Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 0325901-Cl (CI-1055-Racemic mix of isomers) C16H14O4N2F2ClI 498.65 MEK1 WO2002006213 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 36 14
MKK2 55 9
MKK6 90 2
ERK1 100 7
ERK2 83 8
JNK1 87 1
JNK2 88 0
JNK3 83 16
p38 alpha MAPK 102 7
p38 beta MAPK 101 3
p38 gamma MAPK 80 3
p38 delta MAPK 84 3
ERK8 95 8
RSK1 122 7
RSK2 98 15
PDK1 100 2
PKB alpha 99 21
PKB beta 97 4
SGK1 71 4
S6K1 94 4
PKA 94 7
ROCK 2 102 1
PRK2 70 1
PKC alpha 93 12
PKC gamma 110 13
PKC zeta 89 2
PKD1 91 4
STK33 92 10
MSK1 98 0
MNK1 106 5
MNK2 89 7
MAPKAP-K2 104 12
MAPKAP-K3 94 3
PRAK 93 8
CAMKK beta 108 0
CAMK1 106 1
SmMLCK 102 23
PHK 94 2
DAPK1 97 6
CHK1 116 17
CHK2 104 2
GSK3 beta 89 9
CDK2-Cyclin A 95 7
PLK1 97 1
Aurora A 103 9
Aurora B 99 2
TLK1 95 10
LKB1 80 14
AMPK 111 18
MARK1 77 1
MARK2 101 10
MARK3 73 9
MARK4 119 12
BRSK1 98 11
BRSK2 108 9
MELK 109 11
NUAK1 108 14
CK1 delta 96 5
CK2 111 8
DYRK1A 91 3
DYRK2 107 13
DYRK3 107 0
NEK2a 98 4
NEK6 101 11
IKK beta 78 3
IKK epsilon 102 9
TBK1 111 5
PIM1 102 6
PIM2 91 13
PIM3 94 0
SRPK1 95 0
EF2K 84 7
EIF2AK3 103 25
HIPK1 96 5
HIPK2 102 7
HIPK3 90 2
CLK2 94 5
PAK2 95 3
PAK4 98 4
PAK5 102 13
PAK6 98 21
MST2 71 8
MST4 107 4
GCK 79 14
MINK1 119 10
MEKK1 88 5
MLK1 84 0
MLK3 83 18
TAO1 92 25
ASK1 102 13
TAK1 91 14
IRAK1 81 1
IRAK4 77 5
RIPK2 86 7
OSR1 87 22
TTK 105 3
MPSK1 87 10
Src 124 4
Lck 93 8
CSK 89 16
YES1 76 1
ABL 101 10
BTK 102 9
JAK2 5 1
SYK 73 46
ZAP70 77 14
TIE2 106 7
BRK 126 13
EPH-A2 112 11
EPH-A4 97 5
EPH-B1 107 6
EPH-B2 100 20
EPH-B3 113 17
EPH-B4 98 5
FGF-R1 110 28
HER4 86 4
IGF-1R 76 1
IR 93 28
IRR 84 0
TrkA 79 6
VEGFR1 98 8
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 3 1
MKK2 23 0
MKK6 67 6
ERK1 101 18
ERK2 79 6
JNK1 93 2
JNK2 92 8
JNK3 90 26
p38 alpha MAPK 97 0
p38 beta MAPK 133 18
p38 gamma MAPK 96 3
p38 delta MAPK 97 7
ERK8 98 19
RSK1 98 3
RSK2 89 3
PDK1 99 3
PKB alpha 99 4
PKB beta 90 13
SGK1 111 18
S6K1 80 17
PKA 103 3
ROCK 2 103 16
PRK2 79 13
PKC alpha 86 8
PKC gamma 100 0
PKC zeta 91 0
PKD1 87 8
STK33 90 4
MSK1 96 6
MNK1 95 15
MNK2 90 5
MAPKAP-K2 102 10
MAPKAP-K3 77 19
PRAK 100 13
CAMKK beta 103 1
CAMK1 84 2
SmMLCK 86 12
PHK 90 5
DAPK1 98 17
CHK1 119 2
CHK2 93 10
GSK3 beta 89 3
CDK2-Cyclin A 97 2
PLK1 93 1
Aurora A 104 12
Aurora B 78 0
TLK1 100 9
LKB1 77 3
AMPK 120 4
MARK1 71 4
MARK2 101 3
MARK3 88 5
MARK4 108 10
BRSK1 101 14
BRSK2 105 1
MELK 106 4
NUAK1 95 4
CK1 delta 97 2
CK2 98 13
DYRK1A 85 8
DYRK2 111 5
DYRK3 83 19
NEK2a 94 6
NEK6 103 15
IKK beta 89 9
IKK epsilon 103 11
TBK1 99 3
PIM1 71 8
PIM2 93 8
PIM3 65 5
SRPK1 86 7
EF2K 92 1
EIF2AK3 90 28
HIPK1 85 9
HIPK2 106 1
HIPK3 101 6
CLK2 91 4
PAK2 80 7
PAK4 77 14
PAK5 86 3
PAK6 103 2
MST2 75 16
MST4 94 3
GCK 91 1
MINK1 127 5
MEKK1 93 7
MLK1 85 10
MLK3 89 4
TAO1 99 25
ASK1 112 14
TAK1 92 6
IRAK1 79 2
IRAK4 91 11
RIPK2 84 8
OSR1 87 5
TTK 98 2
MPSK1 86 16
Src 72 1
Lck 104 11
CSK 88 13
YES1 79 1
ABL 107 11
BTK 97 9
JAK2 8 1
SYK 77 9
ZAP70 98 0
TIE2 87 5
BRK 110 8
EPH-A2 105 7
EPH-A4 100 4
EPH-B1 92 6
EPH-B2 77 2
EPH-B3 82 9
EPH-B4 86 3
FGF-R1 99 37
HER4 82 6
IGF-1R 98 8
IR 97 28
IRR 87 20
TrkA 78 14
VEGFR1 42 13

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