Kinase Profiling Inhibitor Database

Inhibitor Structure Image Brutto MW Action Reference Reference 2 Patent Commercial Vendor Notes Results
CP-690550 (Tasocitinib) C16H20N6O 312.38 JAK Manshouri T. (2008) Cancer Sci. 99(6) 1265-73 Selleck Download

Results as Barchart

View results as a bar chart
0.1µM
1µM

Results as Table

Screening Concentration: 1µM
Kinase % Activity Remainingsort ascending Standard Deviation
SYK 152 16
DAPK1 145 5
CAMKK beta 139 15
EPH-B4 131 46
p38 gamma MAPK 130 9
HIPK2 128 21
IKK beta 126 3
PKB alpha 125 4
ZAP70 125 3
PDK1 123 3
PRAK 123 7
PIM2 121 21
PLK1 121 18
ERK8 121 1
EPH-A4 121 2
MAPKAP-K3 118 7
PAK4 116 16
PAK6 116 10
HER4 116 8
TTK 115 7
p38 beta MAPK 115 3
MNK1 115 0
PIM3 114 9
EIF2AK3 114 8
PAK2 114 2
TAK1 113 34
MKK2 112 20
IRAK1 111 4
GSK3 beta 110 2
DYRK3 110 18
MST4 109 0
IGF-1R 109 9
HIPK3 109 14
ERK1 108 5
p38 delta MAPK 108 17
NEK2a 107 32
JNK3 107 10
SGK1 106 19
PKC gamma 106 20
CHK2 106 7
PKD1 106 27
TIE2 106 19
CLK2 106 10
EPH-A2 106 6
CK1 delta 105 4
ASK1 105 7
TLK1 104 8
SmMLCK 104 3
EPH-B3 103 8
ABL 103 13
EF2K 103 1
p38 alpha MAPK 103 4
TAO1 103 4
STK33 103 19
IRR 102 3
PKC zeta 102 5
DYRK1A 102 1
PIM1 101 8
ERK2 99 17
DYRK2 99 14
BTK 96 6
LKB1 95 5
OSR1 94 12
PAK5 94 4
EPH-B1 93 4
CAMK1 93 1
Aurora A 93 8
PKB beta 92 6
CK2 92 1
RIPK2 92 3
MAPKAP-K2 91 11
EPH-B2 91 10
NEK6 90 5
IKK epsilon 90 7
Src 90 7
MINK1 90 9
MLK1 90 8
HIPK1 90 4
MKK6 89 2
PKA 89 1
SRPK1 89 8
JNK2 88 9
GCK 87 0
IR 87 8
TrkA 87 11
RSK2 86 2
MARK4 86 1
CHK1 86 13
MARK2 85 4
PHK 85 11
CSK 84 7
AMPK 83 1
MPSK1 83 14
TBK1 83 19
MEKK1 83 80
BRSK2 82 5
JNK1 81 5
BRK 80 18
IRAK4 80 1
S6K1 77 16
MSK1 76 15
RSK1 76 23
MLK3 75 1
MELK 74 5
BRSK1 73 2
PKC alpha 71 0
CDK2-Cyclin A 69 4
Aurora B 69 6
MKK1 67 6
YES1 65 4
MNK2 64 10
MST2 64 12
MARK1 63 1
VEGFR1 58 10
ROCK 2 46 9
FGF-R1 42 4
MARK3 33 4
Lck 30 0
NUAK1 30 2
PRK2 22 0
JAK2 3 1
Screening Concentration: 0.1µM
Kinase % Activity Remainingsort ascending Standard Deviation
ZAP70 133 0
SYK 131 7
ASK1 130 11
PLK1 128 7
PIM3 124 12
DAPK1 123 11
ERK8 121 6
EPH-B2 121 12
HER4 121 19
EPH-B4 120 4
JNK3 119 12
Aurora A 119 16
HIPK2 117 6
CDK2-Cyclin A 116 37
DYRK3 116 2
CAMKK beta 116 10
ABL 116 10
MELK 115 12
p38 gamma MAPK 115 6
TAK1 115 7
PKB alpha 115 1
EPH-A2 114 19
PRAK 113 10
HIPK1 112 4
OSR1 112 9
PIM1 112 5
CAMK1 111 2
MKK2 110 3
CK1 delta 109 9
EPH-A4 109 3
GCK 109 7
GSK3 beta 108 9
HIPK3 108 3
CLK2 108 1
PDK1 107 14
TrkA 106 13
p38 beta MAPK 106 12
IRAK1 106 3
MKK1 105 6
IKK beta 105 2
SmMLCK 105 3
IR 105 9
TAO1 104 12
PAK4 104 10
YES1 104 3
IGF-1R 104 11
DYRK2 103 5
IRR 103 5
NEK2a 102 16
PIM2 102 5
p38 delta MAPK 101 7
LKB1 101 9
BRSK2 101 3
EF2K 100 2
p38 alpha MAPK 100 1
PKC gamma 100 21
MNK1 100 11
TLK1 100 3
PAK6 100 3
VEGFR1 99 5
PKC zeta 99 11
TIE2 99 1
PAK2 99 2
TTK 99 3
TBK1 99 6
STK33 98 4
MARK2 98 1
EIF2AK3 97 9
CK2 97 7
MNK2 97 2
MKK6 97 8
ERK1 97 4
ERK2 97 10
MEKK1 97 7
PKC alpha 96 0
RSK1 96 6
MINK1 96 7
PHK 96 2
CHK2 95 9
AMPK 95 5
ROCK 2 95 15
MPSK1 94 10
MARK3 94 16
PKA 94 4
JNK2 94 4
BTK 94 11
EPH-B1 93 4
MARK4 93 2
PKD1 92 4
DYRK1A 92 7
BRK 92 7
Aurora B 92 8
Src 92 5
SGK1 92 2
BRSK1 92 7
RIPK2 91 9
RSK2 91 3
MAPKAP-K3 91 4
CHK1 88 1
S6K1 88 0
IRAK4 87 0
NEK6 87 3
IKK epsilon 87 8
MST4 87 8
PAK5 86 7
MLK1 86 5
EPH-B3 85 5
PKB beta 85 9
FGF-R1 85 3
SRPK1 84 6
MLK3 83 12
MSK1 83 10
MAPKAP-K2 82 7
MARK1 82 10
JNK1 80 3
MST2 79 7
CSK 78 3
NUAK1 74 5
Lck 73 9
PRK2 50 2
JAK2 4 0

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