Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
PD 0325901 C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315. Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504. WO2002006213 Axon Download

Results as Barchart

View results as a bar chart
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remaining Standard Deviation
MKK1 8 0
MKK2 20 9
MKK6 104 3
ERK1 110 1
ERK2 102 9
ERK5 116 11
JNK1 108 9
JNK2 100 3
JNK3 98 7
p38 alpha MAPK 102 6
p38 beta MAPK 110 0
p38 gamma MAPK 114 12
p38 delta MAPK 105 22
ERK8 104 10
RSK1 123 5
RSK2 106 4
PDK1 119 7
PKB alpha 101 5
PKB beta 108 2
SGK1 106 6
S6K1 121 16
PKA 104 4
ROCK 2 96 8
PRK2 111 4
PKC alpha 130 10
PKC gamma 109 15
PKC zeta 107 9
PKD1 117 3
STK33 109 8
MSK1 105 1
MNK1 98 5
MNK2 104 13
MAPKAP-K2 107 18
MAPKAP-K3 124 1
PRAK 97 6
CAMKK beta 123 3
CAMK1 113 3
SmMLCK 94 1
PHK 127 9
DAPK1 107 5
CHK1 79 6
CHK2 125 8
GSK3 beta 125 10
CDK2-Cyclin A 88 3
CDK9-Cyclin T1 108 6
PLK1 119 7
Aurora A 106 8
Aurora B 109 1
TLK1 97 3
LKB1 111 9
AMPK (hum) 104 5
MARK1 115 4
MARK2 111 9
MARK3 115 4
MARK4 110 8
BRSK1 107 3
BRSK2 87 15
MELK 95 14
NUAK1 87 10
SIK2 128 1
SIK3 108 4
TSSK1 100 9
CK1 gamma 2 114 11
CK1 delta 113 30
CK2 120 1
TTBK1 114 18
TTBK2 108 26
DYRK1A 111 2
DYRK2 124 10
DYRK3 105 18
NEK2a 108 5
NEK6 111 1
IKK beta 121 10
IKK epsilon 104 5
TBK1 97 8
PIM1 117 1
PIM2 127 2
PIM3 110 16
SRPK1 108 0
EF2K 129 12
EIF2AK3 114 7
HIPK1 107 5
HIPK2 100 5
HIPK3 100 5
CLK2 109 18
PAK2 105 2
PAK4 111 1
PAK5 88 15
PAK6 103 8
MST2 127 13
MST3 121 10
MST4 108 2
GCK 109 5
MAP4K3 109 0
MAP4K5 104 2
MINK1 98 11
MEKK1 101 17
MLK1 109 5
MLK3 114 10
TESK1 124 26
TAO1 96 11
ASK1 93 11
TAK1 101 10
IRAK1 103 1
IRAK4 110 20
RIPK2 117 1
OSR1 119 4
TTK 99 8
MPSK1 111 8
WNK1 102 2
ULK1 108 1
ULK2 100 11
TGFBR1 118 6
Src 118 9
Lck 95 7
CSK 80 12
YES1 103 1
ABL 100 8
BTK 111 18
JAK2 120 10
SYK 107 23
ZAP70 113 5
TIE2 105 21
BRK 105 2
EPH-A2 102 4
EPH-A4 106 7
EPH-B1 98 5
EPH-B2 114 0
EPH-B3 107 8
EPH-B4 108 1
FGF-R1 119 11
HER4 118 21
IGF-1R 126 8
IR 106 9
IRR 97 7
TrkA 97 13
DDR2 117 6
VEGFR1 111 7
PDGFRA 114 24
PINK 106 9

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