Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 0325901-Cl (CI-1055-R) C16H14O4N2F2ClI 498.65 MEK1 WO2002006213 Download

Results as Barchart

View results as a bar chart
10µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 18 5
MKK2 54 9
MKK6 93 6
ERK1 88 7
ERK2 90 6
JNK1 91 5
JNK2 90 9
JNK3 89 23
p38 alpha MAPK 96 6
p38 beta MAPK 99 12
p38 gamma MAPK 91 19
p38 delta MAPK 85 1
ERK8 104 16
RSK1 102 11
RSK2 104 14
PDK1 101 15
PKB alpha 107 16
PKB beta 95 7
SGK1 69 9
S6K1 97 18
PKA 87 16
ROCK 2 84 14
PRK2 82 2
PKC alpha 100 5
PKC gamma 91 4
PKC zeta 97 2
PKD1 89 23
STK33 87 32
MSK1 97 13
MNK1 103 14
MNK2 93 14
MAPKAP-K2 103 1
MAPKAP-K3 90 11
PRAK 98 7
CAMKK beta 92 3
CAMK1 96 5
SmMLCK 100 22
PHK 95 8
DAPK1 96 11
CHK1 130 1
CHK2 95 7
GSK3 beta 70 18
CDK2-Cyclin A 110 13
PLK1 81 1
Aurora A 112 9
Aurora B 87 8
TLK1 96 2
LKB1 113 13
AMPK 110 4
MARK1 85 14
MARK2 104 12
MARK3 91 9
MARK4 112 4
BRSK1 97 4
BRSK2 94 8
MELK 81 10
NUAK1 89 5
CK1 delta 89 6
CK2 107 13
DYRK1A 94 2
DYRK2 99 6
DYRK3 85 3
NEK2a 97 13
NEK6 95 1
IKK beta 88 2
IKK epsilon 103 4
TBK1 117 4
PIM1 92 7
PIM2 104 4
PIM3 78 10
SRPK1 80 7
EF2K 83 10
EIF2AK3 96 0
HIPK1 84 6
HIPK2 93 4
HIPK3 101 7
CLK2 103 14
PAK2 96 24
PAK4 97 22
PAK5 104 1
PAK6 95 0
MST2 83 12
MST4 103 4
GCK 90 7
MINK1 117 5
MEKK1 97 10
MLK1 95 2
MLK3 83 1
TAO1 101 8
ASK1 108 4
TAK1 77 7
IRAK1 84 5
IRAK4 81 4
RIPK2 99 1
OSR1 95 14
TTK 98 2
MPSK1 85 17
Src 104 5
Lck 92 7
CSK 93 5
YES1 82 1
ABL 103 19
BTK 110 19
JAK2 8 0
SYK 111 9
ZAP70 84 8
TIE2 97 20
BRK 115 4
EPH-A2 86 13
EPH-A4 86 5
EPH-B1 95 13
EPH-B2 64 10
EPH-B3 101 3
EPH-B4 90 5
FGF-R1 140 2
HER4 112 30
IGF-1R 88 12
IR 106 41
IRR 106 0
TrkA 72 6
VEGFR1 65 38
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 2 5
MKK2 16 3
MKK6 102 2
ERK1 106 12
ERK2 100 12
JNK1 117 9
JNK2 105 8
JNK3 85 1
p38 alpha MAPK 97 7
p38 beta MAPK 105 12
p38 gamma MAPK 98 3
p38 delta MAPK 97 19
ERK8 96 3
RSK1 102 4
RSK2 92 1
PDK1 109 6
PKB alpha 104 1
PKB beta 82 2
SGK1 74 9
S6K1 81 2
PKA 97 8
ROCK 2 120 53
PRK2 83 0
PKC alpha 108 3
PKC gamma 99 4
PKC zeta 104 12
PKD1 93 15
STK33 107 9
MSK1 96 4
MNK1 104 2
MNK2 110 5
MAPKAP-K2 102 3
MAPKAP-K3 89 2
PRAK 99 2
CAMKK beta 94 9
CAMK1 91 0
SmMLCK 98 14
PHK 90 6
DAPK1 90 8
CHK1 122 17
CHK2 114 11
GSK3 beta 88 12
CDK2-Cyclin A 109 2
PLK1 92 12
Aurora A 108 7
Aurora B 82 3
TLK1 104 10
LKB1 108 24
AMPK 107 2
MARK1 85 11
MARK2 103 5
MARK3 74 1
MARK4 127 4
BRSK1 112 9
BRSK2 96 5
MELK 97 8
NUAK1 107 6
CK1 delta 101 12
CK2 118 2
DYRK1A 104 11
DYRK2 107 4
DYRK3 85 9
NEK2a 102 5
NEK6 110 13
IKK beta 103 6
IKK epsilon 111 9
TBK1 101 1
PIM1 73 1
PIM2 97 19
PIM3 72 6
SRPK1 95 14
EF2K 93 13
EIF2AK3 105 8
HIPK1 92 18
HIPK2 104 1
HIPK3 107 13
CLK2 85 11
PAK2 91 9
PAK4 65 2
PAK5 85 4
PAK6 105 5
MST2 70 1
MST4 104 10
GCK 77 29
MINK1 144 16
MEKK1 105 3
MLK1 108 14
MLK3 92 7
TAO1 109 6
ASK1 116 2
TAK1 82 8
IRAK1 89 0
IRAK4 100 4
RIPK2 100 3
OSR1 93 4
TTK 121 9
MPSK1 101 1
Src 91 8
Lck 109 7
CSK 98 4
YES1 86 2
ABL 98 1
BTK 100 6
JAK2 9 1
SYK 74 20
ZAP70 100 14
TIE2 96 14
BRK 121 6
EPH-A2 94 8
EPH-A4 89 1
EPH-B1 115 10
EPH-B2 74 16
EPH-B3 113 7
EPH-B4 99 14
FGF-R1 83 14
HER4 87 8
IGF-1R 113 2
IR 107 24
IRR 112 33
TrkA 75 19
VEGFR1 39 10

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