TAO1 126 1
BRK 129 10
TBK1 132 13
MARK4 143 3
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort descending Standard Deviation
EPH-B1 87 0
PKD1 90 10
CDK2-Cyclin A 90 1
PDK1 90 10
PKC gamma 91 0
p38 delta MAPK 91 12
MINK1 92 1
STK33 92 13
ERK8 92 1
HIPK2 92 11
ERK1 93 5
JNK2 93 9
TSSK1 93 4
MKK6 94 6
EPH-A2 94 29
CAMK1 95 9
EPH-B4 95 24
EF2K 95 11
RSK1 95 17
EPH-A4 95 2
FGF-R1 96 5
CHK1 96 4
PKB alpha 96 4
OSR1 97 5
SmMLCK 97 2
MELK 97 17
GSK3 beta 97 8
TAK1 97 8
TLK1 97 2
AMPK 97 9
PKB beta 98 4
p38 gamma MAPK 98 1
TESK1 98 11
JAK2 98 1
TTK 99 0
MARK3 99 12
PKC alpha 99 5
IR 99 4
HIPK1 99 4
SYK 99 10
HIPK3 99 0
MAPKAP-K2 99 9
JNK1 100 10
PHK 100 4
p38 beta MAPK 100 1
MKK1 100 16
MPSK1 101 9
MST4 101 2
PIM1 101 4
JNK3 101 4
IRR 101 4
MSK1 101 5
TTBK1 101 10
IKK beta 102 0
PAK6 102 2
MST2 102 7
ERK2 102 1
GCK 102 7
HER4 102 7
CHK2 102 10
ZAP70 102 1
RSK2 102 5
LKB1 102 3
PAK4 102 14
RIPK2 102 2
S6K1 103 1
IKK epsilon 103 11
Src 103 13
PIM3 103 4
CK1 delta 103 9
NEK6 104 2
PAK5 104 5
YES1 104 12
PKC zeta 104 5
MLK3 104 16
TIE2 104 4
MARK2 105 5
PKA 105 1
ROCK 2 105 8
IGF-1R 105 4
Aurora B 105 16
SGK1 106 2
DAPK1 106 18
ABL 106 0
VEGFR1 106 2
MNK1 106 8
CLK2 106 6
PIM2 107 6
SRPK1 107 1
EIF2AK3 107 9
NEK2a 107 3
PRAK 108 11
PRK2 108 3
TBK1 109 16
Lck 109 9
CSK 109 13
BTK 109 1
DYRK3 109 9
MEKK1 110 12
Aurora A 110 6
ASK1 110 6
DYRK2 110 1
IRAK4 110 7
MARK1 111 20
CK2 111 1
TAO1 111 6
TrkA 113 2
DYRK1A 113 4
PAK2 113 11
EPH-B3 114 1
p38 alpha MAPK 114 7
NUAK1 115 12
MAPKAP-K3 116 1
MNK2 117 11
IRAK1 117 8
EPH-B2 118 2
BRSK1 118 1
BRSK2 118 18
PLK1 118 14
CAMKK beta 119 30
MLK1 119 16
BRK 120 15
MKK2 121 13
MARK4 150 3

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