Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PCI-32765 (Ibrutinib) C25H24N6O2 440.5 Btk Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080 Selleckchem Download

Results as Barchart

View results as a bar chart
10µM
1µM
0.1µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 85 2
MKK2 94 1
MKK6 82 0
ERK1 83 8
ERK2 94 7
JNK1 98 6
JNK2 89 9
JNK3 84 7
p38 alpha MAPK 99 1
p38 beta MAPK 94 20
p38 gamma MAPK 89 9
p38 delta MAPK 88 9
ERK8 85 3
RSK1 94 12
RSK2 103 6
PDK1 93 8
PKB alpha 79 10
PKB beta 80 4
SGK1 95 7
S6K1 93 4
PKA 89 1
ROCK 2 93 3
PRK2 109 9
PKC alpha 99 8
PKC gamma 85 0
PKC zeta 90 10
PKD1 64 16
STK33 97 2
MSK1 94 6
MNK1 91 17
MNK2 106 9
MAPKAP-K2 88 5
MAPKAP-K3 109 5
PRAK 101 8
CAMKK beta 86 5
CAMK1 80 13
SmMLCK 79 1
PHK 116 34
DAPK1 95 4
CHK1 76 9
CHK2 92 8
GSK3 beta 104 17
CDK2-Cyclin A 89 5
PLK1 88 13
Aurora A 92 0
Aurora B 96 13
TLK1 96 12
LKB1 106 5
AMPK 88 4
MARK1 101 14
MARK2 88 11
MARK3 98 11
MARK4 111 1
BRSK1 81 23
BRSK2 100 9
MELK 69 5
NUAK1 99 10
TSSK1 105 2
CK1 delta 98 5
CK2 104 15
TTBK1 78 5
DYRK1A 112 8
DYRK2 83 1
DYRK3 93 8
NEK2a 93 6
NEK6 76 11
IKK beta 94 4
IKK epsilon 100 4
TBK1 102 3
PIM1 98 2
PIM2 99 1
PIM3 94 4
SRPK1 100 9
EF2K 88 0
EIF2AK3 110 13
HIPK1 75 4
HIPK2 91 11
HIPK3 100 12
CLK2 96 15
PAK2 87 1
PAK4 93 10
PAK5 93 13
PAK6 95 3
MST2 88 3
MST4 100 10
GCK 98 5
MINK1 90 0
MEKK1 106 6
MLK1 104 7
MLK3 87 0
TESK1 69 9
TAO1 113 5
ASK1 103 1
TAK1 102 10
IRAK1 108 7
IRAK4 103 12
RIPK2 21 1
OSR1 96 1
TTK 95 1
MPSK1 99 2
Src 37 4
Lck 22 1
CSK 25 6
YES1 20 0
ABL 87 13
BTK 55 3
JAK2 90 2
SYK 90 7
ZAP70 93 16
TIE2 71 10
BRK 10 3
EPH-A2 91 10
EPH-A4 97 20
EPH-B1 72 4
EPH-B2 102 10
EPH-B3 99 3
EPH-B4 83 9
FGF-R1 52 8
HER4 7 0
IGF-1R 95 0
IR 77 3
IRR 94 3
TrkA 64 9
VEGFR1 40 3
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 76 3
MKK2 94 6
MKK6 97 1
ERK1 93 21
ERK2 99 0
JNK1 98 7
JNK2 101 3
JNK3 96 5
p38 alpha MAPK 103 3
p38 beta MAPK 103 8
p38 gamma MAPK 112 1
p38 delta MAPK 104 14
ERK8 98 6
RSK1 101 6
RSK2 106 19
PDK1 124 14
PKB alpha 97 1
PKB beta 93 7
SGK1 107 0
S6K1 86 8
PKA 101 0
ROCK 2 111 3
PRK2 100 9
PKC alpha 106 21
PKC gamma 104 14
PKC zeta 98 1
PKD1 69 7
STK33 84 10
MSK1 101 6
MNK1 115 14
MNK2 82 21
MAPKAP-K2 95 9
MAPKAP-K3 109 0
PRAK 107 6
CAMKK beta 109 5
CAMK1 99 12
SmMLCK 90 1
PHK 104 10
DAPK1 95 15
CHK1 93 9
CHK2 77 6
GSK3 beta 95 6
CDK2-Cyclin A 99 10
PLK1 95 3
Aurora A 57 2
Aurora B 61 7
TLK1 99 2
LKB1 134 43
AMPK 101 7
MARK1 103 12
MARK2 102 6
MARK3 94 3
MARK4 114 5
BRSK1 80 28
BRSK2 91 2
MELK 105 37
NUAK1 82 8
TSSK1 108 4
CK1 delta 111 8
CK2 115 7
TTBK1 100 9
DYRK1A 105 8
DYRK2 105 9
DYRK3 86 14
NEK2a 107 12
NEK6 99 9
IKK beta 107 6
IKK epsilon 95 19
TBK1 113 4
PIM1 95 1
PIM2 100 17
PIM3 96 12
SRPK1 115 8
EF2K 102 21
EIF2AK3 81 5
HIPK1 87 2
HIPK2 91 14
HIPK3 123 4
CLK2 95 9
PAK2 72 4
PAK4 85 9
PAK5 97 2
PAK6 97 3
MST2 65 2
MST4 73 4
GCK 77 6
MINK1 91 4
MEKK1 103 17
MLK1 89 5
MLK3 65 5
TESK1 71 14
TAO1 119 1
ASK1 128 1
TAK1 106 13
IRAK1 115 3
IRAK4 102 9
RIPK2 5 0
OSR1 96 4
TTK 101 3
MPSK1 117 9
Src 13 1
Lck 14 2
CSK 15 13
YES1 16 0
ABL 80 1
BTK 55 1
JAK2 103 2
SYK 100 4
ZAP70 107 5
TIE2 34 4
BRK 4 1
EPH-A2 98 9
EPH-A4 92 13
EPH-B1 90 9
EPH-B2 65 0
EPH-B3 96 5
EPH-B4 74 0
FGF-R1 24 1
HER4 8 1
IGF-1R 93 1
IR 99 10
IRR 101 0
TrkA 46 1
VEGFR1 7 1
Screening Concentration: 10µM
Kinase % Activity Remaining Standard Deviation
MKK1 56 3
MKK2 63 2
MKK6 61 12
ERK1 84 7
ERK2 90 12
JNK1 75 1
JNK2 123 29
JNK3 86 2
p38 alpha MAPK 101 8
p38 beta MAPK 68 4
p38 gamma MAPK 88 10
p38 delta MAPK 80 3
ERK8 74 1
RSK1 46 5
RSK2 68 7
PDK1 102 14
PKB alpha 78 1
PKB beta 71 4
SGK1 84 1
S6K1 66 1
PKA 97 11
ROCK 2 69 6
PRK2 90 2
PKC alpha 100 12
PKC gamma 99 5
PKC zeta 81 3
PKD1 30 6
STK33 113 101
MSK1 55 6
MNK1 84 6
MNK2 67 4
MAPKAP-K2 90 1
MAPKAP-K3 75 20
PRAK 83 11
CAMKK beta 80 3
CAMK1 33 8
SmMLCK 44 6
PHK 92 7
DAPK1 84 5
CHK1 77 0
CHK2 35 9
GSK3 beta 75 9
CDK2-Cyclin A 84 6
PLK1 76 3
Aurora A 10 1
Aurora B 13 1
TLK1 96 6
LKB1 100 0
AMPK 78 1
MARK1 88 11
MARK2 82 7
MARK3 76 14
MARK4 80 6
BRSK1 49 11
BRSK2 61 12
MELK 56 18
NUAK1 26 13
TSSK1 68 5
CK1 delta 115 15
CK2 111 10
TTBK1 81 11
DYRK1A 87 1
DYRK2 79 2
DYRK3 68 5
NEK2a 35 2
NEK6 93 12
IKK beta 90 12
IKK epsilon 66 15
TBK1 90 7
PIM1 81 3
PIM2 97 15
PIM3 88 4
SRPK1 99 0
EF2K 90 6
EIF2AK3 28 2
HIPK1 75 14
HIPK2 66 2
HIPK3 110 8
CLK2 71 10
PAK2 55 4
PAK4 42 6
PAK5 50 3
PAK6 82 3
MST2 41 9
MST4 27 6
GCK 38 0
MINK1 57 3
MEKK1 56 4
MLK1 27 18
MLK3 28 5
TESK1 38 8
TAO1 84 1
ASK1 111 6
TAK1 66 4
IRAK1 98 32
IRAK4 86 3
RIPK2 2 0
OSR1 82 9
TTK 82 9
MPSK1 104 7
Src 6 4
Lck 9 3
CSK 3 0
YES1 13 0
ABL 39 2
BTK 42 4
JAK2 83 13
SYK 52 6
ZAP70 101 10
TIE2 9 1
BRK 8 5
EPH-A2 64 5
EPH-A4 45 1
EPH-B1 86 2
EPH-B2 11 1
EPH-B3 51 2
EPH-B4 39 0
FGF-R1 15 2
HER4 5 1
IGF-1R 63 19
IR 31 11
IRR 29 5
TrkA 13 7
VEGFR1 2 1

Do you need any help? Please get in touch and we’ll be happy to lend a hand.