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Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
Merck 7 (PDK1) C28H22F2N4O4 516.5 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448 Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 95 1
MKK2 135 1
MKK6 108 17
ERK1 95 1
ERK2 101 2
JNK1 114 17
JNK2 95 8
JNK3 101 4
p38 alpha MAPK 114 11
p38 beta MAPK 115 9
p38 gamma MAPK 105 1
p38 delta MAPK 94 2
ERK8 94 2
RSK1 114 1
RSK2 85 1
PDK1 7 1
PKB alpha 90 16
PKB beta 77 13
SGK1 102 5
S6K1 98 3
PKA 111 4
ROCK 2 108 14
PRK2 103 6
PKC alpha 96 7
PKC gamma 102 31
PKC zeta 88 10
PKD1 75 4
STK33 79 10
MSK1 106 1
MNK1 99 4
MNK2 112 14
MAPKAP-K2 90 14
MAPKAP-K3 74 4
PRAK 95 5
CAMKK beta 90 2
CAMK1 51 5
SmMLCK 89 4
PHK 119 22
DAPK1 91 5
CHK1 95 19
CHK2 100 4
GSK3 beta 64 12
CDK2-Cyclin A 95 12
PLK1 121 2
Aurora A 103 2
Aurora B 64 12
TLK1 99 4
LKB1 93 1
AMPK 99 11
MARK1 107 6
MARK2 88 5
MARK3 83 11
MARK4 83 4
BRSK1 92 14
BRSK2 79 5
MELK 99 2
NUAK1 98 16
TSSK1 86 9
CK1 delta 113 10
CK2 107 13
TTBK1 106 7
DYRK1A 79 4
DYRK2 83 9
DYRK3 93 4
NEK2a 96 11
NEK6 98 11
IKK beta 99 4
IKK epsilon 95 5
TBK1 102 17
PIM1 76 2
PIM2 85 4
PIM3 95 10
SRPK1 101 10
EF2K 107 11
EIF2AK3 96 2
HIPK1 86 0
HIPK2 90 15
HIPK3 91 0
CLK2 74 1
PAK2 79 6
PAK4 67 0
PAK5 64 3
PAK6 89 0
MST2 100 10
MST4 86 17
GCK 94 1
MINK1 87 17
MEKK1 112 2
MLK1 50 3
MLK3 46 3
TESK1 107 6
TAO1 119 4
ASK1 92 6
TAK1 54 4
IRAK1 108 6
IRAK4 110 26
RIPK2 98 7
OSR1 83 3
TTK 95 0
MPSK1 106 3
Src 75 3
Lck 91 11
CSK 101 9
YES1 95 5
ABL 98 4
BTK 110 16
JAK2 101 2
SYK 82 8
ZAP70 128 30
TIE2 96 6
BRK 119 0
EPH-A2 86 14
EPH-A4 107 4
EPH-B1 90 4
EPH-B2 121 17
EPH-B3 113 18
EPH-B4 87 16
FGF-R1 75 10
HER4 98 13
IGF-1R 103 4
IR 93 17
IRR 105 14
TrkA 78 19
VEGFR1 112 25
Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 100 16
MKK2 121 13
MKK6 94 6
ERK1 93 5
ERK2 102 1
JNK1 100 10
JNK2 93 9
JNK3 101 4
p38 alpha MAPK 114 7
p38 beta MAPK 100 1
p38 gamma MAPK 98 1
p38 delta MAPK 91 12
ERK8 92 1
RSK1 95 17
RSK2 102 5
PDK1 90 10
PKB alpha 96 4
PKB beta 98 4
SGK1 106 2
S6K1 103 1
PKA 105 1
ROCK 2 105 8
PRK2 108 3
PKC alpha 99 5
PKC gamma 91 0
PKC zeta 104 5
PKD1 90 10
STK33 92 13
MSK1 101 5
MNK1 106 8
MNK2 117 11
MAPKAP-K2 99 9
MAPKAP-K3 116 1
PRAK 108 11
CAMKK beta 119 30
CAMK1 95 9
SmMLCK 97 2
PHK 100 4
DAPK1 106 18
CHK1 96 4
CHK2 102 10
GSK3 beta 97 8
CDK2-Cyclin A 90 1
PLK1 118 14
Aurora A 110 6
Aurora B 105 16
TLK1 97 2
LKB1 102 3
AMPK 97 9
MARK1 111 20
MARK2 105 5
MARK3 99 12
MARK4 150 3
BRSK1 118 1
BRSK2 118 18
MELK 97 17
NUAK1 115 12
TSSK1 93 4
CK1 delta 103 9
CK2 111 1
TTBK1 101 10
DYRK1A 113 4
DYRK2 110 1
DYRK3 109 9
NEK2a 107 3
NEK6 104 2
IKK beta 102 0
IKK epsilon 103 11
TBK1 109 16
PIM1 101 4
PIM2 107 6
PIM3 103 4
SRPK1 107 1
EF2K 95 11
EIF2AK3 107 9
HIPK1 99 4
HIPK2 92 11
HIPK3 99 0
CLK2 106 6
PAK2 113 11
PAK4 102 14
PAK5 104 5
PAK6 102 2
MST2 102 7
MST4 101 2
GCK 102 7
MINK1 92 1
MEKK1 110 12
MLK1 119 16
MLK3 104 16
TESK1 98 11
TAO1 111 6
ASK1 110 6
TAK1 97 8
IRAK1 117 8
IRAK4 110 7
RIPK2 102 2
OSR1 97 5
TTK 99 0
MPSK1 101 9
Src 103 13
Lck 109 9
CSK 109 13
YES1 104 12
ABL 106 0
BTK 109 1
JAK2 98 1
SYK 99 10
ZAP70 102 1
TIE2 104 4
BRK 120 15
EPH-A2 94 29
EPH-A4 95 2
EPH-B1 87 0
EPH-B2 118 2
EPH-B3 114 1
EPH-B4 95 24
FGF-R1 96 5
HER4 102 7
IGF-1R 105 4
IR 99 4
IRR 101 4
TrkA 113 2
VEGFR1 106 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 111 32
MKK2 124 4
MKK6 89 6
ERK1 101 6
ERK2 100 7
JNK1 108 20
JNK2 97 6
JNK3 90 4
p38 alpha MAPK 121 7
p38 beta MAPK 110 18
p38 gamma MAPK 110 0
p38 delta MAPK 97 4
ERK8 89 8
RSK1 93 3
RSK2 98 8
PDK1 38 10
PKB alpha 97 1
PKB beta 96 10
SGK1 102 2
S6K1 97 10
PKA 112 7
ROCK 2 112 7
PRK2 113 14
PKC alpha 91 11
PKC gamma 103 11
PKC zeta 106 13
PKD1 80 14
STK33 107 11
MSK1 104 8
MNK1 99 1
MNK2 123 41
MAPKAP-K2 101 14
MAPKAP-K3 109 7
PRAK 100 4
CAMKK beta 104 8
CAMK1 92 1
SmMLCK 97 14
PHK 117 19
DAPK1 113 4
CHK1 94 0
CHK2 106 7
GSK3 beta 96 16
CDK2-Cyclin A 91 6
PLK1 107 9
Aurora A 110 1
Aurora B 104 9
TLK1 103 18
LKB1 100 11
AMPK 99 7
MARK1 108 20
MARK2 102 10
MARK3 93 11
MARK4 143 3
BRSK1 102 13
BRSK2 90 4
MELK 110 9
NUAK1 107 7
TSSK1 103 6
CK1 delta 110 8
CK2 103 12
TTBK1 110 4
DYRK1A 97 8
DYRK2 101 5
DYRK3 109 2
NEK2a 97 8
NEK6 100 6
IKK beta 99 7
IKK epsilon 109 7
TBK1 132 13
PIM1 105 2
PIM2 105 5
PIM3 108 11
SRPK1 114 12
EF2K 103 18
EIF2AK3 104 2
HIPK1 100 3
HIPK2 96 9
HIPK3 108 4
CLK2 95 18
PAK2 109 2
PAK4 101 0
PAK5 92 7
PAK6 102 4
MST2 105 4
MST4 117 8
GCK 101 6
MINK1 100 1
MEKK1 114 7
MLK1 102 3
MLK3 97 3
TESK1 88 4
TAO1 126 1
ASK1 105 15
TAK1 103 5
IRAK1 118 2
IRAK4 109 22
RIPK2 105 9
OSR1 96 0
TTK 100 11
MPSK1 118 17
Src 100 3
Lck 101 7
CSK 98 6
YES1 105 12
ABL 105 4
BTK 108 1
JAK2 99 2
SYK 88 4
ZAP70 106 3
TIE2 100 10
BRK 129 10
EPH-A2 102 3
EPH-A4 113 19
EPH-B1 88 4
EPH-B2 115 21
EPH-B3 119 7
EPH-B4 85 18
FGF-R1 97 2
HER4 100 6
IGF-1R 105 3
IR 95 4
IRR 114 5
TrkA 98 5
VEGFR1 100 3

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