Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
MSC 2032964A C16H13F3N6O 362.31 ASK1 Guo X. (2010) EMBO Molecular Medicine 2 504-515 Download

Results as Barchart

View results as a bar chart
1µM
0.1µM
0.01µM

Results as Table

Screening Concentration: 0.1µM
Kinase % Activity Remaining Standard Deviation
MKK1 76 3
MKK2 90 16
MKK6 110 1
ERK1 127 18
ERK2 96 3
JNK1 93 1
JNK2 84 11
JNK3 88 1
p38 alpha MAPK 121 18
p38 beta MAPK 121 4
p38 gamma MAPK 102 12
p38 delta MAPK 90 5
ERK8 110 17
RSK1 102 4
RSK2 106 0
PDK1 91 10
PKB alpha 95 17
PKB beta 103 5
SGK1 146 55
S6K1 104 12
PKA 99 1
ROCK 2 106 14
PRK2 104 4
PKC alpha 89 9
PKC gamma 115 2
PKC zeta 111 30
PKD1 103 12
STK33 106 12
MSK1 114 1
MNK1 99 8
MNK2 139 23
MAPKAP-K2 102 9
MAPKAP-K3 114 11
PRAK 112 4
CAMKK beta 96 4
CAMK1 128 7
SmMLCK 93 5
PHK 115 0
DAPK1 95 10
CHK1 99 2
CHK2 114 16
GSK3 beta 92 4
CDK2-Cyclin A 98 5
PLK1 128 12
Aurora A 128 3
Aurora B 103 15
TLK1 99 4
LKB1 132 8
AMPK 93 1
MARK1 90 4
MARK2 209 146
MARK3 87 17
MARK4 111 6
BRSK1 90 10
BRSK2 116 2
MELK 107 13
NUAK1 116 6
CK1 delta 93 7
CK2 127 16
DYRK1A 92 7
DYRK2 92 4
DYRK3 119 15
NEK2a 97 10
NEK6 113 12
IKK beta 217 95
IKK epsilon 106 15
TBK1 101 5
PIM1 96 6
PIM2 109 15
PIM3 101 3
SRPK1 90 9
EF2K 118 16
EIF2AK3 117 10
HIPK1 96 14
HIPK2 116 1
HIPK3 102 16
CLK2 82 12
PAK2 126 3
PAK4 98 2
PAK5 114 2
PAK6 88 9
MST2 116 3
MST4 99 2
GCK 103 11
MINK1 113 18
MEKK1 108 7
MLK1 80 1
MLK3 104 7
TAO1 101 0
ASK1 54 7
TAK1 105 20
IRAK1 100 13
IRAK4 90 6
RIPK2 87 2
OSR1 114 5
TTK 99 14
MPSK1 96 15
Src 107 6
Lck 97 0
CSK 95 2
YES1 87 2
ABL 108 21
BTK 103 12
JAK2 100 16
SYK 99 11
ZAP70 77 16
TIE2 103 5
BRK 130 4
EPH-A2 93 6
EPH-A4 124 11
EPH-B1 120 10
EPH-B2 108 4
EPH-B3 95 7
EPH-B4 104 5
FGF-R1 105 9
HER4 88 9
IGF-1R 89 14
IR 115 30
IRR 104 9
TrkA 83 6
VEGFR1 88 2
Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 61 17
MKK2 69 4
MKK6 85 16
ERK1 116 1
ERK2 102 7
JNK1 91 11
JNK2 90 10
JNK3 79 12
p38 alpha MAPK 114 1
p38 beta MAPK 107 9
p38 gamma MAPK 80 3
p38 delta MAPK 90 8
ERK8 102 5
RSK1 65 8
RSK2 89 7
PDK1 92 10
PKB alpha 104 7
PKB beta 94 4
SGK1 100 11
S6K1 103 9
PKA 88 6
ROCK 2 97 5
PRK2 75 8
PKC alpha 94 11
PKC gamma 106 6
PKC zeta 84 6
PKD1 86 14
STK33 88 7
MSK1 95 6
MNK1 98 13
MNK2 91 2
MAPKAP-K2 99 7
MAPKAP-K3 97 3
PRAK 98 10
CAMKK beta 105 13
CAMK1 109 11
SmMLCK 106 11
PHK 92 3
DAPK1 95 3
CHK1 104 1
CHK2 89 10
GSK3 beta 79 6
CDK2-Cyclin A 85 5
PLK1 103 2
Aurora A 96 0
Aurora B 89 1
TLK1 90 6
LKB1 105 18
AMPK 108 6
MARK1 86 6
MARK2 94 21
MARK3 86 11
MARK4 119 4
BRSK1 95 3
BRSK2 109 1
MELK 92 9
NUAK1 98 8
CK1 delta 59 2
CK2 102 4
DYRK1A 81 9
DYRK2 90 5
DYRK3 91 6
NEK2a 96 1
NEK6 101 2
IKK beta 82 29
IKK epsilon 96 7
TBK1 102 3
PIM1 98 9
PIM2 108 0
PIM3 95 11
SRPK1 102 8
EF2K 84 3
EIF2AK3 104 9
HIPK1 92 8
HIPK2 105 4
HIPK3 96 13
CLK2 40 4
PAK2 104 6
PAK4 102 1
PAK5 91 9
PAK6 93 10
MST2 93 1
MST4 106 2
GCK 108 3
MINK1 120 1
MEKK1 91 4
MLK1 75 2
MLK3 87 8
TAO1 105 7
ASK1 11 0
TAK1 84 2
IRAK1 89 3
IRAK4 83 4
RIPK2 89 3
OSR1 92 7
TTK 96 13
MPSK1 83 6
Src 102 5
Lck 95 8
CSK 89 5
YES1 74 19
ABL 97 6
BTK 101 9
JAK2 100 1
SYK 104 32
ZAP70 84 14
TIE2 69 1
BRK 124 8
EPH-A2 100 9
EPH-A4 93 10
EPH-B1 94 1
EPH-B2 95 7
EPH-B3 99 7
EPH-B4 96 7
FGF-R1 101 17
HER4 88 3
IGF-1R 79 11
IR 100 13
IRR 94 5
TrkA 81 5
VEGFR1 108 8
Screening Concentration: 0.01µM
Kinase % Activity Remaining Standard Deviation
MKK1 72 11
MKK2 90 12
MKK6 100 18
ERK1 120 13
ERK2 92 5
JNK1 87 11
JNK2 89 3
JNK3 85 14
p38 alpha MAPK 109 10
p38 beta MAPK 106 4
p38 gamma MAPK 71 0
p38 delta MAPK 102 1
ERK8 102 2
RSK1 99 12
RSK2 112 2
PDK1 99 4
PKB alpha 97 9
PKB beta 97 8
SGK1 103 1
S6K1 125 1
PKA 98 4
ROCK 2 105 1
PRK2 77 11
PKC alpha 87 5
PKC gamma 101 3
PKC zeta 96 3
PKD1 91 7
STK33 97 2
MSK1 114 4
MNK1 94 10
MNK2 95 9
MAPKAP-K2 99 6
MAPKAP-K3 97 9
PRAK 97 15
CAMKK beta 108 4
CAMK1 116 6
SmMLCK 96 5
PHK 104 11
DAPK1 112 6
CHK1 103 3
CHK2 93 8
GSK3 beta 87 17
CDK2-Cyclin A 95 0
PLK1 104 8
Aurora A 108 13
Aurora B 93 11
TLK1 107 9
LKB1 107 1
AMPK 108 8
MARK1 93 1
MARK2 90 30
MARK3 83 12
MARK4 127 4
BRSK1 102 16
BRSK2 116 9
MELK 97 4
NUAK1 100 5
CK1 delta 92 4
CK2 99 14
DYRK1A 94 5
DYRK2 104 11
DYRK3 92 5
NEK2a 97 12
NEK6 114 3
IKK beta 79 12
IKK epsilon 114 16
TBK1 99 0
PIM1 104 17
PIM2 106 3
PIM3 104 1
SRPK1 100 10
EF2K 99 0
EIF2AK3 109 15
HIPK1 96 15
HIPK2 100 4
HIPK3 101 9
CLK2 101 9
PAK2 110 7
PAK4 111 18
PAK5 97 6
PAK6 100 3
MST2 99 4
MST4 106 1
GCK 112 6
MINK1 125 2
MEKK1 97 8
MLK1 90 3
MLK3 88 3
TAO1 91 9
ASK1 98 9
TAK1 92 7
IRAK1 94 4
IRAK4 90 15
RIPK2 89 3
OSR1 83 11
TTK 93 9
MPSK1 82 7
Src 100 7
Lck 106 2
CSK 96 2
YES1 81 5
ABL 95 6
BTK 108 4
JAK2 114 8
SYK 107 15
ZAP70 76 19
TIE2 94 8
BRK 114 11
EPH-A2 95 0
EPH-A4 101 3
EPH-B1 106 2
EPH-B2 124 26
EPH-B3 99 14
EPH-B4 106 5
FGF-R1 111 6
HER4 106 2
IGF-1R 88 4
IR 107 11
IRR 91 8
TrkA 80 11
VEGFR1 109 7

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